(Q42234691)

English

Evaluation of the Safety and Biodistribution of M032, an Attenuated HSV-1 Virus Expressing hIL-12, After Intracerebral Administration to Aotus Non-Human Primates

scientific article published on 28 February 2014

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

19 October 2017

Evaluation of the Safety and Biodistribution of M032, an Attenuated HSV-1 Virus Expressing hIL-12, After Intracerebral Administration to Aotus Non-Human Primates (English)

1 reference

Europe PubMed Central

PubMed publication ID

19 October 2017

Herpes simplex virus type 1

1 reference

based on heuristic

inferred from title

author name string

Justin Charles Roth

1

1 reference

Europe PubMed Central

PubMed publication ID

19 October 2017

Kevin A Cassady

2

1 reference

Europe PubMed Central

PubMed publication ID

19 October 2017

James J Cody

3

1 reference

Europe PubMed Central

PubMed publication ID

19 October 2017

Jackie N Parker

4

1 reference

Europe PubMed Central

PubMed publication ID

19 October 2017

Kathleen H Price

5

1 reference

Europe PubMed Central

PubMed publication ID

19 October 2017

Jennifer M Coleman

6

1 reference

Europe PubMed Central

PubMed publication ID

19 October 2017

James O Peggins

7

1 reference

Europe PubMed Central

PubMed publication ID

19 October 2017

Patricia E Noker

8

1 reference

Europe PubMed Central

PubMed publication ID

19 October 2017

Nicholas Powers

9

1 reference

Europe PubMed Central

PubMed publication ID

19 October 2017

Sheila Grimes

10

1 reference

Europe PubMed Central

PubMed publication ID

19 October 2017

Steven L Carroll

11

1 reference

Europe PubMed Central

PubMed publication ID

19 October 2017

G Yancey Gillespie

12

1 reference

Europe PubMed Central

PubMed publication ID

19 October 2017

Richard Whitley

13

1 reference

Europe PubMed Central

PubMed publication ID

19 October 2017

James Markert

14

1 reference

Europe PubMed Central

PubMed publication ID

19 October 2017

language of work or name

1 reference

based on heuristic

inferred from title

publication date

28 February 2014

1 reference

Europe PubMed Central

PubMed publication ID

19 October 2017

Human gene therapy. Clinical development

1 reference

Europe PubMed Central

PubMed publication ID

19 October 2017

HSV1716 injection into the brain adjacent to tumour following surgical resection of high-grade glioma: safety data and long-term survival

1 reference

https://pubmed.ncbi.nlm.nih.gov/24649838

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Oncolytic viruses: clinical applications as vectors for the treatment of malignant gliomas

1 reference

https://pubmed.ncbi.nlm.nih.gov/24649838

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Oncolytic viral therapy of malignant glioma

1 reference

https://pubmed.ncbi.nlm.nih.gov/24649838

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The potential for efficacy of the modified (ICP 34.5(-)) herpes simplex virus HSV1716 following intratumoural injection into human malignant glioma: a proof of principle study

1 reference

https://pubmed.ncbi.nlm.nih.gov/24649838

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Oncolytic HSV armed with platelet factor 4, an antiangiogenic agent, shows enhanced efficacy.

1 reference

https://pubmed.ncbi.nlm.nih.gov/24649838

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Antitumor efficacy of 34.5ENVE: a transcriptionally retargeted and "Vstat120"-expressing oncolytic virus

1 reference

https://pubmed.ncbi.nlm.nih.gov/24649838

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Angiogenesis inhibition using an oncolytic herpes simplex virus expressing endostatin in a murine lung cancer model

1 reference

https://pubmed.ncbi.nlm.nih.gov/24649838

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interleukin-12 and the regulation of innate resistance and adaptive immunity

1 reference

https://pubmed.ncbi.nlm.nih.gov/24649838

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The gamma(1)34.5 protein of herpes simplex virus 1 complexes with protein phosphatase 1alpha to dephosphorylate the alpha subunit of the eukaryotic translation initiation factor 2 and preclude the shutoff of protein synthesis by double-stranded RNA-

1 reference

https://pubmed.ncbi.nlm.nih.gov/24649838

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Oncolytic herpes simplex virus 1 encoding 15-prostaglandin dehydrogenase mitigates immune suppression and reduces ectopic primary and metastatic breast cancer in mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/24649838

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activated MEK suppresses activation of PKR and enables efficient replication and in vivo oncolysis by Deltagamma(1)34.5 mutants of herpes simplex virus 1

1 reference

https://pubmed.ncbi.nlm.nih.gov/24649838

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Preclinical safety evaluation of G207, a replication-competent herpes simplex virus type 1, inoculated intraprostatically in mice and nonhuman primates

1 reference

https://pubmed.ncbi.nlm.nih.gov/24649838

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Synergistic engagement of an ineffective endogenous anti-tumor immune response and induction of IFN-gamma and Fas-ligand-dependent tumor eradication by combined administration of IL-18 and IL-2

1 reference

https://pubmed.ncbi.nlm.nih.gov/24649838

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Viral shedding and biodistribution of G207, a multimutated, conditionally replicating herpes simplex virus type 1, after intracerebral inoculation in aotus.

