(Q42288627)

19 October 2017

1 reference

8 February 2021

Interleukin-6/STAT3 signaling as a promising target to improve the efficacy of cancer immunotherapy (English)

1 reference

signal transducer and activator of transcription 3

19 October 2017

1 reference

22 December 2019

1 reference

9 September 2020

1 reference

PubMed publication ID

1 reference

8 February 2021

dendritic cell

1 reference

PubMed publication ID

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28749573%20AND%20SRC:MED&resulttype=core&format=json

6 June 2020

author name string

Yosuke Ohno

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28749573%20AND%20SRC:MED&resulttype=core&format=json

6 June 2020

Yujiro Toyoshima

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28749573%20AND%20SRC:MED&resulttype=core&format=json

6 June 2020

Junya Ohtake

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28749573%20AND%20SRC:MED&resulttype=core&format=json

6 June 2020

Shigenori Homma

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28749573%20AND%20SRC:MED&resulttype=core&format=json

6 June 2020

Hideki Kawamura

6

1 reference

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6 June 2020

Norihiko Takahashi

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28749573%20AND%20SRC:MED&resulttype=core&format=json

6 June 2020

Akinobu Taketomi

8

1 reference

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6 June 2020

language of work or name

1 reference

27 July 2017

1 reference

19 October 2017

1 October 2017

8 references

3 April 2019

25 June 2019

20 November 2019

28 November 2019

22 December 2019

25 August 2020

9 September 2020

8 February 2021

9 references

3 April 2019

25 June 2019

20 November 2019

28 November 2019

22 December 2019

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28749573%20AND%20SRC:MED&resulttype=core&format=json

6 June 2020

25 August 2020

9 September 2020

8 February 2021

108

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28749573%20AND%20SRC:MED&resulttype=core&format=json

6 June 2020

issue

10

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28749573%20AND%20SRC:MED&resulttype=core&format=json

6 June 2020

page(s)

1947-1952

1 reference

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Creative Commons Attribution-NonCommercial

6 June 2020

copyright license

7 references

3 April 2019

25 June 2019

20 November 2019

28 November 2019

22 December 2019

25 August 2020

8 February 2021

on focus list of Wikimedia project

ScienceSource

0 references

cites work

Regulatory T cells in cancer immunotherapy

1 reference

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Peptide vaccines in cancer-old concept revisited

26 October 2017

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The ETS factor ESE3/EHF represses IL-6 preventing STAT3 activation and expansion of the prostate cancer stem-like compartment

26 October 2017

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Biphasic function of TLR3 adjuvant on tumor and spleen dendritic cells promotes tumor T cell infiltration and regression in a vaccine therapy.

26 October 2017

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Recommendations for myeloid-derived suppressor cell nomenclature and characterization standards

26 October 2017

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Interleukin-6 Induced "Acute" Phenotypic Microenvironment Promotes Th1 Anti-Tumor Immunity in Cryo-Thermal Therapy Revealed By Shotgun and Parallel Reaction Monitoring Proteomics.

26 October 2017

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Roles of regulatory T cells in cancer immunity

26 October 2017

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Synergy of TLR3 and 7 ligands significantly enhances function of DCs to present inactivated PRRSV antigen through TRIF/MyD88-NF-κB signaling pathway.

26 October 2017

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Adoptive T-Cell Therapy for Cancer

26 October 2017

1 reference

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Potential therapeutic implications of IL-6/IL-6R/gp130-targeting agents in breast cancer

26 October 2017

1 reference

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IL-6 promotes growth and epithelial-mesenchymal transition of CD133+ cells of non-small cell lung cancer

26 October 2017

1 reference

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A High RORγT/CD3 Ratio is a Strong Prognostic Factor for Postoperative Survival in Advanced Colorectal Cancer: Analysis of Helper T Cell Lymphocytes (Th1, Th2, Th17 and Regulatory T Cells).

26 October 2017

1 reference

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Extent and Location of Tumor-Infiltrating Lymphocytes in Microsatellite-Stable Colon Cancer Predict Outcome to Adjuvant Active Specific Immunotherapy

26 October 2017

1 reference

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Interferon-γ-induced activation of JAK1 and JAK2 suppresses tumor cell susceptibility to NK cells through upregulation of PD-L1 expression

26 October 2017

1 reference

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IFN-γ from lymphocytes induces PD-L1 expression and promotes progression of ovarian cancer.

