(Q41988367)

English

Desensitization of chemical activation by auxiliary subunits: convergence of molecular determinants critical for augmenting KCNQ1 potassium channels

scientific article published on 19 May 2008

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

14 October 2017

Desensitization of chemical activation by auxiliary subunits: convergence of molecular determinants critical for augmenting KCNQ1 potassium channels (English)

1 reference

Europe PubMed Central

PMC publication ID

14 October 2017

desensitization

1 reference

based on heuristic

inferred from title

author name string

Zhaobing Gao

1

1 reference

Europe PubMed Central

PMC publication ID

14 October 2017

Qiaojie Xiong

2

1 reference

Europe PubMed Central

PMC publication ID

14 October 2017

Haiyan Sun

3

1 reference

Europe PubMed Central

PMC publication ID

14 October 2017

Min Li

4

1 reference

Europe PubMed Central

PMC publication ID

14 October 2017

language of work or name

0 references

publication date

19 May 2008

1 reference

Europe PubMed Central

PMC publication ID

14 October 2017

Journal of Biological Chemistry

1 reference

Europe PubMed Central

PMC publication ID

14 October 2017

283

1 reference

Europe PubMed Central

PMC publication ID

14 October 2017

33

1 reference

Europe PubMed Central

PMC publication ID

14 October 2017

22649-22658

1 reference

Europe PubMed Central

PMC publication ID

14 October 2017

Combinatorial augmentation of voltage-gated KCNQ potassium channels by chemical openers

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2504881

5 June 2018

Counting membrane-embedded KCNE beta-subunits in functioning K+ channel complexes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2504881

5 June 2018

Activation of Kv7 (KCNQ) voltage-gated potassium channels by synthetic compounds

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2504881

5 June 2018

Molecular pharmacology and therapeutic potential of neuronal Kv7-modulating drugs

1 reference

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5 June 2018

TARP auxiliary subunits switch AMPA receptor antagonists into partial agonists

1 reference

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5 June 2018

Zinc pyrithione-mediated activation of voltage-gated KCNQ potassium channels rescues epileptogenic mutants

1 reference

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5 June 2018

Randomized, multicenter, dose-ranging trial of retigabine for partial-onset seizures

1 reference

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5 June 2018

Inactivation as a new regulatory mechanism for neuronal Kv7 channels

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2504881

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2504881

5 June 2018

Ancillary subunits and stimulation frequency determine the potency of chromanol 293B block of the KCNQ1 potassium channel.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2504881

5 June 2018

Differential roles of S6 domain hinges in the gating of KCNQ potassium channels.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2504881

5 June 2018

Interaction of KCNE subunits with the KCNQ1 K+ channel pore

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2504881

5 June 2018

Investigating the putative glycine hinge in Shaker potassium channel.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2504881

5 June 2018

In vitro molecular interactions and distribution of KCNE family with KCNQ1 in the human heart

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2504881

5 June 2018

Retigabine: chemical synthesis to clinical application.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2504881

5 June 2018

hKCNE4 inhibits the hKCNQ1 potassium current without affecting the activation kinetics

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2504881

5 June 2018

Discovery of a small molecule activator of the human ether-a-go-go-related gene (HERG) cardiac K+ channel

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2504881

5 June 2018

In silico activation of KcsA K+ channel by lateral forces applied to the C-termini of inner helices

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2504881

5 June 2018

KCNE1 binds to the KCNQ1 pore to regulate potassium channel activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2504881

5 June 2018

Potassium channel subunits encoded by the KCNE gene family: physiology and pathophysiology of the MinK-related peptides (MiRPs).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2504881

5 June 2018

The open pore conformation of potassium channels

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2504881

5 June 2018

Mitochondrial ATP-sensitive potassium channels inhibit apoptosis induced by oxidative stress in cardiac cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2504881

5 June 2018

Structural determinants of KvLQT1 control by the KCNE family of proteins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2504881

5 June 2018

Molecular basis for differential sensitivity of KCNQ and I(Ks) channels to the cognitive enhancer XE991.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2504881

5 June 2018

A constitutively open potassium channel formed by KCNQ1 and KCNE3

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2504881

5 June 2018

KCNE1-like gene is deleted in AMME contiguous gene syndrome: identification and characterization of the human and mouse homologs.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2504881

5 June 2018

Dysfunction of delayed rectifier potassium channels in an inherited cardiac arrhythmia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2504881