1 reference

https://pubmed.ncbi.nlm.nih.gov/24649838

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A novel multiply-mutated HSV-1 strain for the treatment of human brain tumors.

1 reference

https://pubmed.ncbi.nlm.nih.gov/24649838

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A clinico-pathological study of herpes simplex encephalitis

1 reference

https://pubmed.ncbi.nlm.nih.gov/24649838

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Angiostatin anti-angiogenesis requires IL-12: the innate immune system as a key target

1 reference

https://pubmed.ncbi.nlm.nih.gov/24649838

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Construction and characterization of an oncolytic HSV vector containing a fusogenic glycoprotein and prodrug activation for enhanced local tumor control

1 reference

https://pubmed.ncbi.nlm.nih.gov/24649838

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Increased efficacy of an interleukin-12-secreting herpes simplex virus in a syngeneic intracranial murine glioma model

1 reference

https://pubmed.ncbi.nlm.nih.gov/24649838

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Conditionally replicating herpes simplex virus mutant, G207 for the treatment of malignant glioma: results of a phase I trial

1 reference

https://pubmed.ncbi.nlm.nih.gov/24649838

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mapping of herpes simplex virus-1 neurovirulence to gamma 134.5, a gene nonessential for growth in culture

1 reference

https://pubmed.ncbi.nlm.nih.gov/24649838

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

ICP34.5 deleted herpes simplex virus with enhanced oncolytic, immune stimulating, and anti-tumour properties

1 reference

https://pubmed.ncbi.nlm.nih.gov/24649838

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Preclinical evaluation of a genetically engineered herpes simplex virus expressing interleukin-12

1 reference

https://pubmed.ncbi.nlm.nih.gov/24649838

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interleukin 12 induces stable priming for interferon gamma (IFN-gamma) production during differentiation of human T helper (Th) cells and transient IFN-gamma production in established Th2 cell clones

1 reference

https://pubmed.ncbi.nlm.nih.gov/24649838

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

An oncolytic viral mutant that delivers the CYP2B1 transgene and augments cyclophosphamide chemotherapy

1 reference

https://pubmed.ncbi.nlm.nih.gov/24649838

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A primer of primate pathology: lesions and nonlesions

1 reference

https://pubmed.ncbi.nlm.nih.gov/24649838

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Toxicity evaluation of replication-competent herpes simplex virus (ICP 34.5 null mutant 1716) in patients with recurrent malignant glioma

1 reference

https://pubmed.ncbi.nlm.nih.gov/24649838

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Experimental herpes simplex infection in the owl monkey.

1 reference

https://pubmed.ncbi.nlm.nih.gov/24649838

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Oncogenes in Ras signalling pathway dictate host-cell permissiveness to herpes simplex virus 1.

1 reference

https://pubmed.ncbi.nlm.nih.gov/24649838

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Herpesvirus vectors for therapy of brain tumors

1 reference

https://pubmed.ncbi.nlm.nih.gov/24649838

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Synergistic anti-tumor responses after administration of agonistic antibodies to CD40 and IL-2: coordination of dendritic and CD8+ cell responses

1 reference

https://pubmed.ncbi.nlm.nih.gov/24649838

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Comparison of genetically engineered herpes simplex viruses for the treatment of brain tumors in a scid mouse model of human malignant glioma

1 reference

https://pubmed.ncbi.nlm.nih.gov/24649838

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Experimental Therapy of Human Glioma by Means of a Genetically Engineered Virus Mutant

1 reference

https://pubmed.ncbi.nlm.nih.gov/24649838

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Engineered herpes simplex virus expressing IL-12 in the treatment of experimental murine brain tumors

1 reference

https://pubmed.ncbi.nlm.nih.gov/24649838

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Therapeutic efficiency and safety of a second-generation replication-conditional HSV1 vector for brain tumor gene therapy.

1 reference

https://pubmed.ncbi.nlm.nih.gov/24649838

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Treatment of intracranial gliomas in immunocompetent mice using herpes simplex viruses that express murine interleukins

1 reference

https://pubmed.ncbi.nlm.nih.gov/24649838

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Current concepts and management of glioblastoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/24649838

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomised phase III study: 5-year analysis of the EORTC-NCIC trial

1 reference

https://pubmed.ncbi.nlm.nih.gov/24649838

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The acute phase response inhibits reverse cholesterol transport

1 reference

https://pubmed.ncbi.nlm.nih.gov/24649838

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of angiogenesis in vivo by interleukin 12.

