(Q42115423)

English

Talin-driven inside-out activation mechanism of platelet αIIbβ3 integrin probed by multimicrosecond, all-atom molecular dynamics simulations

scientific article published on 25 September 2014

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scholarly article

1 reference

Europe PubMed Central

16 October 2017

Talin-driven inside-out activation mechanism of platelet αIIbβ3 integrin probed by multimicrosecond, all-atom molecular dynamics simulations (English)

1 reference

Europe PubMed Central

16 October 2017

4

1 reference

Europe PubMed Central

16 October 2017

author name string

Davide Provasi

1

1 reference

Europe PubMed Central

16 October 2017

Ana Negri

2

1 reference

Europe PubMed Central

16 October 2017

Barry S Coller

3

1 reference

Europe PubMed Central

16 October 2017

language of work or name

0 references

publication date

25 September 2014

1 reference

Europe PubMed Central

16 October 2017

1 reference

Europe PubMed Central

16 October 2017

82

1 reference

Europe PubMed Central

16 October 2017

3231-3240

1 reference

Europe PubMed Central

16 October 2017

12

1 reference

Europe PubMed Central

16 October 2017

All-atom empirical potential for molecular modeling and dynamics studies of proteins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5156318

29 May 2018

Conformational changes in talin on binding to anionic phospholipid membranes facilitate signaling by integrin transmembrane helices

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5156318

29 May 2018

On the activation of integrin αIIbβ3: outside-in and inside-out pathways

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5156318

29 May 2018

Integrin bi-directional signaling across the plasma membrane

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5156318

29 May 2018

Talin activates integrins by altering the topology of the β transmembrane domain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5156318

29 May 2018

Integrin αIIbβ3 inside-out activation: an in situ conformational analysis reveals a new mechanism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5156318

29 May 2018

Kindlins, integrin activation and the regulation of talin recruitment to αIIbβ3.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5156318

29 May 2018

Affinity of talin-1 for the β3-integrin cytosolic domain is modulated by its phospholipid bilayer environment.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5156318

29 May 2018

Intact alphaIIbbeta3 integrin is extended after activation as measured by solution X-ray scattering and electron microscopy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5156318

29 May 2018

Molecular mechanism of inside-out integrin regulation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5156318

29 May 2018

Multiscale simulations suggest a mechanism for integrin inside-out activation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5156318

29 May 2018

NMR analysis of the IIb 3 cytoplasmic interaction suggests a mechanism for integrin regulation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5156318

29 May 2018

Tests of integrin transmembrane domain homo-oligomerization during integrin ligand binding and signaling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5156318

29 May 2018

The structure of the talin/integrin complex at a lipid bilayer: an NMR and MD simulation study

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5156318

29 May 2018

The final steps of integrin activation: the end game

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5156318

29 May 2018

Recreation of the terminal events in physiological integrin activation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5156318

29 May 2018

Structure of an integrin IIb 3 transmembrane-cytoplasmic heterocomplex provides insight into integrin activation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5156318

29 May 2018

The structure of an integrin/talin complex reveals the basis of inside-out signal transduction.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5156318

29 May 2018

The structure of a receptor with two associating transmembrane domains on the cell surface: integrin alphaIIbbeta3.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5156318

29 May 2018

The structure of the integrin alphaIIbbeta3 transmembrane complex explains integrin transmembrane signalling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5156318

29 May 2018

Kindlin-1 and -2 directly bind the C-terminal region of beta integrin cytoplasmic tails and exert integrin-specific activation effects

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5156318

29 May 2018

Interactions of platelet integrin alphaIIb and beta3 transmembrane domains in mammalian cell membranes and their role in integrin activation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5156318

29 May 2018

Prediction of membrane protein structures with complex topologies using limited constraints

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5156318

29 May 2018

Structure of a Complete Integrin Ectodomain in a Physiologic Resting State and Activation and Deactivation by Applied Forces

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5156318

29 May 2018

The GPIIb/IIIa (integrin alphaIIbbeta3) odyssey: a technology-driven saga of a receptor with twists, turns, and even a bend

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5156318

29 May 2018

Structure of the Integrin IIb Transmembrane Segment

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5156318

29 May 2018

Structure of the integrin beta3 transmembrane segment in phospholipid bicelles and detergent micelles

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5156318

29 May 2018

Kindlin-3 is essential for integrin activation and platelet aggregation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5156318

29 May 2018

Toward high-resolution prediction and design of transmembrane helical protein structures

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5156318

29 May 2018

Requirement of alpha and beta subunit transmembrane helix separation for integrin outside-in signaling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5156318

29 May 2018

Structural basis of integrin regulation and signaling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5156318

29 May 2018

Disrupting integrin transmembrane domain heterodimerization increases ligand binding affinity, not valency or clustering.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5156318

29 May 2018

A push-pull mechanism for regulating integrin function

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5156318

29 May 2018

A specific interface between integrin transmembrane helices and affinity for ligand

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5156318

29 May 2018

Extending the treatment of backbone energetics in protein force fields: limitations of gas-phase quantum mechanics in reproducing protein conformational distributions in molecular dynamics simulations

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5156318

29 May 2018

Determination of N- and C-terminal borders of the transmembrane domain of integrin subunits

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5156318

29 May 2018

Integrins: bidirectional, allosteric signaling machines

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5156318

29 May 2018

A structural mechanism of integrin alpha(IIb)beta(3) "inside-out" activation as regulated by its cytoplasmic face

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5156318

29 May 2018

The phosphotyrosine binding-like domain of talin activates integrins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5156318

29 May 2018

Breaking the integrin hinge. A defined structural constraint regulates integrin signaling

1 reference

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29 May 2018

Simulaid: a simulation facilitator and analysis program

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17 August 2018

Computational design of peptides that target transmembrane helices.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5156318

17 August 2018

TRAJELIX: a computational tool for the geometric characterization of protein helices during molecular dynamics simulations.

1 reference

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17 August 2018

Transmembrane domain helix packing stabilizes integrin alphaIIbbeta3 in the low affinity state

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5156318

17 August 2018

Bidirectional transmembrane signaling by cytoplasmic domain separation in integrins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5156318

17 August 2018

Global conformational rearrangements in integrin extracellular domains in outside-in and inside-out signaling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5156318

17 August 2018

Anton, a special-purpose machine for molecular dynamics simulation

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21 January 2018

Determination of the Border between the Transmembrane and Cytoplasmic Domains of Human Integrin Subunits

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21 January 2018

The inner world of cell adhesion: integrin cytoplasmic domains

1 reference

https://pubmed.ncbi.nlm.nih.gov/24677266

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1002/PROT.24540

1 reference

Europe PubMed Central

16 October 2017

1 reference

Europe PubMed Central

16 October 2017

1 reference

Europe PubMed Central

16 October 2017

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