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Genetically-defined metabolic reprogramming in cancer
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PubMed
title
Genetically-defined metabolic reprogramming in cancer
(English)
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author
Ralph J DeBerardinis
series ordinal
2
object named as
Ralph J. DeBerardinis
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Crossref
author name string
Andrew R. Mullen
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1
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Crossref
language of work or name
English
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PubMed
publication date
November 2012
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PubMed
published in
Trends in Endocrinology and Metabolism
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PubMed
volume
23
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stated in
PubMed
issue
11
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stated in
PubMed
page(s)
552-9
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stated in
PubMed
cites work
Hallmarks of Cancer: The Next Generation
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Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of α-ketoglutarate-dependent dioxygenases
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PubMed Central
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The common feature of leukemia-associated IDH1 and IDH2 mutations is a neomorphic enzyme activity converting alpha-ketoglutarate to 2-hydroxyglutarate
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21 March 2017
Cancer-associated IDH1 mutations produce 2-hydroxyglutarate
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PubMed Central
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21 March 2017
Recurring mutations found by sequencing an acute myeloid leukemia genome
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PubMed Central
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21 March 2017
SDH5, a gene required for flavination of succinate dehydrogenase, is mutated in paraganglioma
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PubMed Central
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21 March 2017
Understanding the Warburg effect: the metabolic requirements of cell proliferation
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21 March 2017
IDH1 and IDH2 mutations in gliomas
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21 March 2017
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21 March 2017
Brick by brick: metabolism and tumor cell growth
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21 March 2017
DNA damage signaling and p53-dependent senescence after prolonged beta-interferon stimulation
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PubMed Central
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21 March 2017
The Hallmarks of Cancer
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21 March 2017
Mutation of the fumarase gene in two siblings with progressive encephalopathy and fumarase deficiency
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21 March 2017
The oncometabolite 2-hydroxyglutarate inhibits histone lysine demethylases
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PubMed Central
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21 March 2017
Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis
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21 March 2017
Regulation of cancer cell metabolism
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PubMed Central
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21 March 2017
IDH2 mutations in patients with D-2-hydroxyglutaric aciduria
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PubMed Central
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21 March 2017
Neuronal apoptosis linked to EglN3 prolyl hydroxylase and familial pheochromocytoma genes: developmental culling and cancer
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21 March 2017
Succinate links TCA cycle dysfunction to oncogenesis by inhibiting HIF-alpha prolyl hydroxylase
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21 March 2017
Gene mutations in the succinate dehydrogenase subunit SDHB cause susceptibility to familial pheochromocytoma and to familial paraganglioma
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PubMed Central
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21 March 2017
A functional screen for Myc-responsive genes reveals serine hydroxymethyltransferase, a major source of the one-carbon unit for cell metabolism
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21 March 2017
IDH mutation impairs histone demethylation and results in a block to cell differentiation
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3466334
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7 April 2017
IDH1 mutation is sufficient to establish the glioma hypermethylator phenotype
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PubMed Central
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7 April 2017
Reductive glutamine metabolism by IDH1 mediates lipogenesis under hypoxia
1 reference
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PubMed Central
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7 April 2017
Otto Warburg's contributions to current concepts of cancer metabolism
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7 April 2017
Leukemic IDH1 and IDH2 mutations result in a hypermethylation phenotype, disrupt TET2 function, and impair hematopoietic differentiation
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PubMed Central
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7 April 2017
Mutation in TET2 in myeloid cancers
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PubMed Central
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7 April 2017
HIF overexpression correlates with biallelic loss of fumarate hydratase in renal cancer: novel role of fumarate in regulation of HIF stability
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7 April 2017
Mutations in SDHD, a mitochondrial complex II gene, in hereditary paraganglioma
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3466334
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7 April 2017
Cancer-associated isocitrate dehydrogenase mutations inactivate NADPH-dependent reductive carboxylation
1 reference
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PubMed Central
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28 September 2017
Cellular metabolism and disease: what do metabolic outliers teach us?
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28 September 2017
Progress in understanding 2-hydroxyglutaric acidurias
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3466334
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28 September 2017
Transformation by the (R)-enantiomer of 2-hydroxyglutarate linked to EGLN activation.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3466334
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28 September 2017
2-hydroxyglutarate detection by magnetic resonance spectroscopy in IDH-mutated patients with gliomas
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3466334
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28 September 2017
Magnetic resonance of 2-hydroxyglutarate in IDH1-mutated low-grade gliomas
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3466334
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28 September 2017
Detection of 2-hydroxyglutarate in IDH-mutated glioma patients by in vivo spectral-editing and 2D correlation magnetic resonance spectroscopy
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3466334
retrieved
28 September 2017
Hypoxia promotes isocitrate dehydrogenase-dependent carboxylation of α-ketoglutarate to citrate to support cell growth and viability
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3466334
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28 September 2017
Reductive carboxylation supports growth in tumour cells with defective mitochondria.
