(Q42167774)

17 October 2017

title

Fuzzy simulation of pharmacokinetic models: case study of whole body physiologically based model of diazepam (English)

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17 October 2017

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Ivelina I Gueorguieva

series ordinal

1

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17 October 2017

Ivan A Nestorov

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2

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17 October 2017

Malcolm Rowland

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3

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17 October 2017

publication date

1 June 2004

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Journal of Pharmacokinetics and Pharmacodynamics

17 October 2017

published in

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17 October 2017

volume

31

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17 October 2017

issue

3

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17 October 2017

page(s)

185-213

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Regional blood flow in conscious resting rats determined by microsphere distribution

17 October 2017

cites work

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Precision and sensitivity of pharmacokinetic models for cancer risk assessment: tetrachloroethylene in mice, rats, and humans

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Biliary excretion of diazepam in the rat.

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Effect of parameter variability on physiologically-based pharmacokinetic model predicted drug concentrations.

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12 December 2020

A Simple Method for Determining Diazepam and Its Major Metabolites in Biological Fluids: Application in Bioavailability Studies

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12 December 2020

Prediction of diazepam disposition in the rat and man by a physiologically based pharmacokinetic model.

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12 December 2020

Fuzzy logic pharmacokinetic modeling: application to lithium concentration prediction.

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12 December 2020

Prediction of in vivo drug metabolism in the human liver from in vitro metabolism data

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12 December 2020

Uncertainties in pharmacokinetic modeling for perchloroethylene. I. Comparison of model structure, parameters, and predictions for low-dose metabolism rates for models derived by different authors

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12 December 2020

Prediction of human clearance of twenty-nine drugs from hepatic microsomal intrinsic clearance data: An examination of in vitro half-life approach and nonspecific binding to microsomes.

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12 December 2020

Evaluation of uncertainty in input parameters to pharmacokinetic models and the resulting uncertainty in output

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12 December 2020

Uncertainty, variability, and sensitivity analysis in physiological pharmacokinetic models.

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12 December 2020

Physiologically based pharmacokinetic modeling of a homologous series of barbiturates in the rat: a sensitivity analysis

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12 December 2020

Variability of physiologically based pharmacokinetic (PBPK) model parameters and their effects on PBPK model predictions in a risk assessment for perchloroethylene (PCE)

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12 December 2020

Use of physiologically based pharmacokinetic modeling to investigate individual versus population risk

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12 December 2020

Optimization issues in physiological toxicokinetic modeling: a case study with benzene.

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12 December 2020

Incorporating measures of variability and uncertainty into the prediction of in vivo hepatic clearance from in vitro data

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12 December 2020

Using fuzzy logic to predict response to citalopram in alcohol dependence.

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12 December 2020

Kinetics of diazepam metabolism in rat hepatic microsomes and hepatocytes and their use in predicting in vivo hepatic clearance.

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12 December 2020

The prediction of human pharmacokinetic parameters from preclinical and in vitro metabolism data.

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12 December 2020

Analysis of PBPK models for risk characterization

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12 December 2020

Statistical methods for population pharmacokinetic modelling

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12 December 2020

10.1023/B:JOPA.0000039564.35602.78

Identifiers

DOI

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Dimensions Publication ID

17 October 2017

1037891246

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