(Q41936021)

14 October 2017

title

Solution behavior of hematin under acidic conditions and implications for its interactions with chloroquine (English)

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14 October 2017

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Maria P Crespo

1

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14 October 2017

Leann Tilley

series ordinal

2

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14 October 2017

Nectarios Klonis

series ordinal

3

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14 October 2017

publication date

29 April 2010

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Journal of Biological Inorganic Chemistry

14 October 2017

published in

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14 October 2017

volume

15

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14 October 2017

issue

7

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14 October 2017

page(s)

1009-1022

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Involvement of lipids in ferriprotoporphyrin IX polymerization in malaria

14 October 2017

cites work

1 reference

https://api.crossref.org/works/10.1007%2FS00775-010-0661-Y

A phosphatidylcholine-BODIPY 581/591 conjugate allows mapping of oxidative stress in P. falciparum-infected erythrocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00775-010-0661-Y

Aggregation of ferrihaems. Dimerization and protolytic equilibria of protoferrihaem and deuteroferrihaem in aqueous solution

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00775-010-0661-Y

Solution structures of ferrihaem in some dipolar aprotic solvents and their binary aqueous mixtures

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00775-010-0661-Y

The dimerization of ferrihaemsII. Equilibrium and kinetic studies of mesoferrihaem dimerization

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00775-010-0661-Y

Characterization of chloroquine-hematin mu-oxo dimer binding by isothermal titration calorimetry

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00775-010-0661-Y

The dimerization of ferrihaems. IV. Studies on haematoferrihaem and a general appraisal of the nature and implications of dimerization

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00775-010-0661-Y

Equilibrium and kinetic studies of the aggregation of porphyrins in aqueous solution

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00775-010-0661-Y

Inhibition by chloroquine of a novel haem polymerase enzyme activity in malaria trophozoites

21 January 2018

1 reference

12 December 2020

Quantitative modeling of selective lysosomal targeting for drug design

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12 December 2020

THE STRUCTURE OF ALPHA-CHLOROHEMIN

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12 December 2020

Speciation and structure of ferriprotoporphyrin IX in aqueous solution: spectroscopic and diffusion measurements demonstrate dimerization, but not mu-oxo dimer formation.

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12 December 2020

Identification of the acidic compartment of Plasmodium falciparum-infected human erythrocytes as the target of the antimalarial drug chloroquine

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12 December 2020

Heme activates artemisinin more efficiently than hemin, inorganic iron, or hemoglobin

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12 December 2020

Digestive-vacuole genesis and endocytic processes in the early intraerythrocytic stages of Plasmodium falciparum

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12 December 2020

Structural analysis of the anti-malaria active agent chloroquine under physiological conditions.

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12 December 2020

Food vacuole-associated lipid bodies and heterogeneous lipid environments in the malaria parasite, Plasmodium falciparum

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12 December 2020

The pH of the Plasmodium falciparum digestive vacuole: holy grail or dead-end trail?

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12 December 2020

Carbon isosteres of the 4-aminopyridine substructure of chloroquine: effects on pK(a), hematin binding, inhibition of hemozoin formation, and parasite growth

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12 December 2020

A structural model for heme in high-spin ferric hemoproteins. Iron atom centering, porphinato core expansion, and molecular stereochemistry of high-spin diaquo(meso-tetraphenylporphinato)iron(III) perchlorate

1 reference

12 December 2020

Evidence that haem iron in the malaria parasite is not needed for the antimalarial effects of artemisinin

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12 December 2020

Dual labeling with a far red probe permits analysis of growth and oxidative stress in P. falciparum-infected erythrocytes

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12 December 2020

Inhibition of the peroxidative degradation of haem as the basis of action of chloroquine and other quinoline antimalarials

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12 December 2020

Haemozoin (beta-haematin) biomineralization occurs by self-assembly near the lipid/water interface

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12 December 2020

Interaction of antimalarial drugs with hemin

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12 December 2020

Definition of an electronic profile of compounds with inhibitory activity against hematin aggregation in malaria parasite

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12 December 2020

Malarial haemozoin/beta-haematin supports haem polymerization in the absence of protein

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12 December 2020

Hemoglobin catabolism and iron utilization by malaria parasites

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12 December 2020

Four plasmepsins are active in the Plasmodium falciparum food vacuole, including a protease with an active-site histidine

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12 December 2020

Preparation of protohemin monomethyl ester

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12 December 2020

The mechanism of beta-hematin formation in acetate solution. Parallels between hemozoin formation and biomineralization processes

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12 December 2020

Theories on malarial pigment formation and quinoline action

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12 December 2020

Antimalarials increase vesicle pH in Plasmodium falciparum

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12 December 2020

Three-dimensional reconstruction of the feeding process of the malaria parasite

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12 December 2020

The crystal structure of halofantrine-ferriprotoporphyrin IX and the mechanism of action of arylmethanol antimalarials

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12 December 2020

Structural specificity of chloroquine-hematin binding related to inhibition of hematin polymerization and parasite growth

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12 December 2020

Structure-function relationships in aminoquinolines: effect of amino and chloro groups on quinoline-hematin complex formation, inhibition of beta-hematin formation, and antiplasmodial activity.

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12 December 2020

Haem polymerization in malaria

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12 December 2020

An assessment of drug-haematin binding as a mechanism for inhibition of haematin polymerisation by quinoline antimalarials

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12 December 2020

The role of neutral lipid nanospheres in Plasmodium falciparum haem crystallization.

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12 December 2020

Evaluation of pH during cytostomal endocytosis and vacuolar catabolism of haemoglobin in Plasmodium falciparum

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12 December 2020

Speciation of ferriprotoporphyrin IX in aqueous and mixed aqueous solution is controlled by solvent identity, pH, and salt concentration

1 reference

12 December 2020

Haemozoin: from melatonin pigment to drug target, diagnostic tool, and immune modulator

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12 December 2020

Fate of haem iron in the malaria parasite Plasmodium falciparum

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12 December 2020

Quinine and chloroquine differentially perturb heme monomer-dimer equilibrium

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12 December 2020

Drug resistance-associated pfCRT mutations confer decreased Plasmodium falciparum digestive vacuolar pH.

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12 December 2020

Photosensitization by antimalarial drugs.

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12 December 2020

Structure-function relationships in chloroquine and related 4-aminoquinoline antimalarials

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12 December 2020

Solution structures of antimalarial drug-heme complexes

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12 December 2020

Antimalarial drugs influence the pH dependent solubility of heme via apparent nucleation phenomena.

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12 December 2020

Inhibition of glutathione-dependent degradation of heme by chloroquine and amodiaquine as a possible basis for their antimalarial mode of action

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12 December 2020

4-N-, 4-S-, and 4-O-chloroquine analogues: influence of side chain length and quinolyl nitrogen pKa on activity vs chloroquine resistant malaria

1 reference

12 December 2020

Novel bisquinoline antimalarials. Synthesis, antimalarial activity, and inhibition of haem polymerisation.

1 reference

12 December 2020

10.1007/S00775-010-0661-Y

Identifiers

DOI

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14 October 2017

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