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New strategies to inhibit KEAP1 and the Cul3-based E3 ubiquitin ligases.
scientific article published on February 2014
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Europe PubMed Central
PMCID
3935762
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24450635%20AND%20SRC:MED&resulttype=core&format=json
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5 March 2020
title
New strategies to inhibit KEAP1 and the Cul3-based E3 ubiquitin ligases
(English)
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Europe PubMed Central
PMCID
3935762
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24450635%20AND%20SRC:MED&resulttype=core&format=json
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5 March 2020
author
Peter Canning
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1
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Europe PubMed Central
PMCID
3935762
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24450635%20AND%20SRC:MED&resulttype=core&format=json
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5 March 2020
author name string
Alex N Bullock
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2
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Europe PubMed Central
PMCID
3935762
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24450635%20AND%20SRC:MED&resulttype=core&format=json
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5 March 2020
publication date
1 February 2014
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Europe PubMed Central
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3935762
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24450635%20AND%20SRC:MED&resulttype=core&format=json
retrieved
5 March 2020
published in
Biochemical Society Transactions
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Europe PubMed Central
PMCID
3935762
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24450635%20AND%20SRC:MED&resulttype=core&format=json
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5 March 2020
volume
42
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Europe PubMed Central
PMCID
3935762
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24450635%20AND%20SRC:MED&resulttype=core&format=json
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5 March 2020
issue
1
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Europe PubMed Central
PMCID
3935762
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24450635%20AND%20SRC:MED&resulttype=core&format=json
retrieved
5 March 2020
page(s)
103-107
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Europe PubMed Central
PMCID
3935762
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24450635%20AND%20SRC:MED&resulttype=core&format=json
retrieved
5 March 2020
copyright license
Creative Commons Attribution 3.0 Unported
start time
25 July 2019
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cites work
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Mutations in KLHL40 are a frequent cause of severe autosomal-recessive nemaline myopathy
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Toward clinical application of the Keap1-Nrf2 pathway
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Small molecules inhibit the interaction of Nrf2 and the Keap1 Kelch domain through a non-covalent mechanism
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Kelch-like 3 and Cullin 3 regulate electrolyte homeostasis via ubiquitination and degradation of WNK4
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Crystal structure of KLHL3 in complex with Cullin3
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The CUL3-KLHL3 E3 ligase complex mutated in Gordon's hypertension syndrome interacts with and ubiquitylates WNK isoforms: disease-causing mutations in KLHL3 and WNK4 disrupt interaction
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The CUL3-KLHL18 ligase regulates mitotic entry and ubiquitylates Aurora-A.
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Small molecule modulators of Keap1-Nrf2-ARE pathway as potential preventive and therapeutic agents
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Ubiquitin-dependent regulation of COPII coat size and function
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A Cullin3-KLHL20 Ubiquitin ligase-dependent pathway targets PML to potentiate HIF-1 signaling and prostate cancer progression
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Ubiquitin ligase activity of Cul3-KLHL7 protein is attenuated by autosomal dominant retinitis pigmentosa causative mutation
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1 reference
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1 reference
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1 reference
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1 reference
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PubMed Central
reference URL
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1 reference
stated in
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Structure of the Cand1-Cul1-Roc1 complex reveals regulatory mechanisms for the assembly of the multisubunit cullin-dependent ubiquitin ligases
1 reference
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PubMed Central
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Oxidative stress sensor Keap1 functions as an adaptor for Cul3-based E3 ligase to regulate proteasomal degradation of Nrf2
1 reference
stated in
PubMed Central
reference URL
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1 reference
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PubMed Central
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Keap1-dependent proteasomal degradation of transcription factor Nrf2 contributes to the negative regulation of antioxidant response element-driven gene expression
1 reference
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PubMed Central
reference URL
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PubMed Central
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Mechanisms underlying ubiquitination
1 reference
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PubMed Central
reference URL
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The gene encoding gigaxonin, a new member of the cytoskeletal BTB/kelch repeat family, is mutated in giant axonal neuropathy
1 reference
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PubMed Central
reference URL
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5 June 2018
Crystal structure of the BTB domain from PLZF
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3935762
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5 June 2018
The ubiquitin-proteasome pathway: the complexity and myriad functions of proteins death
1 reference
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PubMed Central
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5 June 2018
Peptide inhibitors of the Keap1-Nrf2 protein-protein interaction with improved binding and cellular activity
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3935762
retrieved
18 August 2018
Dimerization of substrate adaptors can facilitate cullin-mediated ubiquitylation of proteins by a "tethering" mechanism: a two-site interaction model for the Nrf2-Keap1 complex.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3935762
retrieved
18 August 2018
Identifiers
DOI
10.1042/BST20130215
1 reference
stated in
Europe PubMed Central
PMCID
3935762
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24450635%20AND%20SRC:MED&resulttype=core&format=json
retrieved
5 March 2020
PMCID
3935762
1 reference
stated in
Europe PubMed Central
PMCID
3935762
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24450635%20AND%20SRC:MED&resulttype=core&format=json
retrieved
5 March 2020
PubMed ID
24450635
1 reference
stated in
Europe PubMed Central
PMCID
3935762
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24450635%20AND%20SRC:MED&resulttype=core&format=json
retrieved
5 March 2020
ResearchGate publication ID
259875461
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