(Q42198254)

18 October 2017

1,3-Dimethyl Benzimidazolones Are Potent, Selective Inhibitors of the BRPF1 Bromodomain (English)

1 reference

18 October 2017

12

Anne-Marie Michon

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Paola Grandi

7

object named as

Paola Grandi

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Chun-Wa Chung

3

object named as

Chun-Wa Chung

1 reference

18 October 2017

Emmanuel H Demont

1

1 reference

18 October 2017

Paul Bamborough

2

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18 October 2017

Peter D Craggs

4

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18 October 2017

David Fallon

5

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18 October 2017

Laurie J Gordon

6

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18 October 2017

Paola Grandi

7

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18 October 2017

Clare I Hobbs

8

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18 October 2017

Jameed Hussain

9

1 reference

18 October 2017

Emma J Jones

10

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18 October 2017

Armelle Le Gall

11

1 reference

18 October 2017

Anne-Marie Michon

12

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18 October 2017

Darren J Mitchell

13

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18 October 2017

Rab K Prinjha

14

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18 October 2017

Andy D Roberts

15

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18 October 2017

Robert J Sheppard

16

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18 October 2017

Robert J Watson

17

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18 October 2017

10 September 2014

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ACS Medicinal Chemistry Letters

18 October 2017

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18 October 2017

5

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18 October 2017

11

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18 October 2017

1190-1195

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The MOZ histone acetyltransferase in epigenetic signaling and disease.

18 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4233354

RVX-208, an inducer of ApoA-I in humans, is a BET bromodomain antagonist

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4233354

Molecular insights into the recognition of N-terminal histone modifications by the BRPF1 bromodomain.

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4233354

BET bromodomain inhibitors: a patent review

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4233354

Exchange of associated factors directs a switch in HBO1 acetyltransferase histone tail specificity.

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4233354

Fragment-based drug discovery of 2-thiazolidinones as inhibitors of the histone reader BRD4 bromodomain

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4233354

Optimization of 3,5-Dimethylisoxazole Derivatives as Potent Bromodomain Ligands

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4233354

TET2 and TET3 regulate GlcNAcylation and H3K4 methylation through OGT and SET1/COMPASS

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4233354

Progress in the development and application of small molecule inhibitors of bromodomain-acetyl-lysine interactions

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4233354

Histone recognition and large-scale structural analysis of the human bromodomain family

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4233354

Fragment-based discovery of bromodomain inhibitors part 2: optimization of phenylisoxazole sulfonamides

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4233354

Fragment-based discovery of bromodomain inhibitors part 1: inhibitor binding modes and implications for lead discovery

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4233354

Recognition of unmodified histone H3 by the first PHD finger of bromodomain-PHD finger protein 2 provides insights into the regulation of histone acetyltransferases monocytic leukemic zinc-finger protein (MOZ) and MOZ-related factor (MORF)

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4233354

The Hbo1-Brd1/Brpf2 complex is responsible for global acetylation of H3K14 and required for fetal liver erythropoiesis.

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4233354

Discovery and characterization of small molecule inhibitors of the BET family bromodomains

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4233354

Suppression of inflammation by a synthetic histone mimic

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4233354

Selective inhibition of BET bromodomains

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4233354

Molecular basis of histone H3K36me3 recognition by the PWWP domain of Brpf1

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4233354

Molecular architecture of quartet MOZ/MORF histone acetyltransferase complexes

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4233354

The multidomain protein Brpf1 binds histones and is required for Hox gene expression and segmental identity

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4233354

Support of association between BRD1 and both schizophrenia and bipolar affective disorder.

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4233354

2,3-Dihydro-2-oxo-1H-benzimidazole-1-carboxamides with selective affinity for the 5-HT(4) receptor: synthesis and structure-affinity and structure-activity relationships of a new series of partial agonist and antagonist derivatives

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4233354

17 August 2018

Identifiers

DOI

10.1021/ML5002932

1 reference

18 October 2017

1 reference

18 October 2017

PubMed publication ID

25408830

1 reference