(Q41952334)

English

Aldosterone stimulates elastogenesis in cardiac fibroblasts via mineralocorticoid receptor-independent action involving the consecutive activation of Galpha13, c-Src, the insulin-like growth factor-I receptor, and phosphatidylinositol 3-kinase/Akt

scientific article published on 16 April 2009

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scholarly article

1 reference

Europe PubMed Central

14 October 2017

Aldosterone stimulates elastogenesis in cardiac fibroblasts via mineralocorticoid receptor-independent action involving the consecutive activation of Galpha13, c-Src, the insulin-like growth factor-I receptor, and phosphatidylinositol 3-kinase/Akt (English)

1 reference

Europe PubMed Central

14 October 2017

author name string

Severa Bunda

1

1 reference

Europe PubMed Central

14 October 2017

Yanting Wang

2

1 reference

Europe PubMed Central

14 October 2017

Thomas F Mitts

3

1 reference

Europe PubMed Central

14 October 2017

Peter Liu

4

1 reference

Europe PubMed Central

14 October 2017

Sara Arab

5

1 reference

Europe PubMed Central

14 October 2017

Majid Arabkhari

6

1 reference

Europe PubMed Central

14 October 2017

Aleksander Hinek

7

1 reference

Europe PubMed Central

14 October 2017

language of work or name

0 references

publication date

16 April 2009

1 reference

Europe PubMed Central

14 October 2017

number of pages

15

1 reference

based on heuristic

inferred from page(s)

Journal of Biological Chemistry

1 reference

Europe PubMed Central

14 October 2017

284

1 reference

Europe PubMed Central

14 October 2017

16633-16647

1 reference

Europe PubMed Central

14 October 2017

24

1 reference

Europe PubMed Central

14 October 2017

Association of the membrane estrogen receptor, GPR30, with breast tumor metastasis and transactivation of the epidermal growth factor receptor

1 reference

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5 June 2018

Classic versus non-classic receptors for nongenomic mineralocorticoid responses: emerging evidence

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2713569

5 June 2018

Aldosterone induces elastin production in cardiac fibroblasts through activation of insulin-like growth factor-I receptors in a mineralocorticoid receptor-independent manner

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2713569

5 June 2018

Galpha12/13-mediated up-regulation of TRPC6 negatively regulates endothelin-1-induced cardiac myofibroblast formation and collagen synthesis through nuclear factor of activated T cells activation.

1 reference

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Rapid stimulation of tyrosine phosphorylation signals downstream of G-protein-coupled receptors for thromboxane A2 in human platelets.

1 reference

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5 June 2018

Targeted knockdown of G protein subunits selectively prevents receptor-mediated modulation of effectors and reveals complex changes in non-targeted signaling proteins

1 reference

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5 June 2018

Aldosterone and the kidney: rapid regulation of renal microcirculation

1 reference

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5 June 2018

Nongenomic actions of aldosterone: physiological or pathophysiological role?

1 reference

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5 June 2018

Aldosterone receptor antagonism in heart failure

1 reference

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5 June 2018

The new biology of aldosterone

1 reference

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Cardioprotective stress response in the human fetal heart

1 reference

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Src kinase regulation by phosphorylation and dephosphorylation

1 reference

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5 June 2018

Early nongenomic events in aldosterone action in renal collecting duct cells: PKCalpha activation, mineralocorticoid receptor phosphorylation, and cross-talk with the genomic response.

1 reference

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5 June 2018

Gα12 and Gα13 as key regulatory mediator in signal transduction

1 reference

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The molecular target of rapamycin (mTOR) as a therapeutic target against cancer

1 reference

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The biochemistry and physiology of metallic fluoride: action, mechanism, and implications

1 reference

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5 June 2018

G alpha 13-mediated transformation and apoptosis are permissively dependent on basal ERK activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2713569

5 June 2018

Eplerenone, a selective aldosterone blocker, in patients with left ventricular dysfunction after myocardial infarction

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2713569

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Identification, classification, and partial characterization of genes in humans and other vertebrates homologous to a fish membrane progestin receptor

1 reference

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5 June 2018

N-terminal short sequences of alpha subunits of the G12 family determine selective coupling to receptors.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2713569

