(Q42214617)

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Fibroblast growth factor receptor 3 activation plays a causative role in urothelial cancer pathogenesis in cooperation with Pten loss in mice

scientific article published on 31 March 2014

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

18 October 2017

Fibroblast growth factor receptor 3 activation plays a causative role in urothelial cancer pathogenesis in cooperation with Pten loss in mice (English)

1 reference

Europe PubMed Central

PMC publication ID

18 October 2017

1 reference

based on heuristic

inferred from title

1

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Europe PubMed Central

PMC publication ID

18 October 2017

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Europe PubMed Central

PMC publication ID

18 October 2017

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Europe PubMed Central

PMC publication ID

18 October 2017

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Europe PubMed Central

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18 October 2017

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Europe PubMed Central

PMC publication ID

18 October 2017

object named as

Louise King

6

0 references

Theodorus H Van der Kwast

object named as

Theodorus van der Kwast

4

0 references

Bas W van Rhijn

3

object named as

Bas W G van Rhijn

1 reference

Europe PubMed Central

PMC publication ID

18 October 2017

author name string

Andre M Bergman

5

1 reference

Europe PubMed Central

PMC publication ID

18 October 2017

Rachel Ridgway

7

1 reference

Europe PubMed Central

PMC publication ID

18 October 2017

Sioban Fraser

9

1 reference

Europe PubMed Central

PMC publication ID

18 October 2017

publication date

31 March 2014

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Europe PubMed Central

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18 October 2017

Journal of Pathology

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Europe PubMed Central

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18 October 2017

233

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Europe PubMed Central

PMC publication ID

18 October 2017

2

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Europe PubMed Central

PMC publication ID

18 October 2017

148-158

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Europe PubMed Central

PMC publication ID

18 October 2017

describes a project that uses

1 reference

Europe PubMed Central

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC4612374/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

Exploring mechanisms of FGF signalling through the lens of structural biology

1 reference

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26 October 2017

FGFR3 targeting strategies for achondroplasia

1 reference

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26 October 2017

A molecular taxonomy for urothelial carcinoma.

1 reference

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26 October 2017

Molecular pathways: fibroblast growth factor signaling: a new therapeutic opportunity in cancer

1 reference

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AZD4547: an orally bioavailable, potent, and selective inhibitor of the fibroblast growth factor receptor tyrosine kinase family

1 reference

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26 October 2017

Mechanisms of FGFR-mediated carcinogenesis

1 reference

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26 October 2017

Discovery of 3-(2,6-dichloro-3,5-dimethoxy-phenyl)-1-{6-[4-(4-ethyl-piperazin-1-yl)-phenylamino]-pyrimidin-4-yl}-1-methyl-urea (NVP-BGJ398), a potent and selective inhibitor of the fibroblast growth factor receptor family of receptor tyrosine kinase

1 reference

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26 October 2017

Phosphatidylinositol 3'-kinase, mTOR, and glycogen synthase kinase-3β mediated regulation of p21 in human urothelial carcinoma cells

1 reference

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26 October 2017

K-Ras and β-catenin mutations cooperate with Fgfr3 mutations in mice to promote tumorigenesis in the skin and lung, but not in the bladder.

1 reference

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26 October 2017

Hedgehog/Wnt feedback supports regenerative proliferation of epithelial stem cells in bladder

1 reference

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26 October 2017

Small molecule FGF receptor inhibitors block FGFR-dependent urothelial carcinoma growth in vitro and in vivo.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4612374

26 October 2017

FGFR3, HRAS, KRAS, NRAS and PIK3CA mutations in bladder cancer and their potential as biomarkers for surveillance and therapy.

1 reference

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26 October 2017

β-Catenin activation synergizes with PTEN loss to cause bladder cancer formation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4612374

26 October 2017

Molecular pathways of urothelial development and bladder tumorigenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4612374

26 October 2017

A modified sleeping beauty transposon system that can be used to model a wide variety of human cancers in mice

1 reference

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26 October 2017

AKT1 mutations in bladder cancer: identification of a novel oncogenic mutation that can co-operate with E17K.

