(Q41927920)

English

Relative to quinine and quinidine, their 9-epimers exhibit decreased cytostatic activity and altered heme binding but similar cytocidal activity versus Plasmodium falciparum

scientific article published on 31 October 2012

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

14 October 2017

Relative to quinine and quinidine, their 9-epimers exhibit decreased cytostatic activity and altered heme binding but similar cytocidal activity versus Plasmodium falciparum (English)

1 reference

Europe PubMed Central

PMC publication ID

14 October 2017

Plasmodium falciparum

0 references

author name string

Alexander P Gorka

1

1 reference

Europe PubMed Central

PMC publication ID

14 October 2017

Katy S Sherlach

2

1 reference

Europe PubMed Central

PMC publication ID

14 October 2017

Angel C de Dios

3

1 reference

Europe PubMed Central

PMC publication ID

14 October 2017

Paul D Roepe

4

1 reference

Europe PubMed Central

PMC publication ID

14 October 2017

language of work or name

0 references

publication date

31 October 2012

1 reference

Europe PubMed Central

PMC publication ID

14 October 2017

Antimicrobial Agents and Chemotherapy

1 reference

Europe PubMed Central

PMC publication ID

14 October 2017

57

1 reference

Europe PubMed Central

PMC publication ID

14 October 2017

1

1 reference

Europe PubMed Central

PMC publication ID

14 October 2017

365-374

1 reference

Europe PubMed Central

PMC publication ID

14 October 2017

Cytostatic versus cytocidal activities of chloroquine analogues and inhibition of hemozoin crystal growth.

1 reference

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5 June 2018

Mutation in the Plasmodium falciparum CRT protein determines the stereospecific activity of antimalarial cinchona alkaloids

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3535971

5 June 2018

Investigating the activity of quinine analogues versus chloroquine resistant Plasmodium falciparum

1 reference

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5 June 2018

A major genome region underlying artemisinin resistance in malaria

1 reference

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5 June 2018

Plasmodium falciparum resistance to cytocidal versus cytostatic effects of chloroquine

1 reference

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5 June 2018

PfCRT-mediated drug transport in malarial parasites

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3535971

5 June 2018

The hydroxyl functionality and a rigid proximal N are required for forming a novel non-covalent quinine-heme complex.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3535971

5 June 2018

Reduced digestive vacuolar accumulation of chloroquine is not linked to resistance to chloroquine toxicity

1 reference

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5 June 2018

New medicines to improve control and contribute to the eradication of malaria

1 reference

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5 June 2018

Molecular and physiologic basis of quinoline drug resistance in Plasmodium falciparum malaria

1 reference

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5 June 2018

Synthetic medicinal chemistry of selected antimalarial natural products

1 reference

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5 June 2018

Quinine and chloroquine differentially perturb heme monomer-dimer equilibrium

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3535971

5 June 2018

Mutations in transmembrane domains 1, 4 and 9 of the Plasmodium falciparum chloroquine resistance transporter alter susceptibility to chloroquine, quinine and quinidine

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3535971

5 June 2018

pfmdr1 mutations contribute to quinine resistance and enhance mefloquine and artemisinin sensitivity in Plasmodium falciparum

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3535971

5 June 2018

Quinoline antimalarials decrease the rate of beta-hematin formation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3535971

5 June 2018

Dissecting the loci of low-level quinine resistance in malaria parasites

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3535971

5 June 2018

Novel, rapid, and inexpensive cell-based quantification of antimalarial drug efficacy.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3535971

5 June 2018

Drug resistance-associated pfCRT mutations confer decreased Plasmodium falciparum digestive vacuolar pH.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3535971

5 June 2018

The relationship of physico-chemical properties and structure to the differential antiplasmodial activity of the cinchona alkaloids

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3535971

5 June 2018

Conformational spaces of Cinchona alkaloids.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3535971

5 June 2018

Chloroquine resistance in Plasmodium falciparum malaria parasites conferred by pfcrt mutations

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3535971

5 June 2018

Solution structures of antimalarial drug-heme complexes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3535971

5 June 2018

Alternative mutations at position 76 of the vacuolar transmembrane protein PfCRT are associated with chloroquine resistance and unique stereospecific quinine and quinidine responses in Plasmodium falciparum

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3535971

5 June 2018

Thermodynamic factors controlling the interaction of quinoline antimalarial drugs with ferriprotoporphyrin IX.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3535971

5 June 2018

The interaction of the heme-octapeptide, N-acetylmicroperoxidase-8 with antimalarial drugs: solution studies and modeling by molecular mechanics methods.

1 reference

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5 June 2018

Quinoline anti-malarial drugs inhibit spontaneous formation of beta-haematin (malaria pigment).

1 reference

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5 June 2018

Stereochemical evaluation of the relative activities of the cinchona alkaloids against Plasmodium falciparum

1 reference

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5 June 2018

Human malaria parasites in continuous culture

1 reference

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5 June 2018

Studies on haemin in dimethyl sulphoxide/water mixtures

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3535971

5 June 2018

Antimalarial drugs influence the pH dependent solubility of heme via apparent nucleation phenomena.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3535971

18 August 2018

Identifiers

10.1128/AAC.01234-12

1 reference

Europe PubMed Central

PMC publication ID

14 October 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

14 October 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

14 October 2017

ResearchGate publication ID

0 references

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