26 October 2017

1 reference

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IL-6-mediated environmental conditioning of defective Th1 differentiation dampens antitumour immune responses in old age.

26 October 2017

1 reference

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A phase 2, randomized, double-blind, placebo-controlled study of siltuximab (anti-IL-6 mAb) and bortezomib versus bortezomib alone in patients with relapsed or refractory multiple myeloma.

26 October 2017

1 reference

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STAT1 drives tumor progression in serous papillary endometrial cancer.

26 October 2017

1 reference

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The intratumoural subsite and relation of CD8(+) and FOXP3(+) T lymphocytes in colorectal cancer provide important prognostic clues

26 October 2017

1 reference

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A phase I/II, multiple-dose, dose-escalation study of siltuximab, an anti-interleukin-6 monoclonal antibody, in patients with advanced solid tumors

26 October 2017

1 reference

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Tumour antigens recognized by T lymphocytes: at the core of cancer immunotherapy

26 October 2017

1 reference

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Evaluation of the QTc prolongation potential of a monoclonal antibody, siltuximab, in patients with monoclonal gammopathy of undetermined significance, smoldering multiple myeloma, or low-volume multiple myeloma

26 October 2017

1 reference

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Dendritic-cell-based therapeutic cancer vaccines

26 October 2017

1 reference

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Nivolumab plus ipilimumab in advanced melanoma

26 October 2017

1 reference

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Melanoma-educated CD14+ cells acquire a myeloid-derived suppressor cell phenotype through COX-2-dependent mechanisms

26 October 2017

1 reference

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Serum levels of IL-6 and IL-1β can predict the efficacy of gemcitabine in patients with advanced pancreatic cancer

26 October 2017

1 reference

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Personalized peptide vaccination for advanced biliary tract cancer: IL-6, nutritional status and pre-existing antigen-specific immunity as possible biomarkers for patient prognosis

26 October 2017

1 reference

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Safety and Activity of Anti–PD-L1 Antibody in Patients with Advanced Cancer

26 October 2017

1 reference

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Cancer immunotherapy via dendritic cells

26 October 2017

1 reference

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Positive feedback between PGE2 and COX2 redirects the differentiation of human dendritic cells toward stable myeloid-derived suppressor cells.

26 October 2017

1 reference

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IL-6 trans-signaling licenses mouse and human tumor microvascular gateways for trafficking of cytotoxic T cells

26 October 2017

1 reference

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The anti-interleukin-6 antibody siltuximab down-regulates genes implicated in tumorigenesis in prostate cancer patients from a phase I study

26 October 2017

1 reference

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A phase I/II study of siltuximab (CNTO 328), an anti-interleukin-6 monoclonal antibody, in metastatic renal cell cancer

26 October 2017

1 reference

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Improved Survival with Ipilimumab in Patients with Metastatic Melanoma

26 October 2017

1 reference

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Pharmacokinetic and pharmacodynamic modeling of an anti-interleukin-6 chimeric monoclonal antibody (siltuximab) in patients with metastatic renal cell carcinoma

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5623748

Serum interleukin-6 levels in colorectal cancer patients--a summary of published results

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5623748

Identification of novel helper epitopes of MAGE-A4 tumour antigen: useful tool for the propagation of Th1 cells

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5623748

Regulation of the IL-23 and IL-12 balance by Stat3 signaling in the tumor microenvironment

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5623748

Treatment of metastatic melanoma with autologous CD4+ T cells against NY-ESO-1

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5623748

Taking dendritic cells into medicine

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5623748

IL-23 promotes tumour incidence and growth

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5623748

Immunotherapy: bewitched, bothered, and bewildered no more

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5623748

STAT4 serine phosphorylation is critical for IL-12-induced IFN-gamma production but not for cell proliferation

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5623748

Roles of STAT3 in mediating the cell growth, differentiation and survival signals relayed through the IL-6 family of cytokine receptors

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5623748

Distinct role of antigen-specific T helper type 1 (Th1) and Th2 cells in tumor eradication in vivo