1 reference

https://pubmed.ncbi.nlm.nih.gov/24649838

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Attenuated, replication-competent herpes simplex virus type 1 mutant G207: safety evaluation of intracerebral injection in nonhuman primates.

1 reference

https://pubmed.ncbi.nlm.nih.gov/24649838

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Imaging and therapy of experimental schwannomas using HSV amplicon vector-encoding apoptotic protein under Schwann cell promoter

1 reference

https://pubmed.ncbi.nlm.nih.gov/24649838

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Exogenous recombinant human IL-12 augments MHC class I antigen expression on human cancer cells in vitro

1 reference

https://pubmed.ncbi.nlm.nih.gov/24649838

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mortality causes of owl monkeys (Aotus nancymae and Aotus vociferans) in captivity

1 reference

https://pubmed.ncbi.nlm.nih.gov/24649838

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Plasmodium vivax under the microscope: the Aotus model

1 reference

https://pubmed.ncbi.nlm.nih.gov/24649838

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Multimodality therapy with a replication-conditional herpes simplex virus 1 mutant that expresses yeast cytosine deaminase for intratumoral conversion of 5-fluorocytosine to 5-fluorouracil.

1 reference

https://pubmed.ncbi.nlm.nih.gov/24649838

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of infection and inflammation on lipid and lipoprotein metabolism: mechanisms and consequences to the host

1 reference

https://pubmed.ncbi.nlm.nih.gov/24649838

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Development of a second-generation oncolytic Herpes simplex virus expressing TNFalpha for cancer therapy

1 reference

https://pubmed.ncbi.nlm.nih.gov/24649838

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of angiogenesis by interleukin-12 is mediated by the interferon-inducible protein 10

1 reference

https://pubmed.ncbi.nlm.nih.gov/24649838

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Enhanced inhibition of syngeneic murine tumors by combinatorial therapy with genetically engineered HSV-1 expressing CCL2 and IL-12.

1 reference

https://pubmed.ncbi.nlm.nih.gov/24649838

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

High level IL-12 production by murine dendritic cells: upregulation via MHC class II and CD40 molecules and downregulation by IL-4 and IL-10.

1 reference

https://pubmed.ncbi.nlm.nih.gov/24649838

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The owl monkey (Aotus trivirgatus) as an animal model for viral diseases and oncologic studies

1 reference

https://pubmed.ncbi.nlm.nih.gov/24649838

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A novel fusogenic herpes simplex virus for oncolytic virotherapy of squamous cell carcinoma.

1 reference

https://pubmed.ncbi.nlm.nih.gov/24649838

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Potent antitumor activity after systemic delivery of a doubly fusogenic oncolytic herpes simplex virus against metastatic prostate cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/24649838

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Engineered herpes simplex virus expressing bacterial cytosine deaminase for experimental therapy of brain tumors

1 reference

https://pubmed.ncbi.nlm.nih.gov/24649838

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In vivo behavior of genetically engineered herpes simplex viruses R7017 and R7020. II. Studies in immunocompetent and immunosuppressed owl monkeys (Aotus trivirgatus)

1 reference

https://pubmed.ncbi.nlm.nih.gov/24649838

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phase Ib trial of mutant herpes simplex virus G207 inoculated pre-and post-tumor resection for recurrent GBM

1 reference

https://pubmed.ncbi.nlm.nih.gov/24649838

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Reduction and elimination of encephalitis in an experimental glioma therapy model with attenuated herpes simplex mutants that retain susceptibility to acyclovir

1 reference

https://pubmed.ncbi.nlm.nih.gov/24649838

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The gamma134.5 protein of herpes simplex virus 1 has the structural and functional attributes of a protein phosphatase 1 regulatory subunit and is present in a high molecular weight complex with the enzyme in infected cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/24649838

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Multimodal cancer treatment mediated by a replicating oncolytic virus that delivers the oxazaphosphorine/rat cytochrome P450 2B1 and ganciclovir/herpes simplex virus thymidine kinase gene therapies

1 reference

https://pubmed.ncbi.nlm.nih.gov/24649838

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Attenuated multi–mutated herpes simplex virus–1 for the treatment of malignant gliomas

1 reference

https://pubmed.ncbi.nlm.nih.gov/24649838

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1089/HUM.2013.201

1 reference

Europe PubMed Central

PubMed publication ID

19 October 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

19 October 2017

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