(Q42715682)

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The diabetes drug liraglutide ameliorates aberrant insulin receptor localisation and signalling in parallel with decreasing both amyloid-β plaque and glial pathology in a mouse model of Alzheimer's disease.

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scholarly article

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23011726%20AND%20SRC:MED&resulttype=core&format=json

9 March 2020

The diabetes drug liraglutide ameliorates aberrant insulin receptor localisation and signalling in parallel with decreasing both amyloid-β plaque and glial pathology in a mouse model of Alzheimer's disease (English)

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23011726%20AND%20SRC:MED&resulttype=core&format=json

9 March 2020

Alzheimer's disease

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1 reference

based on heuristic

inferred from title

Christian Hölscher

6

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23011726%20AND%20SRC:MED&resulttype=core&format=json

9 March 2020

Meghan Coakley McCarthy

4

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23011726%20AND%20SRC:MED&resulttype=core&format=json

9 March 2020

7

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23011726%20AND%20SRC:MED&resulttype=core&format=json

9 March 2020

author name string

Caitriona M Long-Smith

1

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23011726%20AND%20SRC:MED&resulttype=core&format=json

9 March 2020

Sean Manning

2

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23011726%20AND%20SRC:MED&resulttype=core&format=json

9 March 2020

Paula L McClean

3

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23011726%20AND%20SRC:MED&resulttype=core&format=json

9 March 2020

Domhnall J O'Halloran

5

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23011726%20AND%20SRC:MED&resulttype=core&format=json

9 March 2020

publication date

21 September 2012

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23011726%20AND%20SRC:MED&resulttype=core&format=json

9 March 2020

NeuroMolecular Medicine

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23011726%20AND%20SRC:MED&resulttype=core&format=json

9 March 2020

15

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23011726%20AND%20SRC:MED&resulttype=core&format=json

9 March 2020

1

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23011726%20AND%20SRC:MED&resulttype=core&format=json

9 March 2020

102-114

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23011726%20AND%20SRC:MED&resulttype=core&format=json

9 March 2020

https://scigraph.springernature.com/pub.10.1007/s12017-012-8199-5

0 references

Impairment of synaptic plasticity and memory formation in GLP-1 receptor KO mice: Interaction between type 2 diabetes and Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1007%2FS12017-012-8199-5

21 January 2018

The potential of anti-inflammatory drugs for the treatment of Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1007%2FS12017-012-8199-5

21 January 2018

Inflammation and Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1007%2FS12017-012-8199-5

21 January 2018

Up-regulation of phosphorylated/activated p70 S6 kinase and its relationship to neurofibrillary pathology in Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1007%2FS12017-012-8199-5

21 January 2018

Biology of incretins: GLP-1 and GIP

1 reference

https://api.crossref.org/works/10.1007%2FS12017-012-8199-5

21 January 2018

The PI3K-Akt-mTOR pathway regulates Abeta oligomer induced neuronal cell cycle events

1 reference

https://api.crossref.org/works/10.1007%2FS12017-012-8199-5

21 January 2018

An anti-diabetes agent protects the mouse brain from defective insulin signaling caused by Alzheimer's disease- associated Aβ oligomers

1 reference

https://api.crossref.org/works/10.1007%2FS12017-012-8199-5

21 January 2018

Molecular interplay between mammalian target of rapamycin (mTOR), amyloid-beta, and Tau: effects on cognitive impairments

1 reference

https://api.crossref.org/works/10.1007%2FS12017-012-8199-5

21 January 2018

CBP gene transfer increases BDNF levels and ameliorates learning and memory deficits in a mouse model of Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1007%2FS12017-012-8199-5

21 January 2018

Naturally secreted amyloid-beta increases mammalian target of rapamycin (mTOR) activity via a PRAS40-mediated mechanism

1 reference

https://api.crossref.org/works/10.1007%2FS12017-012-8199-5

21 January 2018

Type 2 diabetes mellitus, dyslipidemia, and Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1007%2FS12017-012-8199-5

