(Q419964)

Gene Ontology release 2019-11-16

response to camptothecin

subject has role

reactant

1 reference

Gene Ontology release 2019-11-16

has use

medication

0 references

chemical structure

Camptothecin.png
591 × 373; 9 KB

1 reference

imported from Wikimedia project

German Wikipedia

Camptothecin structure.svg
512 × 297; 22 KB

0 references

mass

348.111 dalton

1 reference

camptothecin (English)

19 October 2016

2 references

inferred from InChIKey

based on heuristic

inferred from InChI

chemical formula

C₂₀H₁₆N₂O₄

1 reference

camptothecin (English)

18 November 2016

canonical SMILES

CCC1(C2=C(COC1=O)C(=O)N3CC4=CC5=CC=CC=C5N=C4C3=C2)O

1 reference

camptothecin (English)

18 November 2016

isomeric SMILES

CC[C@@]1(C2=C(COC1=O)C(=O)N3CC4=CC5=CC=CC=C5N=C4C3=C2)O

1 reference

camptothecin (English)

18 November 2016

found in taxon

Camptotheca acuminata

17 references

Quinoline alkaloids from Camptotheca acuminata

Drought-induced in vivo synthesis of camptothecin in Camptotheca acuminata seedlings

Influence of soil fertilization, plant spacing, and cokppicing on growth, stomatal conductance, abscisic acid, and camptothecin levels in Camptotheca acuminata seedlings

Sites of accumulation of the antitumor alkaloid camptothecin in Camptotheca acuminata

Sustained harvest of camptothecin from the leaves of Camptotheca acuminata

Studies on the Constituents ofCamptotheca AcuminataDecne, II. The Constituents of Fresh Fruits,

Micropropagation of Camptotheca acuminata decaisne from axillary buds, shoot tips, and seed embryos in a tissue culture system

Isolation and characterization of a presumed biosynthetic precursor of camptothecin from extracts of Camptotheca acuminata

Effects of alkaloid precursor feeding on a Camptotheca acuminata cell line

Rapid micro-assay of camptothecin in Camptotheca acuminata

Camptothecin yield and distribution within Camptotheca acuminata trees cultivated in Louisiana

Camptothecin production in Camptotheca acuminata seedlings in response to shading and flooding

Effect of artificial reconstitution of the interaction between the plant Camptotheca acuminata and the fungal endophyte Fusarium solani on camptothecin biosynthesis

Plant antitumor agents. 22. Isolation of 11-hydroxycamptothecin from Camptotheca acuminata Decne: total synthesis and biological activity

Enhancement of tanshinone production in Salvia miltiorrhiza hairy root culture by Ag+ elicitation and nutrient feeding

Plant Antitumor Agents. I. The Isolation and Structure of Camptothecin, a Novel Alkaloidal Leukemia and Tumor Inhibitor from Camptotheca acuminata1,2

Camptothecin, a selective plant growth regulator

Nothapodytes nimmoniana

10 references

Constituents and cytotoxic principles of Nothapodytes foetida

Constituents of Nothapodytes foetida

Quantitative analysis of camptothecin derivatives in Nothapodytes foetida using 1H-NMR method

Growth and production of camptothecin by cell suspension cultures of Nothapodytes foetida

The quinoline alkaloids camptothecin and 9-methoxycamptothecin from tissue cultures and mature trees of Nothapodytes foetida

An endophytic fungus from Nothapodytes foetida that produces camptothecin

Occurrence of 5-Methoxy-1-oxo-Tetrahydro-β-Carboline in IndianNothapodytes foetida—An Important Clue to the Biogenetic Formation of Camptothecins1

Isolation, Characterization and Chemoenzymatic Sythesis Of 9-Methoxy-20-(s)-Mappicine, A New Constituent of Nothapodytes Foetida

Alkaloids of Mappia foetida

Distribution of anticancer drug camptothecin in Nothapodytes foetida

Ophiorrhiza pumila

8 references

Pumiloside and deoxypumiloside; plausible intermediates of camptothecin biosynthesis

Feasible production of camptothecin by hairy root culture of Ophiorrhiza pumila

Anthraquinones from Ophiorrhiza pumila tissue and cell cultures

Constituents of regenerated plants of Ophiorrhiza pumila; formation of a new glycocamptothecin and predominant formation of (3R)-deoxypumiloside over (3S)-congener

Camptothecin biosynthetic genes in hairy roots of Ophiorrhiza pumila: cloning, characterization and differential expression in tissues and by stress compounds

Structure of ophiorines A and B; novel type gluco indole alkaloids isolated from ophiorrhiza spp.

Camptothecin Production by in Vitro Cultures of Ophiorrhiza liukiuensis and O. kuroiwai

Merrilliodendron megacarpum

1 reference

Plant Anticancer Agents XXI. Constituents ofMerrilliodendron megacarpum*

Ophiorrhiza liukiuensis

3 references

Camptothecins and two new monoterpene glucosides from Ophiorrhiza liukiuensis

Camptothecins and Two New Monoterpene Glucosides from Ophiorrhiza liukiuensis.

Camptothecin Production by in Vitro Cultures of Ophiorrhiza liukiuensis and O. kuroiwai

Mappia foetida

2 references

An endophytic fungus from Nothapodytes foetida that produces camptothecin

Alkaloids of Mappia foetida

Pyrenacantha klaineana

1 reference

Use of COMPARE analysis to discover new natural product drugs: isolation of camptothecin and 9-methoxycamptothecin from a new source

Fusarium solani

2 references

Effect of artificial reconstitution of the interaction between the plant Camptotheca acuminata and the fungal endophyte Fusarium solani on camptothecin biosynthesis

Endophytic fungal strains of Fusarium solani, from Apodytes dimidiata E. Mey. ex Arn (Icacinaceae) produce camptothecin, 10-hydroxycamptothecin and 9-methoxycamptothecin

Didymochlaena truncatula

1 reference

Cytotoxic and other compounds from Didymochlaena truncatula from the Madagascar rain forest

Rinorea anguifera

1 reference

DNA topoisomerase I inhibitors from Rinorea anguifera

Murraya paniculata

1 reference

Effects of β-caryophyllene and Murraya paniculata essential oil in the murine hepatoma cells and in the bacteria and fungi 24-h time-kill curve studies.

