(Q419618)

Deferoxamine (English)

DrugBank

image of molecular model or crystal lattice model

17 November 2015

Deferoxamine-2D-skeletal.png
1,600 × 265; 26 KB

0 references

Deferoxamine-3D-vdW.png
1,100 × 303; 110 KB

depicts

space-filling model

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mass

560.353363 dalton

1 reference

deferoxamine (English)

4 October 2016

chemical formula

C₂₅H₄₈N₆O₈

1 reference

deferoxamine (English)

19 November 2016

canonical SMILES

CC(=O)N(CCCCCNC(=O)CCC(=O)N(CCCCCNC(=O)CCC(=O)N(CCCCCN)O)O)O

1 reference

World Health Organisation international non-proprietary name

deferoxamine (English)

19 November 2016

1 reference

14 February 2018

deferoxamine (English)

1 reference

desferrioxamine B (English)

4 October 2016

found in taxon

Streptomyces mirabilis

3 references

Streptomyces coelicolor as an expression host for heterologous gene clusters.

Integrated metabolomics approach facilitates discovery of an unpredicted natural product suite from Streptomyces coelicolor M145.

Volatile Compounds Influence Exploration and Microbial Community Dynamics by Altering Iron Availability

Streptomyces venezuelae

3 references

Streptomyces coelicolor as an expression host for heterologous gene clusters.

Integrated metabolomics approach facilitates discovery of an unpredicted natural product suite from Streptomyces coelicolor M145.

Volatile Compounds Influence Exploration and Microbial Community Dynamics by Altering Iron Availability

Streptomyces argillaceus

1 reference

Uncovering production of specialized metabolites by Streptomyces argillaceus: Activation of cryptic biosynthesis gene clusters using nutritional and genetic approaches.

Streptomyces coelicolor

6 references

Identification of a cluster of genes that directs desferrioxamine biosynthesis in Streptomyces coelicolor M145.

Deletion of the signalling molecule synthase ScbA has pleiotropic effects on secondary metabolite biosynthesis, morphological differentiation and primary metabolism in Streptomyces coelicolor A3(2)

Two overlapping antiparallel genes encoding the iron regulator DmdR1 and the Adm proteins control siderophore [correction of sedephore] and antibiotic biosynthesis in Streptomyces coelicolor A3(2).

The MtrAB two-component system controls antibiotic production in Streptomyces coelicolor A3(2).

Transcriptional regulation of the desferrioxamine gene cluster of Streptomyces coelicolor is mediated by binding of DmdR1 to an iron box in the promoter of the desA gene

Interspecies interactions stimulate diversification of the Streptomyces coelicolor secreted metabolome

Streptomyces lydicus

1 reference

Complete genome sequencing and antibiotics biosynthesis pathways analysis of Streptomyces lydicus 103.

Streptomyces chartreusis

1 reference

The secreted metabolome of Streptomyces chartreusis and implications for bacterial chemistry.

Streptomyces pilosus

4 references

Production of desferrioxamine B (Desferal) using corn steep liquor in Streptomyces pilosus

Characterization of an iron-regulated promoter involved in desferrioxamine B synthesis in Streptomyces pilosus: repressor-binding site and homology to the diphtheria toxin gene promoter

Optimization of culture medium to increase the production of desferrioxamine B (Desferal) in Streptomyces pilosus

Characterization of the iron-regulated desA promoter of Streptomyces pilosus as a system for controlled gene expression in actinomycetes

Streptomyces malaysiense

1 reference

Streptomyces malaysiense sp. nov.: A novel Malaysian mangrove soil actinobacterium with antioxidative activity and cytotoxic potential against human cancer cell lines

Streptomyces malaysiensis

1 reference

Streptomyces malaysiense sp. nov.: A novel Malaysian mangrove soil actinobacterium with antioxidative activity and cytotoxic potential against human cancer cell lines

Streptomyces wadayamensis

1 reference

Genome Sequence of Streptomyces wadayamensis Strain A23, an Endophytic Actinobacterium from Citrus reticulata

Streptomyces xinghaiensis

1 reference

Genome mining of Streptomyces xinghaiensis NRRL B-24674T for the discovery of the gene cluster involved in anticomplement activities and detection of novel xiamycin analogs

Moorea producens

1 reference

Wewakazole B, a Cytotoxic Cyanobactin from the Cyanobacterium Moorea producens Collected in the Red Sea.

Streptomyces albidoflavus

6 references

The MtrAB two-component system controls antibiotic production in Streptomyces coelicolor A3(2).

Deletion of the signalling molecule synthase ScbA has pleiotropic effects on secondary metabolite biosynthesis, morphological differentiation and primary metabolism in Streptomyces coelicolor A3(2)

Two overlapping antiparallel genes encoding the iron regulator DmdR1 and the Adm proteins control siderophore [correction of sedephore] and antibiotic biosynthesis in Streptomyces coelicolor A3(2).

