(Q4201951)

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P13612

integrin alpha chain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P13612

Integrin alpha, N-terminal

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P13612

Integrin alpha beta-propellor, protein family

1 reference

Integrin alpha-2, protein family

1 reference

FG-GAP repeat, protein family

1 reference

Integrin alpha chain, C-terminal cytoplasmic region, conserved site, protein family

1 reference

1 reference

13 November 2019

1 reference

13 November 2019

9 references

8 April 2019

Propolypeptide of von Willebrand factor is a novel ligand for very late antigen-4 integrin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13612

8 April 2019

alpha4beta1- and alpha6beta1-integrins are functional receptors for midkine, a heparin-binding growth factor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13612

8 April 2019

Abl-interactor-1 (Abi1) has a role in cardiovascular and placental development and is a binding partner of the alpha4 integrin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13612

8 April 2019

A family of beta 7 integrins on human mucosal lymphocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13612

8 April 2019

Involvement of transmembrane domain interactions in signal transduction by alpha/beta integrins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13612

8 April 2019

Structural specializations of α(4)β(7), an integrin that mediates rolling adhesion

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13612

8 April 2019

Matrix metalloproteinase-9 promotes chronic lymphocytic leukemia b cell survival through its hemopexin domain

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13612

8 April 2019

Binding of paxillin to alpha4 integrins modifies integrin-dependent biological responses

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13612

8 April 2019

Selective integrin endocytosis is driven by interactions between the integrin α-chain and AP2.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13612

protein antigen binding

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13612

metal ion binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13612

1 reference

8 April 2019

antigen binding

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13612

fibronectin binding

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13612

cell adhesion molecule binding

JAML, a novel protein with characteristics of a junctional adhesion molecule, is induced during differentiation of myeloid leukemia cells

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13612

8 April 2019

Disruption of disulfide restriction at integrin knees induces activation and ligand-independent signaling of α₄β₇

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13612

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13612

coreceptor activity

1 reference

8 April 2019

Integrins αvβ3 and α4β1 act as coreceptors for fractalkine, and the integrin-binding defective mutant of fractalkine is an antagonist of CX3CR1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13612

C-X3-C chemokine binding

1 reference

8 April 2019

Integrins αvβ3 and α4β1 act as coreceptors for fractalkine, and the integrin-binding defective mutant of fractalkine is an antagonist of CX3CR1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13612

protein heterodimerization activity

1 reference

8 April 2019

Regulated expression of p150,95 (CD11c/CD18; alpha X/beta 2) and VLA-4 (CD49d/CD29; alpha 4/beta 1) integrins during myeloid cell differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13612

cell component

extracellular exosome

3 references

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P13612&geneProductId=UniProtKB:P13612

17 October 2017

Proteomic and biochemical analyses of human B cell-derived exosomes. Potential implications for their function and multivesicular body formation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P13612&geneProductId=UniProtKB:P13612

17 October 2017

MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis

http://www.ebi.ac.uk/QuickGO/annotations?protein=P13612&geneProductId=UniProtKB:P13612

integral component of membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13612

1 reference

8 April 2019

focal adhesion

1 reference

17 October 2017

Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P13612&geneProductId=UniProtKB:P13612

cell surface

5 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13612

8 April 2019

Disruption of disulfide restriction at integrin knees induces activation and ligand-independent signaling of α₄β₇

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13612

8 April 2019

CCL25 and CCL28 promote alpha4 beta7-integrin-dependent adhesion of lymphocytes to MAdCAM-1 under shear flow

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13612

8 April 2019

Integrin expression and integrin-mediated adhesion in vitro of human multipotent stromal cells (MSCs) to endothelial cells from various blood vessels

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13612

8 April 2019

Vascular cell adhesion molecule-1 and the integrin VLA-4 mediate adhesion of human B cell precursors to cultured bone marrow adherent cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13612

integrin alpha4-beta7 complex

integrin complex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13612

1 reference

8 April 2019

plasma membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13612

3 references

8 April 2019

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13612

8 April 2019

JAML, a novel protein with characteristics of a junctional adhesion molecule, is induced during differentiation of myeloid leukemia cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13612

focal adhesion

1 reference

8 April 2019

Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13612

growth cone

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13612

soma

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13612

extracellular exosome

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13612

8 April 2019

MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13612

8 April 2019

Proteomic and biochemical analyses of human B cell-derived exosomes. Potential implications for their function and multivesicular body formation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13612

protein-containing complex

1 reference

8 April 2019

Regulated expression of p150,95 (CD11c/CD18; alpha X/beta 2) and VLA-4 (CD49d/CD29; alpha 4/beta 1) integrins during myeloid cell differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13612

endodermal cell differentiation

biological process

IEP

1 reference

8 April 2019

Regulation of endodermal differentiation of human embryonic stem cells through integrin-ECM interactions

