(Q39617919)

13 September 2017

IL-6-mediated environmental conditioning of defective Th1 differentiation dampens antitumour immune responses in old age. (English)

1 reference

13 September 2017

4

Susan L Swain

1 reference

13 September 2017

Hirotake Tsukamoto

1

1 reference

13 September 2017

Satoru Senju

series ordinal

2

1 reference

13 September 2017

Keiko Matsumura

series ordinal

3

1 reference

13 September 2017

Yasuharu Nishimura

series ordinal

5

1 reference

13 September 2017

language of work or name

English

0 references

publication date

7 April 2015

1 reference

13 September 2017

Nature Communications

1 reference

13 September 2017

6

1 reference

13 September 2017

6702

1 reference

Creative Commons Attribution 4.0 International

13 September 2017

start time

7 April 2015

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

exact match

https://scigraph.springernature.com/pub.10.1038/ncomms7702

0 references

cites work

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Curcumin improves the therapeutic efficacy of Listeria(at)-Mage-b vaccine in correlation with improved T-cell responses in blood of a triple-negative breast cancer model 4T1.

14 September 2017

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Tumor-specific CD4+ T cells maintain effector and memory tumor-specific CD8+ T cells

14 September 2017

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Aging predisposes to acute inflammatory induced pathology after tumor immunotherapy

14 September 2017

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How ageing processes influence cancer

14 September 2017

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Understanding immunosenescence to improve responses to vaccines

14 September 2017

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Chimeric antigen receptor-modified T cells for acute lymphoid leukemia

14 September 2017

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Targeting tumor-infiltrating macrophages decreases tumor-initiating cells, relieves immunosuppression, and improves chemotherapeutic responses

14 September 2017

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CXCR3 chemokine receptor-ligand interactions in the lymph node optimize CD4+ T helper 1 cell differentiation

14 September 2017

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The aged microenvironment contributes to the age-related functional defects of CD4 T cells in mice

14 September 2017

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Mitigating age-related immune dysfunction heightens the efficacy of tumor immunotherapy in aged mice.

14 September 2017

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Adoptive immunotherapy for cancer: harnessing the T cell response

14 September 2017

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The immune contexture in human tumours: impact on clinical outcome

14 September 2017

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Interleukin-6 as a therapeutic target in human ovarian cancer

14 September 2017

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Inflammation driven by tumour-specific Th1 cells protects against B-cell cancer

14 September 2017

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Bim dictates naive CD4 T cell lifespan and the development of age-associated functional defects

14 September 2017

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Cell-intrinsic defects in the proliferative response of antiviral memory CD8 T cells in aged mice upon secondary infection

14 September 2017

1 reference

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Naive tumor-specific CD4(+) T cells differentiated in vivo eradicate established melanoma.

14 September 2017

1 reference

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CD8(+) T lymphocyte mobilization to virus-infected tissue requires CD4(+) T-cell help

14 September 2017

1 reference

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Serum and muscle interleukin-15 levels decrease in aging mice: correlation with declines in soluble interleukin-15 receptor alpha expression

14 September 2017

1 reference

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Age-associated increase in lifespan of naive CD4 T cells contributes to T-cell homeostasis but facilitates development of functional defects

14 September 2017

1 reference

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Changes in IL-15 expression and death-receptor apoptotic signaling in rat gastrocnemius muscle with aging and life-long calorie restriction

14 September 2017

1 reference

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Molecular inflammation: underpinnings of aging and age-related diseases

14 September 2017

1 reference

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Inflammation, ageing and cancer.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4396369

Functional regulatory T cells accumulate in aged hosts and promote chronic infectious disease reactivation

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4396369

Treatment of metastatic melanoma with autologous CD4+ T cells against NY-ESO-1

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4396369

Aging up-regulates expression of inflammatory mediators in mouse adipose tissue

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4396369

Synergy of IL-21 and IL-15 in regulating CD8+ T cell expansion and function.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4396369

A dominant mutation within the DNA-binding domain of the bZIP transcription factor Maf causes murine cataract and results in selective alteration in DNA binding

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4396369

Disease-associated bias in T helper type 1 (Th1)/Th2 CD4(+) T cell responses against MAGE-6 in HLA-DRB10401(+) patients with renal cell carcinoma or melanoma

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4396369

Transcription: tantalizing times for T cells

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4396369

Interleukin 2, but not other common gamma chain-binding cytokines, can reverse the defect in generation of CD4 effector T cells from naive T cells of aged mice

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4396369

c-maf promotes T helper cell type 2 (Th2) and attenuates Th1 differentiation by both interleukin 4-dependent and -independent mechanisms

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4396369

The function of the soluble interleukin 6 (IL-6) receptor in vivo: sensitization of human soluble IL-6 receptor transgenic mice towards IL-6 and prolongation of the plasma half-life of IL-6.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4396369

IL-6 plays a unique role in initiating c-Maf expression during early stage of CD4 T cell activation.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4396369

Enhanced priming of antigen-specific CTLs in vivo by embryonic stem cell-derived dendritic cells expressing chemokine along with antigenic protein: application to antitumor vaccination

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4396369

IFN-γ from CD4 T cells is essential for host survival and enhances CD8 T cell function during Mycobacterium tuberculosis infection.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4396369

CD4+ T-cell help in the tumor milieu is required for recruitment and cytolytic function of CD8+ T lymphocytes

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4396369

Altered Th1/Th2 commitment in human CD4+ T cells with ageing.

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4396369

Specific T helper cell requirement for optimal induction of cytotoxic T lymphocytes against major histocompatibility complex class II negative tumors

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4396369

Lymphocyte subsets and natural killer cell activity in healthy old people and centenarians.

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4396369

Immune-escape markers in relation to clinical outcome of advanced melanoma patients following immunotherapy.

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4396369

T-helper-1-cell cytokines drive cancer into senescence

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4396369

Cancer-Associated Fibroblasts Are Activated in Incipient Neoplasia to Orchestrate Tumor-Promoting Inflammation in an NF-kappaB-Dependent Manner.

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4396369

Age-dependent modifications of Type 1 and Type 2 cytokines within virgin and memory CD4+ T cells in humans.

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4396369

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4396369

Early antigen-specific response by naive CD8 T cells is not altered with aging.

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4396369

21 August 2018

Eosinophils and cancer.

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FNCOMMS7702

Inhibition of Th1 Differentiation by IL-6 Is Mediated by SOCS1

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FNCOMMS7702

c-Maf activates the promoter and enhancer of the IL-21 gene, and TGF-β inhibits c-Maf-induced IL-21 production in CD4+ T cells

21 January 2018

1 reference

12 December 2020

Myeloid-derived suppressor cells attenuate TH1 development through IL-6 production to promote tumor progression

1 reference

12 December 2020

No intrinsic deficiencies in CD8+ T cell-mediated antitumor immunity with aging

1 reference

12 December 2020

Targeting antigen into the phagocytic pathway in vivo induces protective tumour immunity

1 reference

12 December 2020

Suppression of concanavalin A-induced hepatitis in IFN-gamma(-/-) mice, but not in TNF-alpha(-/-) mice: role for IFN-gamma in activating apoptosis of hepatocytes

1 reference

12 December 2020

The origins of age-related proinflammatory state

1 reference

12 December 2020

Identifiers

DOI

10.1038/NCOMMS7702

1 reference

Dimensions Publication ID

13 September 2017

0 references

0 references

1 reference

13 September 2017

PubMed publication ID

25850032

1 reference