21 January 2018

Insulin resistance syndrome and Alzheimer's disease: age- and obesity-related effects on memory, amyloid, and inflammation

1 reference

https://api.crossref.org/works/10.1007%2FS12017-012-8199-5

21 January 2018

Insulin resistance and Alzheimer's disease pathogenesis: potential mechanisms and implications for treatment

1 reference

https://api.crossref.org/works/10.1007%2FS12017-012-8199-5

21 January 2018

Long-term inhibition of dipeptidyl peptidase-4 in Alzheimer's prone mice.

1 reference

https://api.crossref.org/works/10.1007%2FS12017-012-8199-5

21 January 2018

Protection of synapses against Alzheimer's-linked toxins: insulin signaling prevents the pathogenic binding of Abeta oligomers

1 reference

https://api.crossref.org/works/10.1007%2FS12017-012-8199-5

21 January 2018

Alzheimer's disease is type 3 diabetes-evidence reviewed

1 reference

https://api.crossref.org/works/10.1007%2FS12017-012-8199-5

21 January 2018

The incretin system: glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors in type 2 diabetes

1 reference

https://api.crossref.org/works/10.1007%2FS12017-012-8199-5

21 January 2018

Glucagon-like peptide-1 receptor is involved in learning and neuroprotection

1 reference

https://api.crossref.org/works/10.1007%2FS12017-012-8199-5

21 January 2018

The Aβ oligomer hypothesis for synapse failure and memory loss in Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1007%2FS12017-012-8199-5

21 January 2018

Plaque-derived oxidative stress mediates distorted neurite trajectories in the Alzheimer mouse model.

1 reference

https://api.crossref.org/works/10.1007%2FS12017-012-8199-5

21 January 2018

Synaptic plasticity in the hippocampus of a APP/PS1 mouse model of Alzheimer's disease is impaired in old but not young mice

1 reference

https://api.crossref.org/works/10.1007%2FS12017-012-8199-5

21 January 2018

Val(8)GLP-1 rescues synaptic plasticity and reduces dense core plaques in APP/PS1 mice

1 reference

https://api.crossref.org/works/10.1007%2FS12017-012-8199-5

21 January 2018

Time course of the development of Alzheimer-like pathology in the doubly transgenic PS1+APP mouse

1 reference

https://api.crossref.org/works/10.1007%2FS12017-012-8199-5

21 January 2018

Neurodegeneration and neurogenesis: focus on Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1007%2FS12017-012-8199-5

21 January 2018

Activation of Akt/PKB, increased phosphorylation of Akt substrates and loss and altered distribution of Akt and PTEN are features of Alzheimer's disease pathology

1 reference

https://api.crossref.org/works/10.1007%2FS12017-012-8199-5

21 January 2018

Receptors for the incretin glucagon-like peptide-1 are expressed on neurons in the central nervous system.

1 reference

https://api.crossref.org/works/10.1007%2FS12017-012-8199-5

21 January 2018

Diabetes as a risk factor for Alzheimer's disease: insulin signalling impairment in the brain as an alternative model of Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1007%2FS12017-012-8199-5

21 January 2018

New roles for insulin-like hormones in neuronal signalling and protection: new hopes for novel treatments of Alzheimer's disease?

1 reference

https://api.crossref.org/works/10.1007%2FS12017-012-8199-5

21 January 2018

The Physiology of Glucagon-like Peptide 1

1 reference

https://api.crossref.org/works/10.1007%2FS12017-012-8199-5

21 January 2018

Is sporadic Alzheimer disease the brain type of non-insulin dependent diabetes mellitus? A challenging hypothesis.

