(Q41908057)

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VER-246608, a novel pan-isoform ATP competitive inhibitor of pyruvate dehydrogenase kinase, disrupts Warburg metabolism and induces context-dependent cytostasis in cancer cells

scientific article published on December 2014

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

13 October 2017

VER-246608, a novel pan-isoform ATP competitive inhibitor of pyruvate dehydrogenase kinase, disrupts Warburg metabolism and induces context-dependent cytostasis in cancer cells (English)

1 reference

Europe PubMed Central

PMC publication ID

13 October 2017

Anna D Staniszewska

2

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25404640%20AND%20SRC:MED&resulttype=core&format=json

9 June 2020

10

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25404640%20AND%20SRC:MED&resulttype=core&format=json

9 June 2020

author name string

Jonathan D Moore

1

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25404640%20AND%20SRC:MED&resulttype=core&format=json

9 June 2020

Terence Shaw

3

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25404640%20AND%20SRC:MED&resulttype=core&format=json

9 June 2020

Jalanie D'Alessandro

4

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25404640%20AND%20SRC:MED&resulttype=core&format=json

9 June 2020

Ben Davis

5

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25404640%20AND%20SRC:MED&resulttype=core&format=json

9 June 2020

Alan Surgenor

6

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25404640%20AND%20SRC:MED&resulttype=core&format=json

9 June 2020

Lisa Baker

7

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25404640%20AND%20SRC:MED&resulttype=core&format=json

9 June 2020

Natalia Matassova

8

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25404640%20AND%20SRC:MED&resulttype=core&format=json

9 June 2020

James Murray

9

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25404640%20AND%20SRC:MED&resulttype=core&format=json

9 June 2020

Paul Brough

11

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25404640%20AND%20SRC:MED&resulttype=core&format=json

9 June 2020

Mike Wood

12

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25404640%20AND%20SRC:MED&resulttype=core&format=json

9 June 2020

Patrick C Mahon

13

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25404640%20AND%20SRC:MED&resulttype=core&format=json

9 June 2020

language of work or name

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publication date

1 December 2014

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Europe PubMed Central

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13 October 2017

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25404640%20AND%20SRC:MED&resulttype=core&format=json

9 June 2020

5

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25404640%20AND%20SRC:MED&resulttype=core&format=json

9 June 2020

24

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25404640%20AND%20SRC:MED&resulttype=core&format=json

9 June 2020

12862-12876

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25404640%20AND%20SRC:MED&resulttype=core&format=json

9 June 2020

PTEN deficiency and mutant p53 confer glucose-addiction to thyroid cancer cells: impact of glucose depletion on cell proliferation, cell survival, autophagy and cell migration.

1 reference

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5 June 2018

Lactate dehydrogenase A in cancer: a promising target for diagnosis and therapy

1 reference

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5 June 2018

A key role for mitochondrial gatekeeper pyruvate dehydrogenase in oncogene-induced senescence.

1 reference

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5 June 2018

Extracellular acidity as favouring factor of tumor progression and metastatic dissemination

1 reference

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5 June 2018

Tyrosine phosphorylation of mitochondrial pyruvate dehydrogenase kinase 1 is important for cancer metabolism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4350332

5 June 2018

p53 negatively regulates transcription of the pyruvate dehydrogenase kinase Pdk2

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4350332

5 June 2018

Targeting cancer metabolism: a therapeutic window opens

1 reference

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5 June 2018

Oncogenic K-Ras decouples glucose and glutamine metabolism to support cancer cell growth

1 reference

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5 June 2018

Overexpression of pyruvate dehydrogenase kinase 3 increases drug resistance and early recurrence in colon cancer

1 reference

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5 June 2018

Stromal-epithelial metabolic coupling in cancer: integrating autophagy and metabolism in the tumor microenvironment

1 reference

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5 June 2018

Regulation of cancer cell metabolism

1 reference

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5 June 2018

The control of the metabolic switch in cancers by oncogenes and tumor suppressor genes

1 reference

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5 June 2018

Context-Dependent Cell Cycle Checkpoint Abrogation by a Novel Kinase Inhibitor

1 reference

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5 June 2018

Glutamine addiction: a new therapeutic target in cancer

1 reference

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5 June 2018

Sodium dichloroacetate selectively targets cells with defects in the mitochondrial ETC.