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5623748

Development of TH1 CD4+ T cells through IL-12 produced by Listeria-induced macrophages

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5623748

Complementary DNA for a novel human interleukin (BSF-2) that induces B lymphocytes to produce immunoglobulin

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5623748

A Gene Encoding an Antigen Recognized by Cytolytic T Lymphocytes on a Human Melanoma

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5623748

Randomised phase II study of siltuximab (CNTO 328), an anti-IL-6 monoclonal antibody, in combination with mitoxantrone/prednisone versus mitoxantrone/prednisone alone in metastatic castration-resistant prostate cancer

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5623748

IL-11 induces differentiation of myeloid-derived suppressor cells through activation of STAT3 signalling pathway

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5623748

A TLR3-Specific Adjuvant Relieves Innate Resistance to PD-L1 Blockade without Cytokine Toxicity in Tumor Vaccine Immunotherapy.

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5623748

Soluble IL6R Expressed by Myeloid Cells Reduces Tumor-Specific Th1 Differentiation and Drives Tumor Progression.

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5623748

Chemotherapeutic effects of luteolin on radio-sensitivity enhancement and interleukin-6/signal transducer and activator of transcription 3 signaling repression of oral cancer stem cells.

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5623748

IL-6 down-regulates HLA class II expression and IL-12 production of human dendritic cells to impair activation of antigen-specific CD4(+) T cells.

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5623748

A phase I trial combining carboplatin/doxorubicin with tocilizumab, an anti-IL-6R monoclonal antibody, and interferon-α2b in patients with recurrent epithelial ovarian cancer.

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5623748

Predictive biomarkers for the outcome of vaccination of five therapeutic epitope peptides for colorectal cancer.

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5623748

Identification of novel helper epitope peptides of Survivin cancer-associated antigen applicable to developing helper/killer-hybrid epitope long peptide cancer vaccine

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5623748

Increased CD14(+)HLA-DR (-/low) myeloid-derived suppressor cells correlate with extrathoracic metastasis and poor response to chemotherapy in non-small cell lung cancer patients.

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5623748

Soluble interleukin-6 receptor is a serum biomarker for the response of esophageal carcinoma to neoadjuvant chemoradiotherapy.

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5623748

A phase 2 multicentre study of siltuximab, an anti-interleukin-6 monoclonal antibody, in patients with relapsed or refractory multiple myeloma

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5623748

The key role of IL-6-arginase cascade for inducing dendritic cell-dependent CD4(+) T cell dysfunction in tumor-bearing mice

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5623748

Immunosuppressive CD14+HLA-DR(low)/- monocytes in B-cell non-Hodgkin lymphoma

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5623748

IL-6 regulates in vivo dendritic cell differentiation through STAT3 activation.

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5623748

STAT3 regulates NF-kappaB recruitment to the IL-12p40 promoter in dendritic cells.

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5623748

IL-6-STAT3 controls intracellular MHC class II alphabeta dimer level through cathepsin S activity in dendritic cells

17 August 2018

1 reference

12 December 2020

First clinical trial of cancer vaccine therapy with artificially synthesized helper/ killer-hybrid epitope long peptide of MAGE-A4 cancer antigen

1 reference

12 December 2020

Anti-IL-6 receptor mAb eliminates myeloid-derived suppressor cells and inhibits tumor growth by enhancing T-cell responses

1 reference

12 December 2020

Effect of standard anthracycline based neoadjuvant chemotherapy on circulating levels of serum IL-6 in patients of locally advanced carcinoma breast - a prospective study

1 reference

12 December 2020

Clinical impact of tumor-infiltrating lymphocytes for survival in curatively resected stage IV colon cancer with isolated liver or lung metastasis

1 reference

12 December 2020

Myeloid-derived suppressor cells attenuate TH1 development through IL-6 production to promote tumor progression

1 reference

12 December 2020

Identifiers

DOI

10.1111/CAS.13332

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28749573%20AND%20SRC:MED&resulttype=core&format=json

6 June 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28749573%20AND%20SRC:MED&resulttype=core&format=json

6 June 2020

PubMed publication ID

28749573

1 reference