Casearia sylvestris

1 reference

Novel bioactive clerodane diterpenoids from the leaves and twigs of Casearia sylvestris

Penicillium concentricum

1 reference

Halogenated Compounds from Directed Fermentation of Penicillium concentricum, an Endophytic Fungus of the Liverwort Trichocolea tomentella

Archidendron lucidum

1 reference

Cytotoxic triterpenoid saponins acylated with monoterpenic acid from Pithecellobium lucidum

Ophiorrhiza kuroiwae

3 references

Camptothecins and two new monoterpene glucosides from Ophiorrhiza liukiuensis

Camptothecins and Two New Monoterpene Glucosides from Ophiorrhiza liukiuensis.

Camptothecin Production by in Vitro Cultures of Ophiorrhiza liukiuensis and O. kuroiwai

Mappia nimmoniana

2 references

Alkaloids of Mappia foetida

An endophytic fungus from Nothapodytes foetida that produces camptothecin

Ophiorrhiza mungos

1 reference

Camptothecin Production by in Vitro Cultures of Ophiorrhiza liukiuensis and O. kuroiwai

Ophiorrhiza shendurunii

1 reference

Recent studies on chemical constituents of Ophiorrhiza plants

Ophiorrhiza pectinata

1 reference

Recent studies on chemical constituents of Ophiorrhiza plants

Tabernaemontana alternifolia

2 references

Anticancer indole alkaloids of Ervatamia heyneana

Tabernaemontana L. (Apocynaceae): A review of its taxonomy, phytochemistry, ethnobotany and pharmacology

Mostuea brunonis

1 reference

20-O-beta-glucopyranosyl camptothecin from mostuea brunonis: A potential camptothecin pro-drug with improved solubility

Tabernaemontana heyneana

1 reference

Tabernaemontana L. (Apocynaceae): A review of its taxonomy, phytochemistry, ethnobotany and pharmacology

Tolypocladium

1 reference

Prenylated Indole Diterpene Alkaloids from a Mine-Soil-Derived Tolypocladium sp

Phaeoacremonium

1 reference

Lactone Derivatives Produced by a Phaeoacremonium sp., an Endophytic Fungus from Senna spectabilis.

subject has role

phytogenic antineoplastic agents

1 reference

Medical Subject Headings

MeSH descriptor ID

D002166

topoisomerase I inhibitor

15 March 2018

1 reference

InChI=1S/C20H16N2O4/c1-2-20(25)14-8-16-17-12(7-11-5-3-4-6-15(11)21-17)9-22(16)18(23)13(14)10-26-19(20)24/h3-8,25H,2,9-10H2,1H3/t20-/m0/s1

Medical Subject Headings

15 March 2018

Camptothecin

0 references

Identifiers

InChI

1 reference

camptothecin (English)

18 November 2016

2 references

camptothecin (English)

18 November 2016

ChEBI release 2020-09-01

CAS Registry Number

7689-03-4

2 references

Global Substance Registration System

UNII

XT3Z54Z28A

camptothecin (English)

18 November 2016

https://commonchemistry.cas.org/detail?cas_rn=7689-03-4

9 April 2021

1 reference

Camptothecin (English)

18 November 2016

2 references

camptothecin (English)

18 November 2016

Reaxys registry number

6075662

1 reference

camptothecin (English)

19 October 2016

ChEBI ID

27656

mapping relation type

2 references

CAMPTOTHECIN (English)

18 November 2016

International Chemical Identifier

InChI

InChI=1S/C20H16N2O4/c1-2-20(25)14-8-16-17-12(7-11-5-3-4-6-15(11)21-17)9-22(16)18(23)13(14)10-26-19(20)24/h3-8,25H,2,9-10H2,1H3/t20-/m0/s1

1 reference

CAMPTOTHECIN (English)

18 November 2016

2 references

inferred from InChIKey

splash10-0a4i-0009000000-4129fefe58da5c4aa6d7

1 reference

0 references

splash10-004i-0009000000-fadb0b298c05417c7128

0 references

splash10-0002-0149000000-a4935b6e6f5d88de2237

0 references

DSSTox substance ID

DTXSID0030956

2 references

Mapping file of InChIStrings, InChIKeys and DTXSIDs for the EPA CompTox Dashboard

DSSTOX compound identifier

0 references

0 references

616-407-7

0 references

ECHA Substance Infocard ID

100.113.172

1 reference

reference URL

http://echa.europa.eu/de/information-on-chemicals/registered-substances

MeSH descriptor ID

D002166

subject named as

Camptothecin

0 references

0 references

1 reference

1 reference

Global Substance Registration System

camptothecin (English)

19 October 2016

2 references

UNII

XT3Z54Z28A

camptothecin (English)

18 November 2016

Natural Product Atlas ID

NPA018135

2 references

based on heuristic

inferred from InChIKey

https://docs.openalex.org/download-snapshot/snapshot-data-format

0 references

0 references

0 references

1 reference

28 October 2013

1 reference

9 July 2020

Microsoft Academic ID

0 references

1 reference

26 January 2022

1 reference

inferred by common MeSH mappings on source and on Wikidata

1T8I (English)

19 October 2016

1 reference

UMLS 2023