(Q42125458)

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The GLP-1 Receptor Agonist Liraglutide Improves Memory Function and Increases Hippocampal CA1 Neuronal Numbers in a Senescence-Accelerated Mouse Model of Alzheimer's Disease.

scientific article published on 13 April 2015

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25869785%20AND%20SRC:MED&resulttype=core&format=json

5 March 2020

The GLP-1 Receptor Agonist Liraglutide Improves Memory Function and Increases Hippocampal CA1 Neuronal Numbers in a Senescence-Accelerated Mouse Model of Alzheimer's Disease (English)

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5 March 2020

Alzheimer's disease

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Henrik H Hansen

1

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5 March 2020

Katrine Fabricius

2

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5 March 2020

Pernille Barkholt

3

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5 March 2020

Michael L Niehoff

4

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5 March 2020

Jacob Jelsing

6

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5 March 2020

Charles Pyke

7

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5 March 2020

Susan A Farr

9

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5 March 2020

Niels Vrang

10

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5 March 2020

publication date

1 January 2015

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5 March 2020

Journal of Alzheimer's Disease

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5 March 2020

46

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5 March 2020

4

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5 March 2020

877-888

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5 March 2020

GLP-1 improves neuropathology after murine cold lesion brain trauma

1 reference

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29 May 2018

Expression and distribution of glucagon-like peptide-1 receptor mRNA, protein and binding in the male nonhuman primate (Macaca mulatta) brain.

1 reference

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29 May 2018

The arcuate nucleus mediates GLP-1 receptor agonist liraglutide-dependent weight loss

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4878312

29 May 2018

Hippocampal GLP-1 receptors influence food intake, meal size, and effort-based responding for food through volume transmission

1 reference

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29 May 2018

Selective alterations of neurons and circuits related to early memory loss in Alzheimer's disease.

1 reference

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29 May 2018

Differences in acute anorectic effects of long-acting GLP-1 receptor agonists in rats.

1 reference

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29 May 2018

Neuronal GLP1R mediates liraglutide's anorectic but not glucose-lowering effect

1 reference

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29 May 2018

At the centennial of Michaelis and Menten, competing Michaelis-Menten steps explain effect of GLP-1 on blood-brain transfer and metabolism of glucose

1 reference

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29 May 2018

Alzheimer disease: epidemiology, diagnostic criteria, risk factors and biomarkers

1 reference

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29 May 2018

Liraglutide can reverse memory impairment, synaptic loss and reduce plaque load in aged APP/PS1 mice, a model of Alzheimer's disease.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4878312

29 May 2018

SAMP8 mice have altered hippocampal gene expression in long term potentiation, phosphatidylinositol signaling, and endocytosis pathways

1 reference

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29 May 2018

Exenatide promotes cognitive enhancement and positive brain metabolic changes in PS1-KI mice but has no effects in 3xTg-AD animals.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4878312

29 May 2018

Chronic treatment with the GLP1 analogue liraglutide increases cell proliferation and differentiation into neurons in an AD mouse model

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4878312

29 May 2018

The diabetes drug liraglutide ameliorates aberrant insulin receptor localisation and signalling in parallel with decreasing both amyloid-β plaque and glial pathology in a mouse model of Alzheimer's disease.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4878312

29 May 2018

Demonstrated brain insulin resistance in Alzheimer's disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive decline

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4878312

29 May 2018

An anti-diabetes agent protects the mouse brain from defective insulin signaling caused by Alzheimer's disease- associated Aβ oligomers

1 reference

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29 May 2018

The SAMP8 mouse: a model to develop therapeutic interventions for Alzheimer's disease

1 reference

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29 May 2018

Neuropathological alterations in Alzheimer disease

1 reference

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29 May 2018

The role of nausea in food intake and body weight suppression by peripheral GLP-1 receptor agonists, exendin-4 and liraglutide

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4878312

29 May 2018

Intranasal insulin therapy for Alzheimer disease and amnestic mild cognitive impairment: a pilot clinical trial

1 reference

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29 May 2018

Metallothionein 3 attenuated the apoptosis of neurons in the CA1 region of the hippocampus in the senescence-accelerated mouse/PRONE8 (SAMP8)

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4878312

29 May 2018

Administration of amyloid-β42 oligomer-specific monoclonal antibody improved memory performance in SAMP8 mice

1 reference

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29 May 2018

Insulin metabolism and the risk of Alzheimer disease: the Rotterdam Study

1 reference

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29 May 2018

Analysis of neuronal nitric oxide synthase expression and increasing astrogliosis in the brain of senescence-accelerated-prone 8 mice.

1 reference

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29 May 2018

Enhancing the GLP-1 receptor signaling pathway leads to proliferation and neuroprotection in human neuroblastoma cells

1 reference

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29 May 2018

Alzheimer's Disease

1 reference

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29 May 2018

One-trial object recognition in rats and mice: methodological and theoretical issues.

