(Q42137898)

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Design, synthesis, and biological evaluation of hydroquinone derivatives as novel inhibitors of the sarco/endoplasmic reticulum calcium ATPase

scientific article published on 4 August 2009

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

17 October 2017

Design, synthesis, and biological evaluation of hydroquinone derivatives as novel inhibitors of the sarco/endoplasmic reticulum calcium ATPase (English)

1 reference

Europe PubMed Central

PMC publication ID

17 October 2017

endoplasmic reticulum

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author name string

Stefan Paula

1

1 reference

Europe PubMed Central

PMC publication ID

17 October 2017

Josh Abell

2

1 reference

Europe PubMed Central

PMC publication ID

17 October 2017

Joel Deye

3

1 reference

Europe PubMed Central

PMC publication ID

17 October 2017

Christopher Elam

4

1 reference

Europe PubMed Central

PMC publication ID

17 October 2017

Michael Lape

5

1 reference

Europe PubMed Central

PMC publication ID

17 October 2017

Justin Purnell

6

1 reference

Europe PubMed Central

PMC publication ID

17 October 2017

Robert Ratliff

7

1 reference

Europe PubMed Central

PMC publication ID

17 October 2017

Kelly Sebastian

8

1 reference

Europe PubMed Central

PMC publication ID

17 October 2017

Jodie Zultowsky

9

1 reference

Europe PubMed Central

PMC publication ID

17 October 2017

Robert J Kempton

10

1 reference

Europe PubMed Central

PMC publication ID

17 October 2017

language of work or name

0 references

publication date

4 August 2009

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Europe PubMed Central

PMC publication ID

17 October 2017

Bioorganic & Medicinal Chemistry

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Europe PubMed Central

PMC publication ID

17 October 2017

17

1 reference

Europe PubMed Central

PMC publication ID

17 October 2017

18

1 reference

Europe PubMed Central

PMC publication ID

17 October 2017

6613-6619

1 reference

Europe PubMed Central

PMC publication ID

17 October 2017

Cyclopiazonic Acid Is Complexed to a Divalent Metal Ion When Bound to the Sarcoplasmic Reticulum Ca2+-ATPase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2752035

29 May 2018

Structure-based virtual screening for novel inhibitors of the sarco/endoplasmic reticulum calcium ATPase and their experimental evaluation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2752035

29 May 2018

Molecular determinants of sarco/endoplasmic reticulum calcium ATPase inhibition by hydroquinone-based compounds

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2752035

29 May 2018

Design and total synthesis of unnatural analogues of the sub-nanomolar SERCA inhibitor thapsigargin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2752035

29 May 2018

Total synthesis of thapsigargin, a potent SERCA pump inhibitor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2752035

29 May 2018

Natural products as starting materials for development of second-generation SERCA inhibitors targeted towards prostate cancer cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2752035

29 May 2018

The effects of the phenylalanine 256 to valine mutation on the sensitivity of sarcoplasmic/endoplasmic reticulum Ca2+ ATPase (SERCA) Ca2+ pump isoforms 1, 2, and 3 to thapsigargin and other inhibitors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2752035

29 May 2018

New strategies for the medical treatment of prostate cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2752035

29 May 2018

Structural role of countertransport revealed in Ca(2+) pump crystal structure in the absence of Ca(2+)

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2752035

29 May 2018

The SERCA pump as a therapeutic target: making a "smart bomb" for prostate cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2752035

29 May 2018

Synthesis of the thapsigargins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2752035

29 May 2018

Improved protein-ligand docking using GOLD

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2752035

29 May 2018

Mutation to the glutamate in the fourth membrane segment of Na+,K+-ATPase and Ca2+-ATPase affects cation binding from both sides of the membrane and destabilizes the occluded enzyme forms

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2752035

29 May 2018

Development and validation of a genetic algorithm for flexible docking

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2752035

29 May 2018

Structural organization, ion transport, and energy transduction of P-type ATPases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2752035

29 May 2018

LIGPLOT: a program to generate schematic diagrams of protein-ligand interactions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2752035

29 May 2018

Binding of sesquiterpene lactone inhibitors to the Ca(2+)-ATPase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2752035

29 May 2018

Relationship between the inhibition constant (K1) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2752035

29 May 2018

Clotrimazole: a review of its antifungal activity and therapeutic efficacy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2752035