5 June 2018

Cloning, expression, and characterization of a membrane progestin receptor and evidence it is an intermediary in meiotic maturation of fish oocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2713569

5 June 2018

Estrogen action via the G protein-coupled receptor, GPR30: stimulation of adenylyl cyclase and cAMP-mediated attenuation of the epidermal growth factor receptor-to-MAPK signaling axis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2713569

5 June 2018

Rho/ROCK pathway contributes to the activation of extracellular signal-regulated kinase/GATA-4 during myocardial cell hypertrophy

1 reference

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5 June 2018

SP600125, an anthrapyrazolone inhibitor of Jun N-terminal kinase

1 reference

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5 June 2018

Rapid and non-genomic reduction of intracellular [Ca(2+)] induced by aldosterone in human bronchial epithelium

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2713569

5 June 2018

Treatment of congestive heart failure: interfering the aldosterone-cardiac extracellular matrix relationship.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2713569

5 June 2018

Role of p190RhoGAP in beta 2 integrin regulation of RhoA in human neutrophils

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2713569

5 June 2018

Estrogen-induced activation of Erk-1 and Erk-2 requires the G protein-coupled receptor homolog, GPR30, and occurs via trans-activation of the epidermal growth factor receptor through release of HB-EGF

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2713569

5 June 2018

G13alpha-mediated PYK2 activation. PYK2 is a mediator of G13alpha -induced serum response element-dependent transcription.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2713569

5 June 2018

The effect of spironolactone on morbidity and mortality in patients with severe heart failure. Randomized Aldactone Evaluation Study Investigators

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2713569

5 June 2018

Activation of G12/G13 results in shape change and Rho/Rho-kinase-mediated myosin light chain phosphorylation in mouse platelets

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2713569

5 June 2018

Expression of functional angiotensin-converting enzyme and AT1 receptors in cultured human cardiac fibroblasts

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2713569

5 June 2018

Extracellular signal-regulated kinase activity is sustained early during human cytomegalovirus infection

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2713569

5 June 2018

Non-genomic action of the mineralocorticoid aldosterone on cytosolic sodium in cultured kidney cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2713569

5 June 2018

Direct stimulation of the guanine nucleotide exchange activity of p115 RhoGEF by Galpha13

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2713569

5 June 2018

Calcium sensitization of smooth muscle mediated by a Rho-associated protein kinase in hypertension

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2713569

5 June 2018

Src phosphorylates the insulin-like growth factor type I receptor on the autophosphorylation sites. Requirement for transformation by src.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2713569

5 June 2018

A role for Pyk2 and Src in linking G-protein-coupled receptors with MAP kinase activation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2713569

5 June 2018

Characterization of RAFTK, a novel focal adhesion kinase, and its integrin-dependent phosphorylation and activation in megakaryocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2713569

5 June 2018

Insulin-like growth factor-I regulates transcription of the elastin gene

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2713569

5 June 2018

The 67-kD elastin/laminin-binding protein is related to an enzymatically inactive, alternatively spliced form of beta-galactosidase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2713569

5 June 2018

Differential structural requirements for specific binding of nonpeptide and peptide antagonists to the AT1 angiotensin receptor. Identification of amino acid residues that determine binding of the antihypertensive drug losartan.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2713569

5 June 2018

Mineralocorticoids, hypertension, and cardiac fibrosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2713569

5 June 2018

67-kD elastin-binding protein is a protective "companion" of extracellular insoluble elastin and intracellular tropoelastin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2713569

5 June 2018

Distinctive effects of the carboxyl-terminal sequence of the insulin-like growth factor I receptor on its signaling functions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2713569

5 June 2018

Molecular and cellular aspects of the insulin-like growth factor I receptor

1 reference

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1 reference

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PD 098059 is a specific inhibitor of the activation of mitogen-activated protein kinase kinase in vitro and in vivo

1 reference

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Pathological hypertrophy and cardiac interstitium. Fibrosis and renin-angiotensin-aldosterone system

1 reference

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5 June 2018

Aldosterone-specific membrane receptors and rapid non-genomic actions of mineralocorticoids

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2713569

5 June 2018

The signalling of AT2 and the influence on the collagen metabolism of AT2 receptor in adult rat cardiac fibroblasts.

