(Q42153188)

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Truncated RUNX1 protein generated by a novel t(1;21)(p32;q22) chromosomal translocation impairs the proliferation and differentiation of human hematopoietic progenitors

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Europe PubMed Central

PubMed publication ID

17 October 2017

Truncated RUNX1 protein generated by a novel t(1;21)(p32;q22) chromosomal translocation impairs the proliferation and differentiation of human hematopoietic progenitors (English)

1 reference

Europe PubMed Central

PubMed publication ID

17 October 2017

Raul Torres-Ruiz

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R Torres-Ruiz

2

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Sandra Rodriguez-Perales

object named as

S Rodriguez-Perales

1

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author name string

J Suela

3

1 reference

Europe PubMed Central

PubMed publication ID

17 October 2017

F Acquadro

4

1 reference

Europe PubMed Central

PubMed publication ID

17 October 2017

M C Martin

5

1 reference

Europe PubMed Central

PubMed publication ID

17 October 2017

E Yebra

6

1 reference

Europe PubMed Central

PubMed publication ID

17 October 2017

J C Ramirez

7

1 reference

Europe PubMed Central

PubMed publication ID

17 October 2017

S Alvarez

8

1 reference

Europe PubMed Central

PubMed publication ID

17 October 2017

J C Cigudosa

9

1 reference

Europe PubMed Central

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17 October 2017

language of work or name

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publication date

23 March 2015

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Europe PubMed Central

PubMed publication ID

17 October 2017

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Europe PubMed Central

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17 October 2017

35

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Europe PubMed Central

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17 October 2017

1

1 reference

Europe PubMed Central

PubMed publication ID

17 October 2017

125-134

1 reference

Europe PubMed Central

PubMed publication ID

17 October 2017

https://scigraph.springernature.com/pub.10.1038/onc.2015.70

0 references

Cell cycle and developmental control of hematopoiesis by Runx1.

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.70

21 January 2018

Gatekeeper function of the RUNX1 transcription factor in acute leukemia

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.70

21 January 2018

t(8;21) breakpoints on chromosome 21 in acute myeloid leukemia are clustered within a limited region of a single gene, AML1

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.70

21 January 2018

Role of AML1/Runx1 in the pathogenesis of hematological malignancies

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.70

21 January 2018

The c-myc protein represses the lambda 5 and TdT initiators.

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.70

21 January 2018

Overexpression of an isoform of AML1 in acute leukemia and its potential role in leukemogenesis

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.70

21 January 2018

Isoform-specific potentiation of stem and progenitor cell engraftment by AML1/RUNX1

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.70

21 January 2018

Point mutations in the RUNX1/AML1 gene: another actor in RUNX leukemia

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.70

21 January 2018

Point mutations of the RUNx1/AML1 gene in sporadic and familial myeloid leukemias

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.70

21 January 2018

AML1/RUNX1 mutations are infrequent, but related to AML-M0, acquired trisomy 21, and leukemic transformation in pediatric hematologic malignancies.

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.70

21 January 2018

High incidence of somatic mutations in the AML1/RUNX1 gene in myelodysplastic syndrome and low blast percentage myeloid leukemia with myelodysplasia

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.70

21 January 2018

Haploinsufficiency of CBFA2 causes familial thrombocytopenia with propensity to develop acute myelogenous leukaemia

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.70

21 January 2018

Runx1/AML1 in normal and abnormal hematopoiesis.

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.70

21 January 2018

AML1/RUNX1 mutations in 470 adult patients with de novo acute myeloid leukemia: prognostic implication and interaction with other gene alterations.

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.70

21 January 2018

DNA methylation signatures identify biologically distinct subtypes in acute myeloid leukemia.

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.70

21 January 2018

DNA methylation profiles and their relationship with cytogenetic status in adult acute myeloid leukemia

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.70

21 January 2018

RUNX1 translocations and fusion genes in malignant hemopathies

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.70

21 January 2018

Identification of novel Runx1 (AML1) translocation partner genes SH3D19, YTHDf2, and ZNF687 in acute myeloid leukemia

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.70

21 January 2018

Identification of truncated RUNX1 and RUNX1-PRDM16 fusion transcripts in a case of t(1;21)(p36;q22)-positive therapy-related AML.

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.70

21 January 2018

A novel gene, FGA7, is fused to RUNX1/AML1 in a t(4;21)(q28;q22) in a patient with T-cell acute lymphoblastic leukemia

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.70

21 January 2018

Fusion of AML1/Runx1 to copine VIII, a novel member of the copine family, in an aggressive acute myelogenous leukemia with t(12;21) translocation.

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.70

21 January 2018

The 3;21 translocation in myelodysplasia results in a fusion transcript between the AML1 gene and the gene for EAP, a highly conserved protein associated with the Epstein-Barr virus small RNA EBER 1

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.70

21 January 2018

Ending the message: poly(A) signals then and now

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.70

21 January 2018

Additional acquisition of t(1;21)(p32;q22) in a patient relapsing with acute myelogenous leukemia with NUP98-HOXA9.

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.70

21 January 2018

The AML1-ETO fusion protein promotes the expansion of human hematopoietic stem cells

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.70

21 January 2018

The macrophage transcription factor PU.1 directs tissue-specific expression of the macrophage colony-stimulating factor receptor

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.70

21 January 2018

AML1-ETO interacts with Sp1 and antagonizes Sp1 transactivity through RUNT domain

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.70

21 January 2018

Chromatin modifications induced by the AML1-ETO fusion protein reversibly silence its genomic targets through AML1 and Sp1 binding motifs.