1 reference

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29 May 2018

Epidemiology of Alzheimer's disease: occurrence, determinants, and strategies toward intervention

1 reference

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29 May 2018

From aging to Alzheimer's disease: unveiling "the switch" with the senescence-accelerated mouse model (SAMP8).

1 reference

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29 May 2018

New roles for insulin-like hormones in neuronal signalling and protection: new hopes for novel treatments of Alzheimer's disease?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4878312

29 May 2018

Defects in IGF-1 receptor, insulin receptor and IRS-1/2 in Alzheimer's disease indicate possible resistance to IGF-1 and insulin signalling

1 reference

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29 May 2018

Estimators of the precision of stereological estimates: an example based on the CA1 pyramidal cell layer of rats

1 reference

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29 May 2018

Impaired insulin and insulin-like growth factor expression and signaling mechanisms in Alzheimer's disease--is this type 3 diabetes?

1 reference

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29 May 2018

An overview of the tasks used to test working memory in rodents

1 reference

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29 May 2018

Distribution of pre-pro-glucagon and glucagon-like peptide-1 receptor messenger RNAs in the rat central nervous system

1 reference

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29 May 2018

A new continuous alternation task in T-maze detects hippocampal dysfunction in mice. A strain comparison and lesion study

1 reference

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29 May 2018

Relationship of impaired brain glucose metabolism to learning deficit in the senescence-accelerated mouse

1 reference

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29 May 2018

Neuroanatomy of memory

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29 May 2018

Unbiased stereological estimation of the total number of neurons in the subdivisions of the rat hippocampus using the optical fractionator

1 reference

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29 May 2018

Early onset of age-related impairment of aversive and appetitive learning in the SAM-P/8 mouse

1 reference

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29 May 2018

Neuroprotective and anti-apoptotic effects of liraglutide in the rat brain following focal cerebral ischemia

1 reference

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17 August 2018

Lixisenatide, a drug developed to treat type 2 diabetes, shows neuroprotective effects in a mouse model of Alzheimer's disease

1 reference

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17 August 2018

Long-term metabolic benefits of exenatide in mice are mediated solely via the known glucagon-like peptide 1 receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4878312

17 August 2018

The neuroprotection of liraglutide on Alzheimer-like learning and memory impairment by modulating the hyperphosphorylation of tau and neurofilament proteins and insulin signaling pathways in mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4878312

17 August 2018

Age-related alteration in cerebral blood flow and energy failure is correlated with cognitive impairment in the senescence-accelerated prone mouse strain 8 (SAMP8).

1 reference

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17 August 2018

Effects of liraglutide on neurodegeneration, blood flow and cognition in Alzheimer´s disease - protocol for a controlled, randomized double-blinded trial

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4878312

17 August 2018

Hippocampal neuron loss is correlated with cognitive deficits in SAMP8 mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4878312

17 August 2018

Liraglutide protects against amyloid-β protein-induced impairment of spatial learning and memory in rats

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4878312

17 August 2018

The diabetes drug liraglutide prevents degenerative processes in a mouse model of Alzheimer's disease.

1 reference

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17 August 2018

Cerebral amyloid angiopathy, blood-brain barrier disruption and amyloid accumulation in SAMP8 mice.

1 reference

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17 August 2018

Early amyloid accumulation in the hippocampus of SAMP8 mice

1 reference

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17 August 2018

Impaired insulin secretion increases the risk of Alzheimer disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4878312

17 August 2018

The expression of GLP-1 receptor mRNA and protein allows the effect of GLP-1 on glucose metabolism in the human hypothalamus and brainstem

1 reference

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17 August 2018

On the delay-dependent involvement of the hippocampus in object recognition memory

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17 August 2018

Glucagon-like peptide-1 decreases endogenous amyloid-beta peptide (Abeta) levels and protects hippocampal neurons from death induced by Abeta and iron.

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17 August 2018

Antibody to amyloid beta protein alleviates impaired acquisition, retention, and memory processing in SAMP8 mice

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17 August 2018

Beta-amyloid precursor polypeptide in SAMP8 mice affects learning and memory

1 reference

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17 August 2018

Permanent and temporary inactivation of the hippocampus impairs T-maze footshock avoidance acquisition and retention.

1 reference

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17 August 2018

Age-related changes in septal serotonergic, GABAergic and glutamatergic facilitation of retention in SAMP8 mice.

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17 August 2018

Age-related changes in hippocampal drug facilitation of memory processing in SAMP8 mice.

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17 August 2018

Glucagon-like peptide I receptors in the subfornical organ and the area postrema are accessible to circulating glucagon-like peptide I

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1 December 2018

Identifiers

10.3233/JAD-143090

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Europe PubMed Central

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5 March 2020

PMC publication ID

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Europe PubMed Central

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5 March 2020

PubMed publication ID

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5 March 2020

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