1 reference

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26 October 2017

Fibroblast growth factor receptor 1 promotes proliferation and survival via activation of the mitogen-activated protein kinase pathway in bladder cancer

1 reference

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26 October 2017

Antibody-based targeting of FGFR3 in bladder carcinoma and t(4;14)-positive multiple myeloma in mice

1 reference

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26 October 2017

Fibroblast growth factor signaling in development of the cerebral cortex

1 reference

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26 October 2017

Inactivation of p53 and Pten promotes invasive bladder cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4612374

26 October 2017

The updated EAU guidelines on muscle-invasive and metastatic bladder cancer

1 reference

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26 October 2017

Molecular pathogenesis of bladder cancer

1 reference

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26 October 2017

FGFR3 protein expression and its relationship to mutation status and prognostic variables in bladder cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4612374

26 October 2017

Molecular profiling of bladder tumors based on the detection of FGFR3 and TP53 mutations

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4612374

26 October 2017

PIK3CA mutations are an early genetic alteration associated with FGFR3 mutations in superficial papillary bladder tumors.

1 reference

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Roles of uroplakins in plaque formation, umbrella cell enlargement, and urinary tract diseases.

1 reference

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26 October 2017

Defective lysosomal targeting of activated fibroblast growth factor receptor 3 in achondroplasia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4612374

26 October 2017

Frequent FGFR3 mutations in papillary non-invasive bladder (pTa) tumors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4612374

26 October 2017

Activated fibroblast growth factor receptor 3 is an oncogene that contributes to tumor progression in multiple myeloma

1 reference

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26 October 2017

Z/EG, a double reporter mouse line that expresses enhanced green fluorescent protein upon Cre-mediated excision

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4612374

26 October 2017

PIK3CA mutation spectrum in urothelial carcinoma reflects cell context-dependent signaling and phenotypic outputs

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4612374

29 May 2018

Activating mutations of the tyrosine kinase receptor FGFR3 are associated with benign skin tumors in mice and humans

1 reference

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29 May 2018

Cre/loxP-mediated inactivation of the murine Pten tumor suppressor gene.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4612374

29 May 2018

PIK3CA gene alterations in bladder cancer are frequent and associate with reduced recurrence in non-muscle invasive tumors

1 reference

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A comprehensive immunohistochemical and molecular approach to the PI3K/AKT/mTOR (phosphoinositide 3-kinase/v-akt murine thymoma viral oncogene/mammalian target of rapamycin) pathway in bladder urothelial carcinoma.

1 reference

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17 August 2018

Spectrum of phosphatidylinositol 3-kinase pathway gene alterations in bladder cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4612374

17 August 2018

Hyperplasia and carcinomas in Pten-deficient mice and reduced PTEN protein in human bladder cancer patients.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4612374

17 August 2018

Molecular characterization of early-stage bladder carcinomas by expression profiles, FGFR3 mutation status, and loss of 9q.

1 reference

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17 August 2018

Pten deficiency activates distinct downstream signaling pathways in a tissue-specific manner

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4612374

17 August 2018

Role of activating fibroblast growth factor receptor 3 mutations in the development of bladder tumors.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4612374

17 August 2018

FGFR3 and Ras gene mutations are mutually exclusive genetic events in urothelial cell carcinoma.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4612374

17 August 2018

Highly activated Fgfr3 with the K644M mutation causes prolonged survival in severe dwarf mice

1 reference

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17 August 2018

A neonatal lethal mutation in FGFR3 uncouples proliferation and differentiation of growth plate chondrocytes in embryos.

1 reference

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17 August 2018

PI3K/AKT pathway activation in bladder carcinogenesis

1 reference

https://api.crossref.org/works/10.1002%2FPATH.4334

21 January 2018

Mutations in FGFR3 and PIK3CA, singly or combined with RAS and AKT1, are associated with AKT but not with MAPK pathway activation in urothelial bladder cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/24519156

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

FrequentFGFR3mutations in urothelial papilloma

1 reference

https://pubmed.ncbi.nlm.nih.gov/24519156

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Urothelium-specific expression of an oncogene in transgenic mice induced the formation of carcinoma in situ and invasive transitional cell carcinoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/24519156

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Gene deletion in urothelium by specific expression of Cre recombinase

1 reference

https://pubmed.ncbi.nlm.nih.gov/24519156

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tumor progression and survival of patients with high grade, noninvasive papillary (TaG3) bladder tumors: 15-year outcome

1 reference

https://pubmed.ncbi.nlm.nih.gov/24519156

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1002/PATH.4334

1 reference

Europe PubMed Central

PMC publication ID

18 October 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

18 October 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

18 October 2017

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