(Q46081295)

English

Blocking Abeta42 accumulation delays the onset and progression of tau pathology via the C terminus of heat shock protein70-interacting protein: a mechanistic link between Abeta and tau pathology.

scientific article published in November 2008

In more languages

Statements

scholarly article

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19020010%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

Blocking Abeta42 accumulation delays the onset and progression of tau pathology via the C terminus of heat shock protein70-interacting protein: a mechanistic link between Abeta and tau pathology (English)

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19020010%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

0 references

author name string

Salvatore Oddo

1

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19020010%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

Antonella Caccamo

2

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19020010%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

Bert Tseng

3

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19020010%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

David Cheng

4

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19020010%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

Vitaly Vasilevko

5

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19020010%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

David H Cribbs

6

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19020010%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

Frank M LaFerla

7

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19020010%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

language of work or name

0 references

publication date

1 November 2008

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19020010%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

Journal of Neuroscience

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19020010%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

28

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19020010%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

47

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19020010%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

12163-12175

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19020010%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

Immunization with amyloid-beta attenuates Alzheimer-disease-like pathology in the PDAPP mouse

1 reference

https://pubmed.ncbi.nlm.nih.gov/19020010

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The impact of different presenilin 1 andpresenilin 2 mutations on amyloid deposition, neurofibrillary changes and neuronal loss in the familial Alzheimer's disease brain: evidence for other phenotype-modifying factors.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19020010

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Impaired proteasome function in Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/19020010

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A beta peptide immunization reduces behavioural impairment and plaques in a model of Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/19020010

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A beta peptide vaccination prevents memory loss in an animal model of Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/19020010

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alzheimer's disease: genes, proteins, and therapy

1 reference

https://pubmed.ncbi.nlm.nih.gov/19020010

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Enhanced neurofibrillary degeneration in transgenic mice expressing mutant tau and APP.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19020010

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Formation of neurofibrillary tangles in P301l tau transgenic mice induced by Abeta 42 fibrils

1 reference

https://pubmed.ncbi.nlm.nih.gov/19020010

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Increased tau phosphorylation but absence of formation of neurofibrillary tangles in mice double transgenic for human tau and Alzheimer mutant (M146L) presenilin-1.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19020010

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics

1 reference

https://pubmed.ncbi.nlm.nih.gov/19020010

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Adjuvant-dependent modulation of Th1 and Th2 responses to immunization with beta-amyloid

1 reference

https://pubmed.ncbi.nlm.nih.gov/19020010

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of Aging and Age-Related Disease by DAF-16 and Heat-Shock Factor

1 reference

https://pubmed.ncbi.nlm.nih.gov/19020010

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dieldrin induces apoptosis by promoting caspase-3-dependent proteolytic cleavage of protein kinase Cdelta in dopaminergic cells: relevance to oxidative stress and dopaminergic degeneration

1 reference

https://pubmed.ncbi.nlm.nih.gov/19020010

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Triple-transgenic model of Alzheimer's disease with plaques and tangles: intracellular Abeta and synaptic dysfunction

1 reference

https://pubmed.ncbi.nlm.nih.gov/19020010

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

CHIP activates HSF1 and confers protection against apoptosis and cellular stress

1 reference

https://pubmed.ncbi.nlm.nih.gov/19020010

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

CHIP-Hsc70 Complex Ubiquitinates Phosphorylated Tau and Enhances Cell Survival

1 reference

https://pubmed.ncbi.nlm.nih.gov/19020010

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Amyloid deposition precedes tangle formation in a triple transgenic model of Alzheimer's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19020010

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

CHIP and Hsp70 regulate tau ubiquitination, degradation and aggregation

1 reference

https://pubmed.ncbi.nlm.nih.gov/19020010

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

CHIP: a link between the chaperone and proteasome systems

1 reference

https://pubmed.ncbi.nlm.nih.gov/19020010

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Abeta immunotherapy leads to clearance of early, but not late, hyperphosphorylated tau aggregates via the proteasome

1 reference

https://pubmed.ncbi.nlm.nih.gov/19020010

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Natural oligomers of the amyloid-beta protein specifically disrupt cognitive function

1 reference

https://pubmed.ncbi.nlm.nih.gov/19020010

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Chronic nicotine administration exacerbates tau pathology in a transgenic model of Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/19020010

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Family-based association between Alzheimer's disease and variants in UBQLN1

1 reference

https://pubmed.ncbi.nlm.nih.gov/19020010

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Intraneuronal Abeta causes the onset of early Alzheimer's disease-related cognitive deficits in transgenic mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/19020010

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Presenilins mediate phosphatidylinositol 3-kinase/AKT and ERK activation via select signaling receptors. Selectivity of PS2 in platelet-derived growth factor signaling.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19020010

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Abeta42 is essential for parenchymal and vascular amyloid deposition in mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/19020010

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Amyloid peptide attenuates the proteasome activity in neuronal cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/19020010

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Temporal profile of amyloid-beta (Abeta) oligomerization in an in vivo model of Alzheimer disease. A link between Abeta and tau pathology

1 reference

https://pubmed.ncbi.nlm.nih.gov/19020010

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Formation of tau inclusions in knock-in mice with familial Alzheimer disease (FAD) mutation of presenilin 1 (PS1).