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3466334
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28 September 2017
Non-invasive detection of 2-hydroxyglutarate and other metabolites in IDH1 mutant glioma patients using magnetic resonance spectroscopy
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3466334
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28 September 2017
Renal cyst formation in Fh1-deficient mice is independent of the Hif/Phd pathway: roles for fumarate in KEAP1 succination and Nrf2 signaling
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3466334
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28 September 2017
An antioxidant response phenotype shared between hereditary and sporadic type 2 papillary renal cell carcinoma
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PubMed Central
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28 September 2017
Comparative metabolic flux profiling of melanoma cell lines: beyond the Warburg effect
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28 September 2017
Genomic imprinting at a boundary element flanking the SDHD locus
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PubMed Central
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28 September 2017
Haem oxygenase is synthetically lethal with the tumour suppressor fumarate hydratase
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PubMed Central
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28 September 2017
Phosphoglycerate dehydrogenase diverts glycolytic flux and contributes to oncogenesis
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PubMed Central
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28 September 2017
Revisiting the TCA cycle: signaling to tumor formation
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PubMed Central
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28 September 2017
Functional genomics reveal that the serine synthesis pathway is essential in breast cancer
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3466334
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28 September 2017
Aberrant succination of proteins in fumarate hydratase-deficient mice and HLRCC patients is a robust biomarker of mutation status
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3466334
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28 September 2017
IDH1 and IDH2 mutations are frequent events in central chondrosarcoma and central and periosteal chondromas but not in other mesenchymal tumours
1 reference
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PubMed Central
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28 September 2017
Nucleotide deficiency promotes genomic instability in early stages of cancer development
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PubMed Central
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28 September 2017
Metabolic regulation by p53.
1 reference
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PubMed Central
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28 September 2017
Glutamine: pleiotropic roles in tumor growth and stress resistance
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3466334
retrieved
28 September 2017
Profiling the effects of isocitrate dehydrogenase 1 and 2 mutations on the cellular metabolome
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3466334
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28 September 2017
Enhanced serine production by bone metastatic breast cancer cells stimulates osteoclastogenesis
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PubMed Central
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28 September 2017
Q's next: the diverse functions of glutamine in metabolism, cell biology and cancer
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3466334
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28 September 2017
Inhibition of succinate dehydrogenase dysregulates histone modification in mammalian cells
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3466334
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28 September 2017
Glioblastoma cells require glutamate dehydrogenase to survive impairments of glucose metabolism or Akt signaling
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3466334
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28 September 2017
Is cancer a disease of abnormal cellular metabolism? New angles on an old idea
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PubMed Central
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28 September 2017
The kinesin KIF1Bbeta acts downstream from EglN3 to induce apoptosis and is a potential 1p36 tumor suppressor
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3466334
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28 September 2017
D-2-Hydroxyglutaric aciduria: unravelling the biochemical pathway and the genetic defect
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3466334
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28 September 2017
Novel mutations in FH and expansion of the spectrum of phenotypes expressed in families with hereditary leiomyomatosis and renal cell cancer
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28 September 2017
Germline mutations in FH predispose to dominantly inherited uterine fibroids, skin leiomyomata and papillary renal cell cancer
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PubMed Central
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28 September 2017
Metabolic enzymes as oncogenes or tumor suppressors
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31 May 2018
Somatic mutations of the KEAP1 gene in common solid cancers.
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3466334
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28 November 2018
Maternal transmission of symptomatic disease with SDHD mutation: fact or fiction?
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28 November 2018
Mutations in SDHC cause autosomal dominant paraganglioma, type 3.
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3466334
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28 November 2018
S-(2-Succinyl)cysteine: a novel chemical modification of tissue proteins by a Krebs cycle intermediate
1 reference
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PubMed
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https://pubmed.ncbi.nlm.nih.gov/22858391
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Somatic mutations of IDH1 and IDH2 in the leukemic transformation of myeloproliferative neoplasms
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/22858391
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12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Identifiers
DOI
10.1016/J.TEM.2012.06.009
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
4879676
OpenCitations bibliographic resource ID
4879676
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
4879676
PMC publication ID
3466334
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
4879676
PubMed publication ID
22858391
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
4879676
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