1 reference

https://api.crossref.org/works/10.1007%2FS12017-012-8199-5

21 January 2018

Glucose metabolism and insulin receptor signal transduction in Alzheimer disease

1 reference

https://api.crossref.org/works/10.1007%2FS12017-012-8199-5

21 January 2018

Glucagon-like peptide-1 inhibits LPS-induced IL-1beta production in cultured rat astrocytes.

1 reference

https://api.crossref.org/works/10.1007%2FS12017-012-8199-5

21 January 2018

APP processing and amyloid deposition in mice haplo-insufficient for presenilin 1.

1 reference

https://api.crossref.org/works/10.1007%2FS12017-012-8199-5

21 January 2018

Co-expression of multiple transgenes in mouse CNS: a comparison of strategies.

1 reference

https://api.crossref.org/works/10.1007%2FS12017-012-8199-5

21 January 2018

Exendin-4 protects dopaminergic neurons by inhibition of microglial activation and matrix metalloproteinase-3 expression in an animal model of Parkinson's disease

1 reference

https://api.crossref.org/works/10.1007%2FS12017-012-8199-5

21 January 2018

Encapsulated native and glucagon-like peptide-1 transfected human mesenchymal stem cells in a transgenic mouse model of Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1007%2FS12017-012-8199-5

21 January 2018

Ischemia-induced changes in glucagon-like peptide-1 receptor and neuroprotective effect of its agonist, exendin-4, in experimental transient cerebral ischemia.

1 reference

https://api.crossref.org/works/10.1007%2FS12017-012-8199-5

21 January 2018

GLP-1 receptor stimulation reduces amyloid-beta peptide accumulation and cytotoxicity in cellular and animal models of Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1007%2FS12017-012-8199-5

21 January 2018

GLP-1 receptor stimulation preserves primary cortical and dopaminergic neurons in cellular and rodent models of stroke and Parkinsonism

1 reference

https://api.crossref.org/works/10.1007%2FS12017-012-8199-5

21 January 2018

Incretin-based therapies for type 2 diabetes mellitus

1 reference

https://api.crossref.org/works/10.1007%2FS12017-012-8199-5

21 January 2018

Adiposity, type 2 diabetes, and Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1007%2FS12017-012-8199-5

21 January 2018

Beta-amyloid oligomers induce phosphorylation of tau and inactivation of insulin receptor substrate via c-Jun N-terminal kinase signaling: suppression by omega-3 fatty acids and curcumin.

1 reference

https://api.crossref.org/works/10.1007%2FS12017-012-8199-5

21 January 2018

The diabetes drug liraglutide prevents degenerative processes in a mouse model of Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1007%2FS12017-012-8199-5

21 January 2018

Distribution of pre-pro-glucagon and glucagon-like peptide-1 receptor messenger RNAs in the rat central nervous system.

1 reference

https://api.crossref.org/works/10.1007%2FS12017-012-8199-5

21 January 2018

Defects in IGF-1 receptor, insulin receptor and IRS-1/2 in Alzheimer's disease indicate possible resistance to IGF-1 and insulin signalling

1 reference

https://api.crossref.org/works/10.1007%2FS12017-012-8199-5

21 January 2018

Endogenous GLP-1 modulates hippocampal activity in beta-amyloid protein-treated rats.

1 reference

https://api.crossref.org/works/10.1007%2FS12017-012-8199-5

21 January 2018

Endogenous GLP-1 is involved in beta-amyloid protein-induced memory impairment and hippocampal neuronal death in rats.

1 reference

https://api.crossref.org/works/10.1007%2FS12017-012-8199-5

21 January 2018

Insulin and IGF-1 signalling: longevity, protein homoeostasis and Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1007%2FS12017-012-8199-5

21 January 2018

The glucagon-like peptides: a double-edged therapeutic sword?

1 reference

https://api.crossref.org/works/10.1007%2FS12017-012-8199-5

21 January 2018

Protection and reversal of excitotoxic neuronal damage by glucagon-like peptide-1 and exendin-4.

