(Q42100360)

English

1-(1-acetyl-piperidin-4-yl)-3-adamantan-1-yl-urea (AR9281) as a potent, selective, and orally available soluble epoxide hydrolase inhibitor with efficacy in rodent models of hypertension and dysglycemia

scientific article published on 13 December 2010

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scholarly article

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Europe PubMed Central

PMC publication ID

16 October 2017

1-(1-acetyl-piperidin-4-yl)-3-adamantan-1-yl-urea (AR9281) as a potent, selective, and orally available soluble epoxide hydrolase inhibitor with efficacy in rodent models of hypertension and dysglycemia (English)

1 reference

Europe PubMed Central

PMC publication ID

16 October 2017

Soluble epoxide hydrolase

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D Euan MacIntyre

20

object named as

D Euan MacIntyre

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Europe PubMed Central

PMC publication ID

16 October 2017

author name string

Sampath-Kumar Anandan

1

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16 October 2017

Heather Kay Webb

2

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16 October 2017

Dawn Chen

3

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16 October 2017

Yi-Xin Jim Wang

4

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16 October 2017

Basker R Aavula

5

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16 October 2017

Sylvaine Cases

6

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16 October 2017

Ying Cheng

7

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16 October 2017

Zung N Do

8

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16 October 2017

Upasana Mehra

9

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16 October 2017

Vinh Tran

10

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16 October 2017

Jon Vincelette

11

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16 October 2017

Joanna Waszczuk

12

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16 October 2017

Kathy White

13

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16 October 2017

Kenneth R Wong

14

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16 October 2017

Le-Ning Zhang

15

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16 October 2017

Paul D Jones

16

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16 October 2017

Bruce D Hammock

17

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16 October 2017

Dinesh V Patel

18

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16 October 2017

Randall Whitcomb

19

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16 October 2017

James Sabry

21

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Europe PubMed Central

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16 October 2017

Richard Gless

22

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16 October 2017

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publication date

13 December 2010

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Europe PubMed Central

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16 October 2017

Bioorganic & Medicinal Chemistry Letters

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Europe PubMed Central

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16 October 2017

21

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Europe PubMed Central

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16 October 2017

3

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Europe PubMed Central

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16 October 2017

983-988

1 reference

Europe PubMed Central

PMC publication ID

16 October 2017

1-Aryl-3-(1-acylpiperidin-4-yl)urea inhibitors of human and murine soluble epoxide hydrolase: structure-activity relationships, pharmacokinetics, and reduction of inflammatory pain.

1 reference

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29 May 2018

Rapid synthesis of an array of trisubstituted urea-based soluble epoxide hydrolase inhibitors facilitated by a novel solid-phase method

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3529200

29 May 2018

Inhibition or deletion of soluble epoxide hydrolase prevents hyperglycemia, promotes insulin secretion, and reduces islet apoptosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3529200

29 May 2018

Soluble epoxide hydrolase inhibitors: a patent review

1 reference

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29 May 2018

Inflammatory lipid mediators in adipocyte function and obesity.

1 reference

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29 May 2018

Reduced NO-cGMP signaling contributes to vascular inflammation and insulin resistance induced by high-fat feeding.

1 reference

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29 May 2018

Design and synthesis of substituted nicotinamides as inhibitors of soluble epoxide hydrolase

1 reference

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29 May 2018

Structure-based optimization of arylamides as inhibitors of soluble epoxide hydrolase

1 reference

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29 May 2018

Epoxyeicosatrienoic acid agonist rescues the metabolic syndrome phenotype of HO-2-null mice

1 reference

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29 May 2018

Insulin resistance and endothelial dysfunction: Are epoxyeicosatrienoic acids the link?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3529200

29 May 2018

Discovery of a highly potent, selective, and bioavailable soluble epoxide hydrolase inhibitor with excellent ex vivo target engagement

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3529200

29 May 2018

Expression and regulation of soluble epoxide hydrolase in adipose tissue

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3529200

29 May 2018

Soluble epoxide hydrolase, a target with multiple opportunities for cardiovascular drug discovery

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3529200

29 May 2018

Discovery of spirocyclic secondary amine-derived tertiary ureas as highly potent, selective and bioavailable soluble epoxide hydrolase inhibitors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3529200

29 May 2018

Soluble epoxide hydrolase and epoxyeicosatrienoic acids modulate two distinct analgesic pathways

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3529200

29 May 2018

Soluble epoxide hydrolase inhibitors reduce the development of atherosclerosis in apolipoprotein e-knockout mouse model

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3529200

29 May 2018

Genetic analysis of the soluble epoxide hydrolase gene, EPHX2, in subclinical cardiovascular disease in the Diabetes Heart Study

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3529200

29 May 2018

Attenuation of cisplatin nephrotoxicity by inhibition of soluble epoxide hydrolase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3529200

29 May 2018

Epoxygenases and peroxisome proliferator-activated receptors in mammalian vascular biology