1 reference

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Analysis of aldosterone-induced differential receptor-independent protein patterns using 2D-electrophoresis and mass spectrometry.

1 reference

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1 reference

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Relative contribution of G-protein-coupled pathways to protease-activated receptor-mediated Akt phosphorylation in platelets

1 reference

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18 August 2018

Nongenomic effects of aldosterone in the human heart: interaction with angiotensin II.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2713569

18 August 2018

Aldosterone stimulates collagen gene expression and synthesis via activation of ERK1/2 in rat renal fibroblasts

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2713569

18 August 2018

Mechanism for aldosterone potentiation of angiotensin II-stimulated rat arterial smooth muscle cell proliferation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2713569

18 August 2018

Aldosterone potentiates angiotensin II-induced signaling in vascular smooth muscle cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2713569

18 August 2018

Steroid-protein conjugates. I. Preparation and characterization of conjugates of bovine serum albumin with testosterone and with cortisone.

1 reference

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18 August 2018

The pp60c-Src inhibitor PP1 is non-competitive against ATP.

1 reference

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18 August 2018

beta-adrenergic stimulation of rat cardiac fibroblasts enhances induction of nitric-oxide synthase by interleukin-1beta via message stabilization

1 reference

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18 August 2018

Insulin-like growth factor-I regulates transcription of the elastin gene through a putative retinoblastoma control element. A role for Sp3 acting as a repressor of elastin gene transcription.

1 reference

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18 August 2018

Effect of tyrosine mutations on the kinase activity and transforming potential of an oncogenic human insulin-like growth factor I receptor.

1 reference

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18 August 2018

Differential blockade of central effects of angiotensin II by AT2-receptor antagonists.

1 reference

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18 August 2018

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1 reference

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18 August 2018

Limitation of Excessive Extracellular Matrix Turnover May Contribute to Survival Benefit of Spironolactone Therapy in Patients With Congestive Heart Failure

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.008748

21 January 2018

Activation of elastin transcription by transforming growth factor-beta in human lung fibroblasts

1 reference

https://pubmed.ncbi.nlm.nih.gov/19372600

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rapid nongenomic effects of aldosterone in mineralocorticoid-receptor-knockout mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/19372600

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Enhanced insulin-induced mitogenesis and mitogen-activated protein kinase activities in mutant insulin receptors with substitution of two COOH-terminal tyrosine autophosphorylation sites by phenylalanine

1 reference

https://pubmed.ncbi.nlm.nih.gov/19372600

12 December 2020

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inferred from PubMed ID database lookup

The ductus arteriosus migratory smooth muscle cell phenotype processes tropoelastin to a 52-kDa product associated with impaired assembly of elastic laminae

1 reference

https://pubmed.ncbi.nlm.nih.gov/19372600

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Antifibrotic effects of spironolactone in preventing myocardial fibrosis in systemic arterial hypertension

1 reference

https://pubmed.ncbi.nlm.nih.gov/19372600

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Non-classical receptors for aldosterone in plasma membranes from pig kidneys

1 reference

https://pubmed.ncbi.nlm.nih.gov/19372600

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Novel membrane receptors for aldosterone in human lymphocytes: a 50 kDa protein on SDS-PAGE

1 reference

https://pubmed.ncbi.nlm.nih.gov/19372600

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Transcriptional regulation of the elastin gene by insulin-like growth factor-I involves disruption of Sp1 binding. Evidence for the role of Rb in mediating Sp1 binding in aortic smooth muscle cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/19372600

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Characterization and solubilization of novel aldosterone-binding proteins in porcine liver microsomes

1 reference

https://pubmed.ncbi.nlm.nih.gov/19372600

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of angiotensin II and aldosterone on collagen gene expression and protein turnover in cardiac fibroblasts

1 reference

https://pubmed.ncbi.nlm.nih.gov/19372600

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Estrogen receptor alpha interacts with Galpha13 to drive actin remodeling and endothelial cell migration via the RhoA/Rho kinase/moesin pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/19372600

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1074/JBC.M109.008748

1 reference

Europe PubMed Central

14 October 2017

1 reference

Europe PubMed Central

14 October 2017

1 reference

Europe PubMed Central

14 October 2017

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