(Q42181792)

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In vitro antiviral activity and preclinical and clinical resistance profile of miravirsen, a novel anti-hepatitis C virus therapeutic targeting the human factor miR-122.

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scholarly article

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Europe PubMed Central

18 October 2017

In vitro antiviral activity and preclinical and clinical resistance profile of miravirsen, a novel anti-hepatitis C virus therapeutic targeting the human factor miR-122. (English)

1 reference

Europe PubMed Central

18 October 2017

Hepatitis C virus

1 reference

based on heuristic

inferred from title

author name string

Søren Ottosen

1

1 reference

Europe PubMed Central

18 October 2017

Todd B Parsley

2

1 reference

Europe PubMed Central

18 October 2017

Lu Yang

3

1 reference

Europe PubMed Central

18 October 2017

Karin Zeh

4

1 reference

Europe PubMed Central

18 October 2017

Leen-Jan van Doorn

5

1 reference

Europe PubMed Central

18 October 2017

Eva van der Veer

6

1 reference

Europe PubMed Central

18 October 2017

Anneke K Raney

7

1 reference

Europe PubMed Central

18 October 2017

Michael R Hodges

8

1 reference

Europe PubMed Central

18 October 2017

Amy K Patick

9

1 reference

Europe PubMed Central

18 October 2017

language of work or name

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publication date

10 November 2014

1 reference

Europe PubMed Central

18 October 2017

Antimicrobial Agents and Chemotherapy

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Europe PubMed Central

18 October 2017

59

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Europe PubMed Central

18 October 2017

1

1 reference

Europe PubMed Central

18 October 2017

599-608

1 reference

Europe PubMed Central

18 October 2017

Hepatitis C virus subverts liver-specific miR-122 to protect the viral genome from exoribonuclease Xrn2.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4291405

26 October 2017

Identification of PTC725, an orally bioavailable small molecule that selectively targets the hepatitis C Virus NS4B protein

1 reference

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26 October 2017

Treatment of HCV infection by targeting microRNA

1 reference

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26 October 2017

Profile of alisporivir and its potential in the treatment of hepatitis C.

1 reference

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26 October 2017

Unconventional miR-122 binding stabilizes the HCV genome by forming a trimolecular RNA structure

1 reference

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26 October 2017

Competing and noncompeting activities of miR-122 and the 5' exonuclease Xrn1 in regulation of hepatitis C virus replication.

1 reference

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26 October 2017

MicroRNA therapeutics for cardiovascular disease: opportunities and obstacles.

1 reference

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26 October 2017

miR-34 - a microRNA replacement therapy is headed to the clinic

1 reference

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26 October 2017

Treating hepatitis C infection by targeting the host

1 reference

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26 October 2017

New antiviral therapies in the management of HCV infection

1 reference

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26 October 2017

Evaluation of ITX 5061, a scavenger receptor B1 antagonist: resistance selection and activity in combination with other hepatitis C virus antivirals

1 reference

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26 October 2017

Preliminary study of two antiviral agents for hepatitis C genotype 1.

1 reference

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26 October 2017

Arrest all accessories--inhibition of hepatitis C virus by compounds that target host factors.

1 reference

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26 October 2017

Comparative study of the genetic barriers and pathways towards resistance of selective inhibitors of hepatitis C virus replication

1 reference

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26 October 2017

Mutations in HCV non-structural genes do not contribute to resistance to nitazoxanide in replicon-containing cells.

1 reference

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26 October 2017

MicroRNA-122 antagonism against hepatitis C virus genotypes 1-6 and reduced efficacy by host RNA insertion or mutations in the HCV 5' UTR.

1 reference

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26 October 2017

New opportunities in anti-hepatitis C virus drug discovery: targeting NS4B.

1 reference

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26 October 2017

Masking the 5' terminal nucleotides of the hepatitis C virus genome by an unconventional microRNA-target RNA complex.

1 reference

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26 October 2017

New HCV therapies on the horizon

1 reference

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26 October 2017

DEB025 (Alisporivir) inhibits hepatitis C virus replication by preventing a cyclophilin A induced cis-trans isomerisation in domain II of NS5A

1 reference

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26 October 2017

Therapeutic silencing of microRNA-122 in primates with chronic hepatitis C virus infection

1 reference

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26 October 2017

Efficient gene silencing by delivery of locked nucleic acid antisense oligonucleotides, unassisted by transfection reagents

1 reference

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26 October 2017

microRNA-122 stimulates translation of hepatitis C virus RNA

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4291405

26 October 2017

Position-dependent function for a tandem microRNA miR-122-binding site located in the hepatitis C virus RNA genome

1 reference

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26 October 2017

LNA-mediated microRNA silencing in non-human primates

1 reference

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26 October 2017

Relative Replication Capacity and Selective Advantage Profiles of Protease Inhibitor-Resistant Hepatitis C Virus (HCV) NS3 Protease Mutants in the HCV Genotype 1b Replicon System

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4291405

26 October 2017

Interferon modulation of cellular microRNAs as an antiviral mechanism

1 reference

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26 October 2017

Cellular cofactors affecting hepatitis C virus infection and replication

1 reference

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The muscle-specific microRNA miR-1 regulates cardiac arrhythmogenic potential by targeting GJA1 and KCNJ2

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Suppression of microRNA-silencing pathway by HIV-1 during virus replication

1 reference

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Reduced maximal inhibition in phenotypic susceptibility assays indicates that viral strains resistant to the CCR5 antagonist maraviroc utilize inhibitor-bound receptor for entry

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Oncomirs - microRNAs with a role in cancer

1 reference

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miR-122 regulation of lipid metabolism revealed by in vivo antisense targeting

1 reference

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Silencing of microRNAs in vivo with 'antagomirs'

1 reference

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26 October 2017

Modulation of hepatitis C virus RNA abundance by a liver-specific MicroRNA

1 reference

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26 October 2017

Global epidemiology of hepatitis C virus infection

1 reference

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26 October 2017

MicroRNA expression profiles classify human cancers

1 reference

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A microRNA polycistron as a potential human oncogene

1 reference

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Viral and Cellular Determinants of Hepatitis C Virus RNA Replication in Cell Culture

1 reference

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Replication of subgenomic hepatitis C virus RNAs in a hepatoma cell line

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A three-dimensional model to analyze drug-drug interactions

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In vitro resistance studies of hepatitis C virus serine protease inhibitors, VX-950 and BILN 2061: structural analysis indicates different resistance mechanisms

1 reference

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17 August 2018

Identifiers

10.1128/AAC.04220-14

1 reference

Europe PubMed Central

18 October 2017

1 reference

Europe PubMed Central

18 October 2017

1 reference

Europe PubMed Central

18 October 2017

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