(Q24595310)

2

0 references

Smita Majumder

3

0 references

David X Medina

4

0 references

Walter Holbein

5

0 references

Andrea Magrí

6

0 references

Salvatore Oddo

Journal of Biological Chemistry

7

0 references

language of work or name

English

0 references

publication date

18 March 2011

0 references

published in

0 references

volume

286

0 references

issue

11

0 references

page(s)

8924-32

0 references

describes a project that uses

ImageJ

1 reference

Europe PubMed Central

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3058958/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

cites work

Amyloid-beta-induced neuronal dysfunction in Alzheimer's disease: from synapses toward neural networks

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Inhibition of mTOR by rapamycin abolishes cognitive deficits and reduces amyloid-beta levels in a mouse model of Alzheimer's disease

24 March 2017

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Molecular interplay between mammalian target of rapamycin (mTOR), amyloid-beta, and Tau: effects on cognitive impairments

24 March 2017

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Rapamycin rescues TDP-43 mislocalization and the associated low molecular mass neurofilament instability

24 March 2017

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Rapamycin fed late in life extends lifespan in genetically heterogeneous mice

24 March 2017

1 reference

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ULK-Atg13-FIP200 complexes mediate mTOR signaling to the autophagy machinery

24 March 2017

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Reversal of learning deficits in a Tsc2+/- mouse model of tuberous sclerosis

24 March 2017

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PRAS40 is an insulin-regulated inhibitor of the mTORC1 protein kinase

24 March 2017

1 reference

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Extension of chronological life span in yeast by decreased TOR pathway signaling

24 March 2017

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Regulation of lifespan in Drosophila by modulation of genes in the TOR signaling pathway

24 March 2017

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Up-regulation of phosphorylated/activated p70 S6 kinase and its relationship to neurofibrillary pathology in Alzheimer's disease

24 March 2017

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Two TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth control

24 March 2017

1 reference

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mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery

24 March 2017

1 reference

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Amyloid plaque core protein in Alzheimer disease and Down syndrome

24 March 2017

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24 March 2017

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TOR signaling in growth and metabolism

24 March 2017

1 reference

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Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo

24 March 2017

1 reference

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Lysosomal proteolysis and autophagy require presenilin 1 and are disrupted by Alzheimer-related PS1 mutations

24 March 2017

1 reference

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Cannabinoid modulation of hippocampal long-term memory is mediated by mTOR signaling

24 March 2017

1 reference

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PIM1 protein kinase regulates PRAS40 phosphorylation and mTOR activity in FDCP1 cells

24 March 2017

1 reference

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mTOR-dependent signalling in Alzheimer's disease

24 March 2017

1 reference

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The ubiquitin-proteasome system in Alzheimer's disease

24 March 2017

1 reference

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Coupling of mammalian target of rapamycin with phosphoinositide 3-kinase signaling pathway regulates protein phosphatase 2A- and glycogen synthase kinase-3 -dependent phosphorylation of Tau

24 March 2017

1 reference

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Defining the role of mTOR in cancer

24 March 2017

1 reference

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PRAS40 regulates mTORC1 kinase activity by functioning as a direct inhibitor of substrate binding

24 March 2017

1 reference

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Regulation of yeast replicative life span by TOR and Sch9 in response to nutrients

24 March 2017

1 reference

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Upstream and downstream of mTOR

24 March 2017

1 reference

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The TOR pathway interacts with the insulin signaling pathway to regulate C. elegans larval development, metabolism and life span

24 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3058958

Rapamycin-sensitive signalling in long-term consolidation of auditory cortex-dependent memory

24 March 2017

1 reference

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Evidence that production and release of amyloid beta-protein involves the endocytic pathway

24 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3058958

The mammalian target of rapamycin signaling pathway mediates epileptogenesis in a model of temporal lobe epilepsy

24 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3058958

The autophagy-related protein beclin 1 shows reduced expression in early Alzheimer disease and regulates amyloid beta accumulation in mice

24 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3058958

Defects in IGF-1 receptor, insulin receptor and IRS-1/2 in Alzheimer's disease indicate possible resistance to IGF-1 and insulin signalling

24 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3058958

Triple-transgenic model of Alzheimer's disease with plaques and tangles: intracellular Abeta and synaptic dysfunction

24 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3058958

Autophagy as a regulated pathway of cellular degradation

7 April 2017

1 reference

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Alzheimer's disease: Initial report of the purification and characterization of a novel cerebrovascular amyloid protein

7 April 2017

1 reference

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Ribosomal protein S6 kinase 1 signaling regulates mammalian life span

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3058958

An ATP-competitive mammalian target of rapamycin inhibitor reveals rapamycin-resistant functions of mTORC1

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3058958

Natural oligomers of the amyloid-beta protein specifically disrupt cognitive function

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3058958

Genetics: influence of TOR kinase on lifespan in C. elegans

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3058958

Abnormal phosphorylation of the microtubule-associated protein tau (tau) in Alzheimer cytoskeletal pathology

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3058958

Microtubule-associated protein tau (tau) is a major antigenic component of paired helical filaments in Alzheimer disease

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3058958

Phosphorylation of PRAS40 on Thr246 by PKB/AKT facilitates efficient phosphorylation of Ser183 by mTORC1.

