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Potentiated Hsp104 variants antagonize diverse proteotoxic misfolding events
scientific article published on January 2014
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Statements
instance of
scholarly article
1 reference
stated in
Europe PubMed Central
PMCID
3909490
retrieved
13 October 2017
title
Potentiated Hsp104 variants antagonize diverse proteotoxic misfolding events
(English)
1 reference
stated in
Europe PubMed Central
PMCID
3909490
retrieved
13 October 2017
author
Meredith Jackrel
series ordinal
1
1 reference
stated in
Europe PubMed Central
PMCID
3909490
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24439375%20AND%20SRC:MED&resulttype=core&format=json
retrieved
1 June 2020
Rachel M Stewart
series ordinal
5
1 reference
stated in
Europe PubMed Central
PMCID
3909490
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24439375%20AND%20SRC:MED&resulttype=core&format=json
retrieved
1 June 2020
James Shorter
series ordinal
8
1 reference
stated in
Europe PubMed Central
PMCID
3909490
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24439375%20AND%20SRC:MED&resulttype=core&format=json
retrieved
1 June 2020
Guy A Caldwell
series ordinal
7
object named as
Guy A Caldwell
1 reference
stated in
Europe PubMed Central
PMCID
3909490
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24439375%20AND%20SRC:MED&resulttype=core&format=json
retrieved
1 June 2020
author name string
Morgan E DeSantis
series ordinal
2
1 reference
stated in
Europe PubMed Central
PMCID
3909490
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24439375%20AND%20SRC:MED&resulttype=core&format=json
retrieved
1 June 2020
Bryan A Martinez
series ordinal
3
1 reference
stated in
Europe PubMed Central
PMCID
3909490
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24439375%20AND%20SRC:MED&resulttype=core&format=json
retrieved
1 June 2020
Laura M Castellano
series ordinal
4
1 reference
stated in
Europe PubMed Central
PMCID
3909490
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24439375%20AND%20SRC:MED&resulttype=core&format=json
retrieved
1 June 2020
Kim A Caldwell
series ordinal
6
1 reference
stated in
Europe PubMed Central
PMCID
3909490
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24439375%20AND%20SRC:MED&resulttype=core&format=json
retrieved
1 June 2020
language of work or name
English
0 references
publication date
1 January 2014
1 reference
stated in
Europe PubMed Central
PMCID
3909490
retrieved
13 October 2017
published in
Cell
1 reference
stated in
Europe PubMed Central
PMCID
3909490
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24439375%20AND%20SRC:MED&resulttype=core&format=json
retrieved
1 June 2020
volume
156
1 reference
stated in
Europe PubMed Central
PMCID
3909490
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24439375%20AND%20SRC:MED&resulttype=core&format=json
retrieved
1 June 2020
issue
1-2
1 reference
stated in
Europe PubMed Central
PMCID
3909490
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24439375%20AND%20SRC:MED&resulttype=core&format=json
retrieved
1 June 2020
page(s)
170-182
1 reference
stated in
Europe PubMed Central
PMCID
3909490
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24439375%20AND%20SRC:MED&resulttype=core&format=json
retrieved
1 June 2020
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Yeast reveal a "druggable" Rsp5/Nedd4 network that ameliorates α-synuclein toxicity in neurons.
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PubMed Central
reference URL
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Hsp104 suppresses polyglutamine-induced degeneration post onset in a drosophila MJD/SCA3 model.
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Blessings in disguise: biological benefits of prion-like mechanisms
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Operational plasticity enables hsp104 to disaggregate diverse amyloid and nonamyloid clients.
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The mammalian disaggregase machinery: Hsp110 synergizes with Hsp70 and Hsp40 to catalyze protein disaggregation and reactivation in a cell-free system
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5 June 2018
The elusive middle domain of Hsp104 and ClpB: location and function.
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5 June 2018
A yeast model of FUS/TLS-dependent cytotoxicity
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5 June 2018
Molecular determinants and genetic modifiers of aggregation and toxicity for the ALS disease protein FUS/TLS
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Ataxin-2 intermediate-length polyglutamine expansions are associated with increased risk for ALS
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Prion-like disorders: blurring the divide between transmissibility and infectivity
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TDP-43 is intrinsically aggregation-prone, and amyotrophic lateral sclerosis-linked mutations accelerate aggregation and increase toxicity
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5 June 2018
Hsp104 antagonizes alpha-synuclein aggregation and reduces dopaminergic degeneration in a rat model of Parkinson disease
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5 June 2018
A yeast TDP-43 proteinopathy model: Exploring the molecular determinants of TDP-43 aggregation and cellular toxicity
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Hsp104: a weapon to combat diverse neurodegenerative disorders.
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5 June 2018
Asymmetric deceleration of ClpB or Hsp104 ATPase activity unleashes protein-remodeling activity
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Alpha-synuclein blocks ER-Golgi traffic and Rab1 rescues neuron loss in Parkinson's models
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Dominant gain-of-function mutations in Hsp104p reveal crucial roles for the middle region
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5 June 2018
Global unfolding of a substrate protein by the Hsp100 chaperone ClpA.
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5 June 2018
Disruption of ionic interactions between the nucleotide binding domain 1 (NBD1) and middle (M) domain in Hsp100 disaggregase unleashes toxic hyperactivity and partial independence from Hsp70.
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18 August 2018
Substrate threading through the central pore of the Hsp104 chaperone as a common mechanism for protein disaggregation and prion propagation
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PubMed Central
reference URL
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18 August 2018
Overexpression of yeast hsp104 reduces polyglutamine aggregation and prolongs survival of a transgenic mouse model of Huntington's disease
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reference URL
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Torsin-mediated protection from cellular stress in the dopaminergic neurons of Caenorhabditis elegans.
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Yeast cells provide insight into alpha-synuclein biology and pathobiology
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18 August 2018
Identifiers
DOI
10.1016/J.CELL.2013.11.047
1 reference
stated in
Europe PubMed Central
PMCID
3909490
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24439375%20AND%20SRC:MED&resulttype=core&format=json
retrieved
1 June 2020
PMCID
3909490
1 reference
stated in
Europe PubMed Central
PMCID
3909490
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24439375%20AND%20SRC:MED&resulttype=core&format=json
retrieved
1 June 2020
PubMed ID
24439375
1 reference
stated in
Europe PubMed Central
PMCID
3909490
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24439375%20AND%20SRC:MED&resulttype=core&format=json
retrieved
1 June 2020
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