(Q42170222)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12843267%20AND%20SRC:MED&resulttype=core&format=json

5 November 2019

title

Presenilin redistribution associated with aberrant cholesterol transport enhances beta-amyloid production in vivo (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12843267%20AND%20SRC:MED&resulttype=core&format=json

5 November 2019

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12843267%20AND%20SRC:MED&resulttype=core&format=json

5 November 2019

Mark P Burns

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12843267%20AND%20SRC:MED&resulttype=core&format=json

5 November 2019

author name string

Kate Gaynor

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12843267%20AND%20SRC:MED&resulttype=core&format=json

5 November 2019

Vicki Olm

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12843267%20AND%20SRC:MED&resulttype=core&format=json

5 November 2019

Marc Mercken

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12843267%20AND%20SRC:MED&resulttype=core&format=json

5 November 2019

John LaFrancois

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12843267%20AND%20SRC:MED&resulttype=core&format=json

5 November 2019

Lili Wang

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12843267%20AND%20SRC:MED&resulttype=core&format=json

5 November 2019

Wendy Noble

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12843267%20AND%20SRC:MED&resulttype=core&format=json

5 November 2019

Yasuji Matsuoka

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12843267%20AND%20SRC:MED&resulttype=core&format=json

5 November 2019

Karen Duff

10

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12843267%20AND%20SRC:MED&resulttype=core&format=json

5 November 2019

language of work or name

English

0 references

publication date

1 July 2003

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12843267%20AND%20SRC:MED&resulttype=core&format=json

5 November 2019

published in

Journal of Neuroscience

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12843267%20AND%20SRC:MED&resulttype=core&format=json

5 November 2019

volume

23

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12843267%20AND%20SRC:MED&resulttype=core&format=json

5 November 2019

issue

13

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12843267%20AND%20SRC:MED&resulttype=core&format=json

5 November 2019

page(s)

5645-5649

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12843267%20AND%20SRC:MED&resulttype=core&format=json

Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity

5 November 2019

cites work

1 reference

12 December 2020

Cholesterol accumulation in tissues of the Niemann-pick type C mouse is determined by the rate of lipoprotein-cholesterol uptake through the coated-pit pathway in each organ

1 reference

12 December 2020

Alzheimer's disease. Closing in on gamma-secretase.

1 reference

12 December 2020

Hypercholesterolemia accelerates the Alzheimer's amyloid pathology in a transgenic mouse model

1 reference

12 December 2020

Decreased prevalence of Alzheimer disease associated with 3-hydroxy-3-methyglutaryl coenzyme A reductase inhibitors.

1 reference

12 December 2020

Accumulation and aggregation of amyloid beta-protein in late endosomes of Niemann-pick type C cells

1 reference

12 December 2020

Statins and the risk of dementia

1 reference

12 December 2020

Cholesterol is sequestered in the brains of mice with Niemann-Pick type C disease but turnover is increased.

1 reference

12 December 2020

Age-dependent changes in brain, CSF, and plasma amyloid (beta) protein in the Tg2576 transgenic mouse model of Alzheimer's disease.

1 reference

12 December 2020

Acyl-coenzyme A: cholesterol acyltransferase modulates the generation of the amyloid beta-peptide

1 reference

12 December 2020

A cholesterol-lowering drug reduces beta-amyloid pathology in a transgenic mouse model of Alzheimer's disease

1 reference

12 December 2020

The beta-secretase, BACE: a prime drug target for Alzheimer's disease

1 reference

12 December 2020

Cholesterol-dependent gamma-secretase activity in buoyant cholesterol-rich membrane microdomains

1 reference

12 December 2020

Inhibition of intracellular cholesterol transport alters presenilin localization and amyloid precursor protein processing in neuronal cells.

1 reference

12 December 2020

Statin therapy for Alzheimer's disease: will it work?

1 reference

12 December 2020

Lipid rafts play an important role in A beta biogenesis by regulating the beta-secretase pathway

1 reference

12 December 2020

Secretion of apolipoprotein E by an astrocytoma cell line

1 reference

12 December 2020

Intracellular accumulation of amyloidogenic fragments of amyloid-beta precursor protein in neurons with Niemann-Pick type C defects is associated with endosomal abnormalities

1 reference

12 December 2020

Astrocytic apolipoprotein E mRNA and GFAP mRNA in hippocampus after entorhinal cortex lesioning

1 reference

12 December 2020

Oligodendrocytes but not astrocytes express apolipoprotein E after injury of rat optic nerve

1 reference

12 December 2020

Apolipoprotein E associated with astrocytic glia of the central nervous system and with nonmyelinating glia of the peripheral nervous system

1 reference

12 December 2020

Cholesterol modulates alpha-secretase cleavage of amyloid precursor protein

1 reference

12 December 2020

Intracellular trafficking of cholesterol monitored with a cyclodextrin

1 reference

12 December 2020

Niemann-Pick C1 disease gene: homology to mediators of cholesterol homeostasis

1 reference

12 December 2020

Murine model of Niemann-Pick C disease: mutation in a cholesterol homeostasis gene

1 reference

12 December 2020

Turnover of amyloid beta-protein in mouse brain and acute reduction of its level by phorbol ester.

1 reference

12 December 2020

Separation of early steps in endocytic membrane transport

1 reference

12 December 2020

Cholesterol depletion inhibits the generation of beta-amyloid in hippocampal neurons

1 reference

12 December 2020

A detergent-insoluble membrane compartment contains A beta in vivo

1 reference

12 December 2020

Cholesterol balance and metabolism in mice with loss of function of Niemann-Pick C protein.

1 reference

12 December 2020

10.1523/JNEUROSCI.23-13-05645.2003

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12843267%20AND%20SRC:MED&resulttype=core&format=json

5 November 2019

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12843267%20AND%20SRC:MED&resulttype=core&format=json

5 November 2019

PubMed publication ID

12843267

1 reference