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3058958

Rapamycin protects against neuron death in in vitro and in vivo models of Parkinson's disease

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3058958

Reduced IGF-1 signaling delays age-associated proteotoxicity in mice

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3058958

Beta-amyloid oligomers induce phosphorylation of tau and inactivation of insulin receptor substrate via c-Jun N-terminal kinase signaling: suppression by omega-3 fatty acids and curcumin.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3058958

The PI3K-Akt-mTOR pathway regulates Abeta oligomer induced neuronal cell cycle events

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3058958

Not all substrates are treated equally: implications for mTOR, rapamycin-resistance and cancer therapy

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3058958

Rapamycin differentially inhibits S6Ks and 4E-BP1 to mediate cell-type-specific repression of mRNA translation

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3058958

p70 S6 kinase and tau in Alzheimer's disease.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3058958

Genetically altering Abeta distribution from the brain to the vasculature ameliorates tau pathology

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3058958

Autophagy induction and autophagosome clearance in neurons: relationship to autophagic pathology in Alzheimer's disease

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3058958

Binding of rapamycin analogs to calcium channels and FKBP52 contributes to their neuroprotective activities

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3058958

Autophagy and neurodegeneration: when the cleaning crew goes on strike

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3058958

Amyloid-beta peptides induce several chemokine mRNA expressions in the primary microglia and Ra2 cell line via the PI3K/Akt and/or ERK pathway

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3058958

IRS-1: auditing the effectiveness of mTOR inhibitors

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3058958

A dynamic relationship between intracellular and extracellular pools of Abeta

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3058958

The Akt-mTOR tango and its relevance to cancer

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3058958

Amyloid accumulation and pathogensis of Alzheimer's disease: significance of monomeric, oligomeric and fibrillar Abeta.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3058958

Dysregulation of the TSC-mTOR pathway in human disease

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3058958

Autophagy: many paths to the same end.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3058958

An RNA-dependent protein kinase is involved in tunicamycin-induced apoptosis and Alzheimer's disease

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3058958

Abeta toxicity in Alzheimer's disease: globular oligomers (ADDLs) as new vaccine and drug targets

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3058958

A transient, neuron-wide form of CREB-mediated long-term facilitation can be stabilized at specific synapses by local protein synthesis.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3058958

Excess protein synthesis in Drosophila fragile X mutants impairs long-term memory

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3058958

Raptor-rictor axis in TGFbeta-induced protein synthesis.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3058958

Phosphorylated tau protein is integrated into paired helical filaments in Alzheimer's disease.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3058958

Detection and staging of dementia in Alzheimer's disease. Use of the neuropsychological measures developed for the Consortium to Establish a Registry for Alzheimer's Disease

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3058958

Induction of matrix metalloproteinases (MMP3, MMP12 and MMP13) expression in the microglia by amyloid-beta stimulation via the PI3K/Akt pathway.

30 May 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.180638

Effect of the Alzheimer amyloid fragment Abeta(25-35) on Akt/PKB kinase and survival of PC12 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.180638

Activation of Akt/PKB, increased phosphorylation of Akt substrates and loss and altered distribution of Akt and PTEN are features of Alzheimer's disease pathology

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.180638

mTOR signaling in epileptogenesis: too much of a good thing?

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.180638

Blocking Abeta42 accumulation delays the onset and progression of tau pathology via the C terminus of heat shock protein70-interacting protein: a mechanistic link between Abeta and tau pathology.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.180638

Genetically augmenting tau levels does not modulate the onset or progression of Abeta pathology in transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.180638

Abeta immunotherapy leads to clearance of early, but not late, hyperphosphorylated tau aggregates via the proteasome

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.180638

Phosphorylation of eukaryotic initiation factor-2alpha (eIF2alpha) is associated with neuronal degeneration in Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.180638

Activation of the cell stress kinase PKR in Alzheimer's disease and human amyloid precursor protein transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.180638

Temporal profile of amyloid-beta (Abeta) oligomerization in an in vivo model of Alzheimer disease. A link between Abeta and tau pathology

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.180638

Aggregation of secreted amyloid beta-protein into sodium dodecyl sulfate-stable oligomers in cell culture

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.180638

Reduction of soluble Abeta and tau, but not soluble Abeta alone, ameliorates cognitive decline in transgenic mice with plaques and tangles

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.180638

TOR-mediated cell-cycle activation causes neurodegeneration in a Drosophila tauopathy model.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.180638

Rapamycin inhibits mTORC1, but not completely.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.180638

Intracranially Administered Anti-Αβ Antibodies Reduce β-Amyloid Deposition by Mechanisms Both Independent of and Associated with Microglial Activation

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3058958

Amyloid beta oligomers induce impairment of neuronal insulin receptors

28 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21266573

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1074/JBC.M110.180638

1 reference

93651

93651

1 reference

1 reference

1 reference