29 May 2018

An improved assay for nanomole amounts of inorganic phosphate

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2752035

29 May 2018

Thapsigargine and thapsigargicine, two new histamine liberators from Thapsia garganica L.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2752035

29 May 2018

Tetrabromobisphenol A (TBBPA), induces cell death in TM4 Sertoli cells by modulating Ca2+ transport proteins and causing dysregulation of Ca2+ homeostasis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2752035

17 August 2018

The widely utilized brominated flame retardant tetrabromobisphenol A (TBBPA) is a potent inhibitor of the SERCA Ca2+ pump

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2752035

17 August 2018

SERCA-inhibiting activity of C-19 terpenolides from Thapsia garganica and their possible biogenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2752035

17 August 2018

Molecular determinants of thapsigargin binding by SERCA Ca2+-ATPase: a computational docking study

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2752035

17 August 2018

Ca2+ occlusion and gating function of Glu309 in the ADP-fluoroaluminate analog of the Ca2+-ATPase phosphoenzyme intermediate

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2752035

17 August 2018

Prostate-specific antigen-activated thapsigargin prodrug as targeted therapy for prostate cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2752035

17 August 2018

Design, synthesis, and pharmacological evaluation of thapsigargin analogues for targeting apoptosis to prostatic cancer cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2752035

17 August 2018

Inhibition of the SERCA Ca2+ pumps by curcumin. Curcumin putatively stabilizes the interaction between the nucleotide-binding and phosphorylation domains in the absence of ATP.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2752035

17 August 2018

A tool coming of age: thapsigargin as an inhibitor of sarco-endoplasmic reticulum Ca(2+)-ATPases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2752035

17 August 2018

Molecular recognition of receptor sites using a genetic algorithm with a description of desolvation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2752035

17 August 2018

The acute toxicity of the mycotoxin cyclopiazonic acid to rats

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2752035

17 August 2018

Cyclopiazonic acid is a specific inhibitor of the Ca2+-ATPase of sarcoplasmic reticulum

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2752035

17 August 2018

Inorganic and organic phosphate measurements in the nanomolar range

1 reference

https://pubmed.ncbi.nlm.nih.gov/19699645

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

2,5-Di(tert-butyl)-1,4-benzohydroquinone--a novel inhibitor of liver microsomal Ca2+ sequestration

1 reference

https://pubmed.ncbi.nlm.nih.gov/19699645

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Isolation and reconstitution of Ca2+-pump from human and porcine platelets

1 reference

https://pubmed.ncbi.nlm.nih.gov/19699645

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Derivatives of thapsigargin as probes of its binding site on endoplasmic reticulum Ca2+ ATPase. Stereoselectivity and important functional groups

1 reference

https://pubmed.ncbi.nlm.nih.gov/19699645

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The importance of the hydroxyl moieties for inhibition of the Ca(2+)-ATPase by trilobolide and 2,5-di(tert-butyl)-1,4-benzohydroquinone

1 reference

https://pubmed.ncbi.nlm.nih.gov/19699645

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Structure-Activity Relationships of Analogs of Thapsigargin Modified at O-11 and O-12

1 reference

https://pubmed.ncbi.nlm.nih.gov/19699645

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Synthesis and interaction of fluorescent thapsigargin derivatives with the sarcoplasmic reticulum ATPase membrane-bound region

1 reference

https://pubmed.ncbi.nlm.nih.gov/19699645

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interactions of Dihydroxybenzenes with the Ca2+-ATPase: Separate Binding Sites for Dihydroxybenzenes and Sesquiterpene Lactones

1 reference

https://pubmed.ncbi.nlm.nih.gov/19699645

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Novel aromatic isothiouronium derivatives which act as high affinity competitive antagonists of alkali metal cations on Na/K-ATPase

1 reference

https://pubmed.ncbi.nlm.nih.gov/19699645

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

ACTA, a fluorescent analogue of thapsigargin, is a potent inhibitor and a conformational probe of skeletal muscle Ca2+-ATPase

1 reference

https://pubmed.ncbi.nlm.nih.gov/19699645

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Thapsigargin analogues for targeting programmed death of androgen-independent prostate cancer cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/19699645

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Transtaganolides A-D: novel metabolites from Thapsia transtagana

1 reference

https://pubmed.ncbi.nlm.nih.gov/19699645

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1016/J.BMC.2009.07.075

1 reference

Europe PubMed Central

PMC publication ID

17 October 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

17 October 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

17 October 2017

ResearchGate publication ID

0 references

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