Identification of a cluster of genes that directs desferrioxamine biosynthesis in Streptomyces coelicolor M145.

Interspecies interactions stimulate diversification of the Streptomyces coelicolor secreted metabolome

Transcriptional regulation of the desferrioxamine gene cluster of Streptomyces coelicolor is mediated by binding of DmdR1 to an iron box in the promoter of the desA gene

Streptomyces griseus

1 reference

Genome sequence of the streptomycin-producing microorganism Streptomyces griseus IFO 13350

medical condition treated

1 reference

13 December 2016

1 reference

13 December 2016

1 reference

rare hereditary hemochromatosis

13 December 2016

1 reference

beta-thalassemia HBB/LCRB

2 October 2018

1 reference

2 October 2018

thalassemia

1 reference

2 October 2018

myelodysplastic syndrome

1 reference

imported from Wikimedia project

2 October 2018

pregnancy category

US pregnancy category C

1 reference

English Wikipedia

LiverTox likelihood score

LiverTox toxicity likelihood category E

1 reference

8 April 2021

https://www.ncbi.nlm.nih.gov/books/n/livertox/Deferoxamine

27 December 2017

1 reference

5 March 2018

1 reference

Medical Subject Headings

15 March 2018

0 references

Deferoxamine

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Identifiers

InChI

InChI=1S/C25H48N6O8/c1-21(32)29(37)18-9-3-6-16-27-22(33)12-14-25(36)31(39)20-10-4-7-17-28-23(34)11-13-24(35)30(38)19-8-2-5-15-26/h37-39H,2-20,26H2,1H3,(H,27,33)(H,28,34)

1 reference

deferoxamine (English)

UBQYURCVBFRUQT-UHFFFAOYSA-N

19 November 2016

InChIKey

2 references

deferoxamine (English)

19 November 2016

ChEBI release 2020-09-01

CAS Registry Number

70-51-9

2 references

deferoxamine (English)

UBQYURCVBFRUQT-UHFFFAOYSA-N

19 November 2016

InChIKey

9 April 2021

https://commonchemistry.cas.org/detail?cas_rn=70-51-9

1 reference

Deferoxamine (English)

19 November 2016

1 reference

deferoxamine (English)

19 November 2016

Reaxys registry number

2514118

1 reference

desferrioxamine B (English)

4 October 2016

ChEBI ID

4356

mapping relation type

1 reference

DEFEROXAMINE (English)

19 November 2016

1 reference

splash10-0udl-0892110000-487a5822b41da03f0948

DEFEROXAMINE (English)

19 November 2016

1 reference

0 references

splash10-0007-9621400000-9b6a525f53e7f320f714

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splash10-05ne-1943110000-cfdaf16ce07341d78b59

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splash10-0ikc-1771190000-39b4db7f6f66f4b9474e

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splash10-001i-0111190000-7dabe399b61bdc270ec0

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splash10-03di-0011291100-947a326a94f014b19a3c

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splash10-03di-0003290000-fa657f35b9c02a21ebbf

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HSDB ID

3311

1 reference

Hazardous Substances Data Bank

28 October 2019

DESFERRIOXAMINE (English)

10 May 2021

1 reference

Mapping file of InChIStrings, InChIKeys and DTXSIDs for the EPA CompTox Dashboard

DSSTOX compound identifier

0 references

0 references

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200-738-5

1 reference

deferoxamine (English)

ECHA Substance Infocard ID

19 November 2016

100.000.671

1 reference

ECHA Substance Infocard database

ECHA Substance Infocard ID

100.000.671

27 December 2018

Deferoxamine (English)

quotation

CAS no.: 70-51-9 (English)

1 reference

Deferoxamine (English)

17 November 2015

Deferoxamine

0 references

0 references

0 references

0 references

1 reference

deferoxamine (English)

19 November 2016

1 reference

Deferoxamine (English)

Human Metabolome Database ID

19 November 2016

HMDB0014884

1 reference

based on heuristic

inferred from InChIKey

1 reference

deferoxamine (English)

PatientsLikeMe treatment ID

19 November 2016

Natural Product Atlas ID

NPA009012

1 reference

based on heuristic

inferred from InChIKey

0 references

1 reference

deferoxamine (English)

19 November 2016

0 references

1 reference

1 reference

desferrioxamine B (English)

4 October 2016

1 reference

http://www.lipidmaps.org/rest/compound/lm_id/LM/all/download

desferrioxamine B (English)

4 October 2016

1 reference

30 June 2018

1 reference

6 April 2020

0 references

electronic Essential Medicines List medicine ID

40

1 reference

reference URL

https://list.essentialmeds.org/medicines/40

https://docs.openalex.org/download-snapshot/snapshot-data-format

eEML - Electronic Essential Medicines List (English)

23 October 2021

1 reference

28 October 2013

Microsoft Academic ID

0 references

1 reference

26 January 2022

1 reference

1 reference

deferoxamine (English)