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.70

21 January 2018

Expression of the runt homology domain of RUNX1 disrupts homeostasis of hematopoietic stem cells and induces progression to myelodysplastic syndrome

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.70

21 January 2018

Mutations of AML1 are common in therapy-related myelodysplasia following therapy with alkylating agents and are significantly associated with deletion or loss of chromosome arm 7q and with subsequent leukemic transformation

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.70

21 January 2018

Maintaining the self-renewal and differentiation potential of human CD34+ hematopoietic cells using a single genetic element.

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.70

21 January 2018

The t(8;21) fusion protein interferes with AML-1B-dependent transcriptional activation

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.70

21 January 2018

AML1-ETO expression is directly involved in the development of acute myeloid leukemia in the presence of additional mutations

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.70

21 January 2018

Loss of expression of the Hoxa-9 homeobox gene impairs the proliferation and repopulating ability of hematopoietic stem cells

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.70

21 January 2018

Expression of HOX genes, HOX cofactors, and MLL in phenotypically and functionally defined subpopulations of leukemic and normal human hematopoietic cells

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.70

21 January 2018

MEIS1 and HOXA7 genes in human acute myeloid leukemia

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.70

21 January 2018

Use of gene-expression profiling to identify prognostic subclasses in adult acute myeloid leukemia

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.70

21 January 2018

AML1-ETO reprograms hematopoietic cell fate by downregulating scl expression.

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.70

21 January 2018

Engineering human tumour-associated chromosomal translocations with the RNA-guided CRISPR-Cas9 system

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.70

21 January 2018

An integration-defective lentivirus-based resource for site-specific targeting of an edited safe-harbour locus in the human genome.

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.70

21 January 2018

Erlotinib effectively inhibits JAK2V617F activity and polycythemia vera cell growth

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.70

21 January 2018

The molecular basis of leukemia

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.70

31 March 2020

Diminution of the AML1 transcription factor function causes differential effects on the fates of CD4 and CD8 single-positive T cells

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.70

31 March 2020

An acute myeloid leukemia gene, AML1, regulates hemopoietic myeloid cell differentiation and transcriptional activation antagonistically by two alternative spliced forms.

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.70

31 March 2020

RUNX1 mutations are frequent in de novo AML with noncomplex karyotype and confer an unfavorable prognosis

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.70

31 March 2020

Trisomy 13 is strongly associated with AML1/RUNX1 mutations and increased FLT3 expression in acute myeloid leukemia

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.70

31 March 2020

Trisomy 13 correlates with RUNX1 mutation and increased FLT3 expression in AML-M0 patients.

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.70

31 March 2020

M0 AML, clinical and biologic features of the disease, including AML1 gene mutations: a report of 59 cases by the Groupe Français d'Hématologie Cellulaire (GFHC) and the Groupe Français de Cytogénétique Hématologique (GFCH)

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.70

31 March 2020

RUNX1 gene mutation in primary myelodysplastic syndrome--the mutation can be detected early at diagnosis or acquired during disease progression and is associated with poor outcome

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.70

31 March 2020

Identification of the novel AML1 fusion partner gene, LAF4, a fusion partner of MLL, in childhood T-cell acute lymphoblastic leukemia with t(2;21)(q11;q22) by bubble PCR method for cDNA

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.70

31 March 2020

Fusion gene-mediated truncation of RUNX1 as a potential mechanism underlying disease progression in the 8p11 myeloproliferative syndrome

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.70

31 March 2020

Fusion AML1 transcript in a radiation-associated leukemia results in a truncated inhibitory AML1 protein

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.70

31 March 2020

Acute myeloid leukemia with t(7;21)(q11.2;q22) expresses a novel, reversed-sequence RUNX1-DTX2 chimera

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.70

31 March 2020

A unique AML1 (CBF2A) rearrangement, t(1;21)(p32;q22), observed in a patient with acute myelomonocytic leukemia

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.70

31 March 2020

Quantitative HOX expression in chromosomally defined subsets of acute myelogenous leukemia

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.70

31 March 2020

Cytogenetic analysis of 434 consecutively ascertained specimens of non-Hodgkin's lymphoma: correlations between recurrent aberrations, histology, and exposure to cytotoxic treatment

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.70

31 March 2020

Analysis of the role of AML1-ETO in leukemogenesis, using an inducible transgenic mouse model

1 reference

https://pubmed.ncbi.nlm.nih.gov/25798834

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

High incidence of biallelic point mutations in the Runt domain of the AML1/PEBP2 alpha B gene in Mo acute myeloid leukemia and in myeloid malignancies with acquired trisomy 21

1 reference

https://pubmed.ncbi.nlm.nih.gov/25798834

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Fourth International Workshop on Chromosomes in Leukemia 1982: Translocation (8;21)(q22;q22) in acute nonlymphocytic leukemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/25798834

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Biallelic and heterozygous point mutations in the runt domain of the AML1/PEBP2alphaB gene associated with myeloblastic leukemias

1 reference

https://pubmed.ncbi.nlm.nih.gov/25798834

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Frequent co-expression of the HOXA9 and MEIS1 homeobox genes in human myeloid leukemias

1 reference

https://pubmed.ncbi.nlm.nih.gov/25798834

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alternative splicing and genomic structure of the AML1 gene involved in acute myeloid leukemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/25798834

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

AML1A and AML1B can transactivate the human IL-3 promoter.

1 reference

https://pubmed.ncbi.nlm.nih.gov/25798834

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The AML1/ETO fusion protein blocks transactivation of the GM-CSF promoter by AML1B.

1 reference

https://pubmed.ncbi.nlm.nih.gov/25798834

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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10.1038/ONC.2015.70

1 reference

Europe PubMed Central

PubMed publication ID

17 October 2017

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0 references

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

17 October 2017

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