1 reference

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5 June 2018

Dichloroacetate metabolically targeted therapy defeats cytotoxicity of standard anticancer drugs

1 reference

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5 June 2018

18F-FDG uptake in lung, breast, and colon cancers: molecular biology correlates and disease characterization

1 reference

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5 June 2018

Reversal of the glycolytic phenotype by dichloroacetate inhibits metastatic breast cancer cell growth in vitro and in vivo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4350332

5 June 2018

Understanding the Warburg effect: the metabolic requirements of cell proliferation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4350332

5 June 2018

Targeting lactate-fueled respiration selectively kills hypoxic tumor cells in mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4350332

5 June 2018

Pyruvate dehydrogenase kinase-4 structures reveal a metastable open conformation fostering robust core-free basal activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4350332

5 June 2018

PDK-1 regulates lactate production in hypoxia and is associated with poor prognosis in head and neck squamous cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4350332

5 June 2018

Pyruvate dehydrogenase complex activity controls metabolic and malignant phenotype in cancer cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4350332

5 June 2018

Dichloroacetate induces apoptosis in endometrial cancer cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4350332

5 June 2018

Beyond aerobic glycolysis: transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4350332

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4,5-diarylisoxazole Hsp90 chaperone inhibitors: potential therapeutic agents for the treatment of cancer

1 reference

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5 June 2018

A mitochondria-K+ channel axis is suppressed in cancer and its normalization promotes apoptosis and inhibits cancer growth

1 reference

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5 June 2018

Regulation of the pyruvate dehydrogenase complex

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4350332

5 June 2018

HIF-1 mediates adaptation to hypoxia by actively downregulating mitochondrial oxygen consumption

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4350332

5 June 2018

HIF-1-mediated expression of pyruvate dehydrogenase kinase: a metabolic switch required for cellular adaptation to hypoxia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4350332

5 June 2018

Pyruvate dehydrogenase and pyruvate dehydrogenase kinase expression in non small cell lung cancer and tumor-associated stroma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4350332

5 June 2018

Refinement of macromolecular structures by the maximum-likelihood method

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AZD7545, a novel inhibitor of pyruvate dehydrogenase kinase 2 (PDHK2), activates pyruvate dehydrogenase in vivo and improves blood glucose control in obese (fa/fa) Zucker rats

1 reference

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The finer things in X-ray diffraction data collection

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Effect of extracellular AMP on cell proliferation and metabolism of breast cancer cell lines with high and low glycolytic rates

1 reference

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Pyruvate kinase is a dosage-dependent regulator of cellular amino acid homeostasis

1 reference

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Specific ion influences on self-association of pyruvate dehydrogenase kinase isoform 2 (PDHK2), binding of PDHK2 to the L2 lipoyl domain, and effects of the lipoyl group-binding site inhibitor, Nov3r

1 reference

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1 reference

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based on heuristic

inferred from PubMed ID database lookup

Secondary amides of (R)-3,3,3-trifluoro-2-hydroxy-2-methylpropionic acid as inhibitors of pyruvate dehydrogenase kinase

1 reference

https://pubmed.ncbi.nlm.nih.gov/25404640

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Polymorphism- and species-dependent inactivation of glutathione transferase zeta by dichloroacetate

1 reference

https://pubmed.ncbi.nlm.nih.gov/25404640

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.18632/ONCOTARGET.2656

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25404640%20AND%20SRC:MED&resulttype=core&format=json

9 June 2020

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25404640%20AND%20SRC:MED&resulttype=core&format=json

9 June 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25404640%20AND%20SRC:MED&resulttype=core&format=json

9 June 2020

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