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13612

IEP

B cell differentiation

IC

1 reference

8 April 2019

Vascular cell adhesion molecule-1 and the integrin VLA-4 mediate adhesion of human B cell precursors to cultured bone marrow adherent cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13612

positive regulation of T cell migration

IC

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13612

extracellular matrix organization

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13612

1 reference

8 April 2019

heterotypic cell-cell adhesion

1 reference

17 October 2017

CCL25 and CCL28 promote alpha4 beta7-integrin-dependent adhesion of lymphocytes to MAdCAM-1 under shear flow

http://www.ebi.ac.uk/QuickGO/annotations?protein=P13612&geneProductId=UniProtKB:P13612

substrate adhesion-dependent cell spreading

1 reference

8 April 2019

Disruption of disulfide restriction at integrin knees induces activation and ligand-independent signaling of α₄β₇

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13612

cellular response to cytokine stimulus

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13612

cell-matrix adhesion involved in ameboidal cell migration

1 reference

8 April 2019

Disruption of disulfide restriction at integrin knees induces activation and ligand-independent signaling of α₄β₇

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13612

cell-matrix adhesion

leukocyte tethering or rolling

1 reference

8 April 2019

CCL25 and CCL28 promote alpha4 beta7-integrin-dependent adhesion of lymphocytes to MAdCAM-1 under shear flow

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13612

diapedesis

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13612

regulation of immune response

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13612

1 reference

8 April 2019

integrin-mediated signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13612

1 reference

8 April 2019

leukocyte migration

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13612

1 reference

8 April 2019

positive regulation of leukocyte tethering or rolling

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13612

positive regulation of leukocyte cell-cell adhesion

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13612

positive regulation of leukocyte migration

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13612

import into cell

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13612

leukocyte cell-cell adhesion

1 reference

8 April 2019

Vascular cell adhesion molecule-1 and the integrin VLA-4 mediate adhesion of human B cell precursors to cultured bone marrow adherent cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13612

negative regulation of protein homodimerization activity

1 reference

8 April 2019

JAML, a novel protein with characteristics of a junctional adhesion molecule, is induced during differentiation of myeloid leukemia cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13612

clathrin-dependent extracellular exosome endocytosis

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13612

receptor clustering

1 reference

8 April 2019

Disruption of disulfide restriction at integrin knees induces activation and ligand-independent signaling of α₄β₇

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13612

cell-cell adhesion mediated by integrin

1 reference

8 April 2019

beta-amyloid-induced migration of monocytes across human brain endothelial cells involves RAGE and PECAM-1.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13612

heterotypic cell-cell adhesion

axonogenesis involved in innervation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13612

cell-cell adhesion in response to extracellular stimulus

1 reference

8 April 2019

beta-amyloid-induced migration of monocytes across human brain endothelial cells involves RAGE and PECAM-1.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13612

cellular response to amyloid-beta

1 reference

8 April 2019

beta-amyloid-induced migration of monocytes across human brain endothelial cells involves RAGE and PECAM-1.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13612

positive regulation of vascular endothelial cell proliferation

1 reference

8 April 2019

MiR-30s Family Inhibit the Proliferation and Apoptosis in Human Coronary Artery Endothelial Cells Through Targeting the 3'UTR Region of ITGA4 and PLCG1.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13612

neuron projection extension

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13612

positive regulation of endothelial cell apoptotic process

1 reference

8 April 2019

MiR-30s Family Inhibit the Proliferation and Apoptosis in Human Coronary Artery Endothelial Cells Through Targeting the 3'UTR Region of ITGA4 and PLCG1.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13612

D12.776.543.750.705.408.100.450

Gene Atlas image

PBB GE ITGA4 213416 at fs.png
732 × 530; 11 KB

0 references

Identifiers

MeSH descriptor ID

D039441

subject named as

Integrin alpha4

0 references

MeSH tree code

0 references

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

13 November 2019

1 reference

1 reference

1 reference

1 reference

28 October 2013

Microsoft Academic ID

0 references

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

inferred by common MeSH mappings on source and on Wikidata

1 reference

UMLS 2023