5 June 2018

MiRP1 forms IKr potassium channels with HERG and is associated with cardiac arrhythmia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2504881

5 June 2018

Single-channel properties of IKs potassium channels

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2504881

5 June 2018

Single-channel characteristics of wild-type IKs channels and channels formed with two minK mutants that cause long QT syndrome

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2504881

5 June 2018

A novel benzodiazepine that activates cardiac slow delayed rectifier K+ currents

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2504881

5 June 2018

Voltage-dependent inactivation of the human K+ channel KvLQT1 is eliminated by association with minimal K+ channel (minK) subunits

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2504881

5 June 2018

SWISS-MODEL and the Swiss-PdbViewer: an environment for comparative protein modeling

1 reference

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5 June 2018

Mutation of the gene for IsK associated with both Jervell and Lange-Nielsen and Romano-Ward forms of Long-QT syndrome

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2504881

5 June 2018

Mutations in the hminK gene cause long QT syndrome and suppress IKs function

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2504881

5 June 2018

IsK and KvLQT1: mutation in either of the two subunits of the slow component of the delayed rectifier potassium channel can cause Jervell and Lange-Nielsen syndrome

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2504881

5 June 2018

Molecular mechanism and functional significance of the MinK control of the KvLQT1 channel activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2504881

5 June 2018

Coassembly of K(V)LQT1 and minK (IsK) proteins to form cardiac I(Ks) potassium channel

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2504881

5 June 2018

K(V)LQT1 and lsK (minK) proteins associate to form the I(Ks) cardiac potassium current

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2504881

5 June 2018

Multiple mechanisms in the long-QT syndrome. Current knowledge, gaps, and future directions. The SADS Foundation Task Force on LQTS.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2504881

5 June 2018

Two components of the delayed rectifier K+ current in ventricular myocytes of the guinea pig type. Theoretical formulation and their role in repolarization

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2504881

5 June 2018

A mechanistic link between an inherited and an acquired cardiac arrhythmia: HERG encodes the IKr potassium channel

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2504881

5 June 2018

HERG, a Human Inward Rectifier in the Voltage-Gated Potassium Channel Family

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2504881

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Modulation of single cardiac sodium channels by DPI 201-106.

1 reference

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Retigabine (ASTA Medica).

1 reference

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Molecular determinants of KCNQ (Kv7) K+ channel sensitivity to the anticonvulsant retigabine.

1 reference

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The new anticonvulsant retigabine favors voltage-dependent opening of the Kv7.2 (KCNQ2) channel by binding to its activation gate

1 reference

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Meclofenamic acid and diclofenac, novel templates of KCNQ2/Q3 potassium channel openers, depress cortical neuron activity and exhibit anticonvulsant properties

1 reference

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Auxiliary subunits of Shaker-type potassium channels

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2504881

18 August 2018

Pharmacological activation of normal and arrhythmia-associated mutant KCNQ1 potassium channels

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2504881

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The oxidant thimerosal modulates gating behavior of KCNQ1 by interaction with the channel outer shell.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2504881

18 August 2018

Location and orientation of minK within the I(Ks) potassium channel complex

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2504881

18 August 2018

Identification of specific pore residues mediating KCNQ1 inactivation. A novel mechanism for long QT syndrome

1 reference

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Evidence for a cardiac ion channel mutation underlying drug-induced QT prolongation and life-threatening arrhythmias

1 reference

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18 August 2018

Increase of the single-channel conductance of KvLQT1 potassium channels induced by the association with minK.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2504881

18 August 2018

Inhibition of IKs in guinea pig cardiac myocytes and guinea pig IsK channels by the chromanol 293B.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2504881

18 August 2018

Novel mutations in KvLQT1 that affect Iks activation through interactions with Isk

1 reference

https://pubmed.ncbi.nlm.nih.gov/18490447

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Blocker protection in the pore of a voltage-gated K+ channel and its structural implications

1 reference

https://pubmed.ncbi.nlm.nih.gov/18490447

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

KCNE4 can co-associate with the I(Ks) (KCNQ1-KCNE1) channel complex

1 reference

https://pubmed.ncbi.nlm.nih.gov/18490447

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Potassium channel gating observed with site-directed mass tagging

1 reference

https://pubmed.ncbi.nlm.nih.gov/18490447

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1074/JBC.M802426200

1 reference

Europe PubMed Central

PMC publication ID

14 October 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

14 October 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

14 October 2017

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