(Q42128115)

17 October 2017

Modulating carnitine levels by targeting its biosynthesis pathway - selective inhibition of γ-butyrobetaine hydroxylase (English)

1 reference

17 October 2017

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26682037%20AND%20SRC:MED&resulttype=core&format=json

9 June 2020

Christopher J. Schofield

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26682037%20AND%20SRC:MED&resulttype=core&format=json

9 June 2020

Rasheduzzaman Chowdhury

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26682037%20AND%20SRC:MED&resulttype=core&format=json

9 June 2020

Grazyna Kochan

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26682037%20AND%20SRC:MED&resulttype=core&format=json

9 June 2020

Sophie T Williams

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26682037%20AND%20SRC:MED&resulttype=core&format=json

9 June 2020

Akane Kawamura

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26682037%20AND%20SRC:MED&resulttype=core&format=json

9 June 2020

author name string

Michael A McDonough

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26682037%20AND%20SRC:MED&resulttype=core&format=json

9 June 2020

publication date

1 May 2014

1 reference

17 October 2017

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26682037%20AND%20SRC:MED&resulttype=core&format=json

9 June 2020

volume

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26682037%20AND%20SRC:MED&resulttype=core&format=json

9 June 2020

issue

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26682037%20AND%20SRC:MED&resulttype=core&format=json

9 June 2020

page(s)

1765-1771

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26682037%20AND%20SRC:MED&resulttype=core&format=json

5-Carboxy-8-hydroxyquinoline is a Broad Spectrum 2-Oxoglutarate Oxygenase Inhibitor which Causes Iron Translocation.

9 June 2020

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4678601

Structural basis for a class of nanomolar influenza A neuraminidase inhibitors

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4678601

Oncometabolites: linking altered metabolism with cancer

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4678601

Selective small molecule probes for the hypoxia inducible factor (HIF) prolyl hydroxylases

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4678601

Intestinal microbiota metabolism of L-carnitine, a nutrient in red meat, promotes atherosclerosis

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4678601

Role of the jelly-roll fold in substrate binding by 2-oxoglutarate oxygenases

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4678601

Mechanisms of human histone and nucleic acid demethylases

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4678601

γ-Butyrobetaine hydroxylase catalyses a Stevens type rearrangement

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4678601

Development and application of a fluoride-detection-based fluorescence assay for γ-butyrobetaine hydroxylase

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4678601

Plant Growth Regulator Daminozide Is a Selective Inhibitor of Human KDM2/7 Histone Demethylases

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4678601

Linking of 2-oxoglutarate and substrate binding sites enables potent and highly selective inhibition of JmjC histone demethylases

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4678601

A selective inhibitor and probe of the cellular functions of Jumonji C domain-containing histone demethylases

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4678601

Inhibition of 2-oxoglutarate dependent oxygenases

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4678601

Targeting fatty acid and carbohydrate oxidation--a novel therapeutic intervention in the ischemic and failing heart.

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4678601

Structural and mechanistic studies on γ-butyrobetaine hydroxylase

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4678601

Quantitative High-Throughput Screening Identifies 8-Hydroxyquinolines as Cell-Active Histone Demethylase Inhibitors

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4678601

Mildronate exerts acute anticonvulsant and antihypnotic effects

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4678601

Crystal structure of human gamma-butyrobetaine hydroxylase

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4678601

Enzymology of the carnitine biosynthesis pathway.

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4678601

Mildronate, an inhibitor of carnitine biosynthesis, induces an increase in gamma-butyrobetaine contents and cardioprotection in isolated rat heart infarction

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4678601

Cellular oxygen sensing: Crystal structure of hypoxia-inducible factor prolyl hydroxylase (PHD2)

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4678601

Structural studies on 2-oxoglutarate oxygenases and related double-stranded beta-helix fold proteins

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4678601

Mildronate: an antiischemic drug for neurological indications

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4678601

FeII/alpha-ketoglutarate-dependent hydroxylases and related enzymes

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4678601

The role of carnitine in normal and altered fatty acid metabolism

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4678601

Mildronate: cardioprotective action through carnitine-lowering effect

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4678601

Crystal structure of a clavaminate synthase-Fe(II)-2-oxoglutarate-substrate-NO complex: evidence for metal centered rearrangements

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4678601

Carnitine biosynthesis in mammals

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4678601

Structural and mechanistic studies on 2-oxoglutarate-dependent oxygenases and related enzymes

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4678601

Disorders of mitochondrial fatty acyl-CoA beta-oxidation

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4678601

Gamma-butyrobetaine hydroxylase in human kidney

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4678601

Gamma-butyrobetaine hydroxylase: stereochemical course of the hydroxylation reaction.

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4678601

The role of carnitine in intracellular metabolism

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4678601

Inhibition of carnitine acetyltransferase by mildronate, a regulator of energy metabolism

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4678601

Different modes of inhibitor binding to prolyl hydroxylase by combined use of X-ray crystallography and NMR spectroscopy of paramagnetic complexes

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4678601

Mildronate, a regulator of energy metabolism, reduces atherosclerosis in apoE/LDLR-/- mice

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4678601

Cation-pi interactions involving aromatic amino acids

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4678601

gamma-butyrobetaine hydroxylase: primary and secondary tritium kinetic isotope effects.

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4678601

Carnitine biosynthesis in mammals

17 August 2018

1 reference

Crossref

https://api.crossref.org/works/10.1039%2FC4SC00020J

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4SC00020J

Inhibition of .gamma.-butyrobetaine hydroxylase by cyclopropyl-substituted .gamma.-butyrobetaines

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1039%2FC4SC00020J

Mechanism-based inhibition of bacterial .gamma.-butyrobetaine hydroxylase

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1039%2FC4SC00020J

Optimizing cardiac fatty acid and glucose metabolism as an approach to treating heart failure

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/26682037

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Multiple conformations of the acylenzyme formed in the hydrolysis of methicillin by Citrobacter freundii beta-lactamase: a time-resolved FTIR spectroscopic study

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/26682037

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Carnitine metabolism and its regulation in microorganisms and mammals

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/26682037

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1039/C4SC00020J

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26682037%20AND%20SRC:MED&resulttype=core&format=json

9 June 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26682037%20AND%20SRC:MED&resulttype=core&format=json

9 June 2020

PubMed publication ID

26682037

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26682037%20AND%20SRC:MED&resulttype=core&format=json