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A single amino acid substitution in the novel H7N9 influenza A virus NS1 protein increases CPSF30 binding and virulence.
scientific article published on 30 July 2014
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scholarly article
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Europe PubMed Central
PMC publication ID
4178744
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25078692%20AND%20SRC:MED&resulttype=core&format=json
retrieved
11 March 2020
title
A single amino acid substitution in the novel H7N9 influenza A virus NS1 protein increases CPSF30 binding and virulence
(English)
1 reference
stated in
Europe PubMed Central
PMC publication ID
4178744
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25078692%20AND%20SRC:MED&resulttype=core&format=json
retrieved
11 March 2020
author
Adolfo García-Sastre
series ordinal
7
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Europe PubMed Central
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4178744
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25078692%20AND%20SRC:MED&resulttype=core&format=json
retrieved
11 March 2020
Patricia Domingues
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2
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Europe PubMed Central
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4178744
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25078692%20AND%20SRC:MED&resulttype=core&format=json
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11 March 2020
Benjamin G Hale
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6
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4178744
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25078692%20AND%20SRC:MED&resulttype=core&format=json
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11 March 2020
Mirco Schmolke
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5
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Mirco Schmolke
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Europe PubMed Central
PMC publication ID
4178744
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25078692%20AND%20SRC:MED&resulttype=core&format=json
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11 March 2020
Lisa Miorin
series ordinal
4
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Lisa Miorin
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Europe PubMed Central
PMC publication ID
4178744
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25078692%20AND%20SRC:MED&resulttype=core&format=json
retrieved
11 March 2020
Ricardo Rajsbaum
series ordinal
3
object named as
Ricardo Rajsbaum
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Europe PubMed Central
PMC publication ID
4178744
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25078692%20AND%20SRC:MED&resulttype=core&format=json
retrieved
11 March 2020
author name string
Juan Ayllon
series ordinal
1
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4178744
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11 March 2020
language of work or name
English
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publication date
30 July 2014
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Europe PubMed Central
PMC publication ID
4178744
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retrieved
11 March 2020
published in
Journal of Virology
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Europe PubMed Central
PMC publication ID
4178744
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25078692%20AND%20SRC:MED&resulttype=core&format=json
retrieved
11 March 2020
volume
88
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4178744
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11 March 2020
issue
20
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Europe PubMed Central
PMC publication ID
4178744
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25078692%20AND%20SRC:MED&resulttype=core&format=json
retrieved
11 March 2020
page(s)
12146-12151
1 reference
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Europe PubMed Central
PMC publication ID
4178744
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25078692%20AND%20SRC:MED&resulttype=core&format=json
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11 March 2020
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Amino acid substitutions in polymerase basic protein 2 gene contribute to the pathogenicity of the novel A/H7N9 influenza virus in mammalian hosts.
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PubMed Central
reference URL
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The PB2 E627K mutation contributes to the high polymerase activity and enhanced replication of H7N9 influenza virus.
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Virulence-affecting amino acid changes in the PA protein of H7N9 influenza A viruses
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Influenza A(H7N9) virus gains neuraminidase inhibitor resistance without loss of in vivo virulence or transmissibility.
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Preferential Recognition of Avian-Like Receptors in Human Influenza A H7N9 Viruses
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The novel human influenza A(H7N9) virus is naturally adapted to efficient growth in human lung tissue.
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H7N9 influenza viruses interact preferentially with α2,3-linked sialic acids and bind weakly to α2,6-linked sialic acids
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Influenza A/Hong Kong/156/1997(H5N1) virus NS1 gene mutations F103L and M106I both increase IFN antagonism, virulence and cytoplasmic localization but differ in binding to RIG-I and CPSF30
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The virulence of 1997 H5N1 influenza viruses in the mouse model is increased by correcting a defect in their NS1 proteins
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Influenza A virus strains that circulate in humans differ in the ability of their NS1 proteins to block the activation of IRF3 and interferon-β transcription
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Glycine 184 in nonstructural protein NS1 determines the virulence of influenza A virus strain PR8 without affecting the host interferon response
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Inefficient control of host gene expression by the 2009 pandemic H1N1 influenza A virus NS1 protein
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26 October 2017
Association of RIG-I with innate immunity of ducks to influenza
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26 October 2017
Influenza A virus NS1 targets the ubiquitin ligase TRIM25 to evade recognition by the host viral RNA sensor RIG-I
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26 October 2017
Influenza a virus polymerase is an integral component of the CPSF30-NS1A protein complex in infected cells
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26 October 2017
The multifunctional NS1 protein of influenza A viruses
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Influenza B virus NS1-truncated mutants: live-attenuated vaccine approach
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26 October 2017
Structural basis for suppression of a host antiviral response by influenza A virus
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The H5N1 influenza virus NS genes selected after 1998 enhance virus replication in mammalian cells
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Multiple anti-interferon actions of the influenza A virus NS1 protein
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Inhibition of retinoic acid-inducible gene I-mediated induction of beta interferon by the NS1 protein of influenza A virus
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Variation in the ability of human influenza A viruses to induce and inhibit the IFN-beta pathway.
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26 October 2017
Cellular antiviral responses against influenza A virus are countered at the posttranscriptional level by the viral NS1A protein via its binding to a cellular protein required for the 3' end processing of cellular pre-mRNAS
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26 October 2017
Influenza virus NS1 protein interacts with the cellular 30 kDa subunit of CPSF and inhibits 3'end formation of cellular pre-mRNAs
1 reference
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26 October 2017
Identifiers
DOI
10.1128/JVI.01567-14
1 reference
stated in
Europe PubMed Central
PMC publication ID
4178744
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25078692%20AND%20SRC:MED&resulttype=core&format=json
retrieved
11 March 2020
PMC publication ID
4178744
1 reference
stated in
Europe PubMed Central
PMC publication ID
4178744
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25078692%20AND%20SRC:MED&resulttype=core&format=json
retrieved
11 March 2020
PubMed publication ID
25078692
1 reference
stated in
Europe PubMed Central
PMC publication ID
4178744
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25078692%20AND%20SRC:MED&resulttype=core&format=json
retrieved
11 March 2020
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