1 reference

https://api.crossref.org/works/10.1007%2FS12017-012-8199-5

21 January 2018

Evidence of GLP-1-mediated neuroprotection in an animal model of pyridoxine-induced peripheral sensory neuropathy

1 reference

https://api.crossref.org/works/10.1007%2FS12017-012-8199-5

21 January 2018

Glucagon-like peptide-1 decreases endogenous amyloid-beta peptide (Abeta) levels and protects hippocampal neurons from death induced by Abeta and iron.

1 reference

https://api.crossref.org/works/10.1007%2FS12017-012-8199-5

21 January 2018

Downregulation of CREB expression in Alzheimer's brain and in Aβ-treated rat hippocampal neurons

1 reference

https://api.crossref.org/works/10.1007%2FS12017-012-8199-5

21 January 2018

Diabetes type II: a risk factor for depression-Parkinson-Alzheimer?

1 reference

https://api.crossref.org/works/10.1007%2FS12017-012-8199-5

21 January 2018

Glucose metabolism and the risk of Alzheimer's disease and dementia: a population-based 12 year follow-up study in 71-year-old men.

1 reference

https://api.crossref.org/works/10.1007%2FS12017-012-8199-5

21 January 2018

Amyloid deposition and inflammation in APPswe/PS1dE9 mouse model of Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1007%2FS12017-012-8199-5

21 January 2018

Impaired insulin and insulin-like growth factor expression and signaling mechanisms in Alzheimer's disease – is this type 3 diabetes?

1 reference

https://api.crossref.org/works/10.1007%2FS12017-012-8199-5

21 January 2018

Demonstrated brain insulin resistance in Alzheimer's disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive decline

1 reference

https://api.crossref.org/works/10.1007%2FS12017-012-8199-5

21 January 2018

Soluble Abeta inhibits specific signal transduction cascades common to the insulin receptor pathway.

1 reference

https://api.crossref.org/works/10.1007%2FS12017-012-8199-5

21 January 2018

mTOR links incretin signaling to HIF induction in pancreatic beta cells

1 reference

https://api.crossref.org/works/10.1007%2FS12017-012-8199-5

21 January 2018

Amyloid beta -peptide inhibition of the PKA/CREB pathway and long-term potentiation: reversibility by drugs that enhance cAMP signaling

1 reference

https://api.crossref.org/works/10.1007%2FS12017-012-8199-5

21 January 2018

Amyloid beta induces the morphological neurodegenerative triad of spine loss, dendritic simplification, and neuritic dystrophies through calcineurin activation

1 reference

https://api.crossref.org/works/10.1007%2FS12017-012-8199-5

21 January 2018

Insulin receptor dysfunction impairs cellular clearance of neurotoxic oligomeric a{beta}

1 reference

https://api.crossref.org/works/10.1007%2FS12017-012-8199-5

21 January 2018

Amyloid beta oligomers induce impairment of neuronal insulin receptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/23011726

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Multiple inflammatory pathways are involved in the development and progression of cognitive deficits in APPswe/PS1dE9 mice.

1 reference

https://pubmed.ncbi.nlm.nih.gov/23011726

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inflammation, anti-inflammatory agents and Alzheimer disease: the last 12 years

1 reference

https://pubmed.ncbi.nlm.nih.gov/23011726

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Impaired insulin and insulin-like growth factor expression and signaling mechanisms in Alzheimer's disease--is this type 3 diabetes?

1 reference

https://pubmed.ncbi.nlm.nih.gov/23011726

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Distribution of GLP-1 binding sites in the rat brain: evidence that exendin-4 is a ligand of brain GLP-1 binding sites

1 reference

https://pubmed.ncbi.nlm.nih.gov/23011726

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

p70 S6 kinase and tau in Alzheimer's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/23011726

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Review of insulin and insulin-like growth factor expression, signaling, and malfunction in the central nervous system: relevance to Alzheimer's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/23011726

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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