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3529200

29 May 2018

Discovery and metabolic stabilization of potent and selective 2-amino-N-(adamant-2-yl) acetamide 11beta-hydroxysteroid dehydrogenase type 1 inhibitors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3529200

29 May 2018

Beyond vasodilatation: non-vasomotor roles of epoxyeicosatrienoic acids in the cardiovascular system

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3529200

29 May 2018

Prevention and reversal of cardiac hypertrophy by soluble epoxide hydrolase inhibitors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3529200

29 May 2018

Design of bioavailable derivatives of 12-(3-adamantan-1-yl-ureido)dodecanoic acid, a potent inhibitor of the soluble epoxide hydrolase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3529200

29 May 2018

Action of epoxyeicosatrienoic acids on cellular function

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3529200

29 May 2018

Inhibition of soluble epoxide hydrolase reduces LPS-induced thermal hyperalgesia and mechanical allodynia in a rat model of inflammatory pain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3529200

29 May 2018

Synthesis and SAR of conformationally restricted inhibitors of soluble epoxide hydrolase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3529200

29 May 2018

Emerging role of epoxyeicosatrienoic acids in coronary vascular function

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3529200

29 May 2018

An epoxide hydrolase inhibitor, 12-(3-adamantan-1-yl-ureido)dodecanoic acid (AUDA), reduces ischemic cerebral infarct size in stroke-prone spontaneously hypertensive rats

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3529200

29 May 2018

An orally active epoxide hydrolase inhibitor lowers blood pressure and provides renal protection in salt-sensitive hypertension

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3529200

29 May 2018

Epoxide hydrolase and epoxygenase metabolites as therapeutic targets for renal diseases

1 reference

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29 May 2018

Soluble epoxide hydrolase is a therapeutic target for acute inflammation

1 reference

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29 May 2018

Fluorescent substrates for soluble epoxide hydrolase and application to inhibition studies

1 reference

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29 May 2018

Attenuation of tobacco smoke-induced lung inflammation by treatment with a soluble epoxide hydrolase inhibitor

1 reference

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29 May 2018

Epoxyeicosatrienoic acids (EETs): metabolism and biochemical function

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29 May 2018

Anti-inflammatory properties of cytochrome P450 epoxygenase-derived eicosanoids.

1 reference

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29 May 2018

Pharmacokinetics and metabolism of rimantadine hydrochloride in mice and dogs

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29 May 2018

Eicosapentaenoic acid increases cytochrome P-450 2J2 gene expression and epoxyeicosatrienoic acid production via peroxisome proliferator-activated receptor γ in endothelial cells

1 reference

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17 August 2018

A strategy of employing aminoheterocycles as amide mimics to identify novel, potent and bioavailable soluble epoxide hydrolase inhibitors

1 reference

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17 August 2018

Discovery of 3,3-disubstituted piperidine-derived trisubstituted ureas as highly potent soluble epoxide hydrolase inhibitors

1 reference

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17 August 2018

Inhibition of soluble epoxide hydrolase attenuated atherosclerosis, abdominal aortic aneurysm formation, and dyslipidemia

1 reference

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17 August 2018

Effects of epoxyeicosatrienoic acids on levels of eNOS phosphorylation and relevant signaling transduction pathways involved

1 reference

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17 August 2018

Association of soluble epoxide hydrolase gene polymorphism with insulin resistance in type 2 diabetic patients.

1 reference

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17 August 2018

Soluble epoxide hydrolase is a main effector of angiotensin II-induced hypertension

1 reference

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17 August 2018

Soluble epoxide hydrolase inhibition protects the kidney from hypertension-induced damage.

1 reference

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17 August 2018

Soluble epoxide hydrolase regulates hydrolysis of vasoactive epoxyeicosatrienoic acids

1 reference

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Toll-like receptor-4 mediates vascular inflammation and insulin resistance in diet-induced obesity

1 reference

https://pubmed.ncbi.nlm.nih.gov/21211973

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The Soluble Epoxide Hydrolase Inhibitor AR9281 Decreases Blood Pressure, Ameliorates Renal Injury and Improves Vascular Function in Hypertension

1 reference

https://pubmed.ncbi.nlm.nih.gov/21211973

12 December 2020

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inferred from PubMed ID database lookup

Urinary metabolites of rimantadine in humans

1 reference

https://pubmed.ncbi.nlm.nih.gov/21211973

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regio- and enantiofacial selectivity of epoxyeicosatrienoic acid hydration by cytosolic epoxide hydrolase

1 reference

https://pubmed.ncbi.nlm.nih.gov/21211973

12 December 2020

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Functional implications of a newly characterized pathway of 11,12-epoxyeicosatrienoic acid metabolism in arterial smooth muscle

1 reference

https://pubmed.ncbi.nlm.nih.gov/21211973

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Metabolism of a novel CCK-B antagonist in rat, dog and human liver microsomes

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https://pubmed.ncbi.nlm.nih.gov/21211973

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Identifiers

10.1016/J.BMCL.2010.12.042

1 reference

Europe PubMed Central

PMC publication ID

16 October 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

16 October 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

16 October 2017

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