1 reference

https://pubmed.ncbi.nlm.nih.gov/19020010

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A specific amyloid-beta protein assembly in the brain impairs memory

1 reference

https://pubmed.ncbi.nlm.nih.gov/19020010

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Beta-amyloid accumulation impairs multivesicular body sorting by inhibiting the ubiquitin-proteasome system.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19020010

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/19020010

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Deletion of the ubiquitin ligase CHIP leads to the accumulation, but not the aggregation, of both endogenous phospho- and caspase-3-cleaved tau species.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19020010

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Reduction of soluble Abeta and tau, but not soluble Abeta alone, ameliorates cognitive decline in transgenic mice with plaques and tangles

1 reference

https://pubmed.ncbi.nlm.nih.gov/19020010

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pathways by which Abeta facilitates tau pathology

1 reference

https://pubmed.ncbi.nlm.nih.gov/19020010

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Abeta40 inhibits amyloid deposition in vivo.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19020010

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The high-affinity HSP90-CHIP complex recognizes and selectively degrades phosphorylated tau client proteins

1 reference

https://pubmed.ncbi.nlm.nih.gov/19020010

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Genetically augmenting tau levels does not modulate the onset or progression of Abeta pathology in transgenic mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/19020010

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Reducing endogenous tau ameliorates amyloid beta-induced deficits in an Alzheimer's disease mouse model

1 reference

https://pubmed.ncbi.nlm.nih.gov/19020010

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Abeta inhibits the proteasome and enhances amyloid and tau accumulation

1 reference

https://pubmed.ncbi.nlm.nih.gov/19020010

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tau-mediated neurodegeneration in Alzheimer's disease and related disorders

1 reference

https://pubmed.ncbi.nlm.nih.gov/19020010

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Induction of tau pathology by intracerebral infusion of amyloid-beta -containing brain extract and by amyloid-beta deposition in APP x Tau transgenic mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/19020010

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Early-onset Alzheimer's disease caused by mutations at codon 717 of the beta-amyloid precursor protein gene

1 reference

https://pubmed.ncbi.nlm.nih.gov/19020010

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Microtubule-associated protein tau (tau) is a major antigenic component of paired helical filaments in Alzheimer disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/19020010

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phosphorylated tau protein is integrated into paired helical filaments in Alzheimer's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19020010

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Abnormal phosphorylation of the microtubule-associated protein tau (tau) in Alzheimer cytoskeletal pathology

1 reference

https://pubmed.ncbi.nlm.nih.gov/19020010

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cloning and sequencing of the cDNA encoding a core protein of the paired helical filament of Alzheimer disease: identification as the microtubule-associated protein tau

1 reference

https://pubmed.ncbi.nlm.nih.gov/19020010

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Amyloid plaque core protein in Alzheimer disease and Down syndrome

1 reference

https://pubmed.ncbi.nlm.nih.gov/19020010

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alzheimer's disease: Initial report of the purification and characterization of a novel cerebrovascular amyloid protein

1 reference

https://pubmed.ncbi.nlm.nih.gov/19020010

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/19020010

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Amyloid beta-protein inhibits ubiquitin-dependent protein degradation in vitro

1 reference

https://pubmed.ncbi.nlm.nih.gov/19020010

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The C-terminus of the beta protein is critical in amyloidogenesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/19020010

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Amyloid, the presenilins and Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/19020010

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Increased vulnerability of hippocampal neurons to excitotoxic necrosis in presenilin-1 mutant knock-in mice.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19020010

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1523/JNEUROSCI.2464-08.2008

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19020010%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

release_mzx54ieenbgp3jz6zz3hpw4hxy

1 reference

https://api.fatcat.wiki/v0/release/mzx54ieenbgp3jz6zz3hpw4hxy

24 November 2022

based on heuristic

mapped directly with Wikidata item

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19020010%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19020010%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

Retrieved from "https://www.wikidata.org/w/index.php?title=Q46081295&oldid=1839980142"