(Q42325394)

English

The arginine of the DRY motif in transmembrane segment III functions as a balancing micro-switch in the activation of the β2-adrenergic receptor

scientific article published on 26 July 2012

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

26 October 2017

The arginine of the DRY motif in transmembrane segment III functions as a balancing micro-switch in the activation of the β2-adrenergic receptor (English)

1 reference

Europe PubMed Central

PMC publication ID

26 October 2017

transmembrane protein

0 references

Nicholas D. Holliday

5

1 reference

Europe PubMed Central

PMC publication ID

26 October 2017

Thue W Schwartz

object named as

Thue W Schwartz

6

0 references

author name string

Louise Valentin-Hansen

1

1 reference

Europe PubMed Central

PMC publication ID

26 October 2017

Marleen Groenen

2

1 reference

Europe PubMed Central

PMC publication ID

26 October 2017

Rie Nygaard

3

1 reference

Europe PubMed Central

PMC publication ID

26 October 2017

Thomas M Frimurer

4

1 reference

Europe PubMed Central

PMC publication ID

26 October 2017

language of work or name

0 references

publication date

26 July 2012

1 reference

Europe PubMed Central

PMC publication ID

26 October 2017

Journal of Biological Chemistry

1 reference

Europe PubMed Central

PMC publication ID

26 October 2017

287

1 reference

Europe PubMed Central

PMC publication ID

26 October 2017

38

1 reference

Europe PubMed Central

PMC publication ID

26 October 2017

31973-31982

1 reference

Europe PubMed Central

PMC publication ID

26 October 2017

Crystal structure of the β2 adrenergic receptor-Gs protein complex

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3442529

29 May 2018

Structure of an agonist-bound human A2A adenosine receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3442529

29 May 2018

Crystal structure of metarhodopsin II

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3442529

29 May 2018

Structure of a nanobody-stabilized active state of the β(2) adrenoceptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3442529

29 May 2018

Highly conserved tyrosine stabilizes the active state of rhodopsin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3442529

29 May 2018

Conserved water-mediated hydrogen bond network between TM-I, -II, -VI, and -VII in 7TM receptor activation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3442529

29 May 2018

A conserved aromatic lock for the tryptophan rotameric switch in TM-VI of seven-transmembrane receptors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3442529

29 May 2018

Ligand binding and micro-switches in 7TM receptor structures

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3442529

29 May 2018

Identification of two distinct inactive conformations of the beta2-adrenergic receptor reconciles structural and biochemical observations

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3442529

29 May 2018

The 2.6 angstrom crystal structure of a human A2A adenosine receptor bound to an antagonist

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3442529

29 May 2018

Crystal structure of opsin in its G-protein-interacting conformation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3442529

29 May 2018

Dual role of the beta2-adrenergic receptor C terminus for the binding of beta-arrestin and receptor internalization

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3442529

29 May 2018

High-resolution crystal structure of an engineered human beta2-adrenergic G protein-coupled receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3442529

29 May 2018

GPCR engineering yields high-resolution structural insights into beta2-adrenergic receptor function

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3442529

29 May 2018

Crystal structure of the human beta2 adrenergic G-protein-coupled receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3442529

29 May 2018

The highly conserved DRY motif of class A G protein-coupled receptors: beyond the ground state.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3442529

29 May 2018

Molecular mechanism of 7TM receptor activation--a global toggle switch model

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3442529

29 May 2018

A beta-arrestin binding determinant common to the second intracellular loops of rhodopsin family G protein-coupled receptors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3442529

29 May 2018

A GPCR that is not "DRY".

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3442529

29 May 2018

High constitutive activity of a virus-encoded seven transmembrane receptor in the absence of the conserved DRY motif (Asp-Arg-Tyr) in transmembrane helix 3.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3442529

29 May 2018

Rhodopsin structure, dynamics, and activation: a perspective from crystallography, site-directed spin labeling, sulfhydryl reactivity, and disulfide cross-linking

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3442529

29 May 2018

Sequence analyses of G-protein-coupled receptors: similarities to rhodopsin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3442529

29 May 2018

Development and current status of the CHARMM force field for nucleic acids.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3442529

29 May 2018

Activation of the beta 2-adrenergic receptor involves disruption of an ionic lock between the cytoplasmic ends of transmembrane segments 3 and 6.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3442529

29 May 2018

Crystal structure of rhodopsin: A G protein-coupled receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3442529

29 May 2018

Mutation of a highly conserved aspartic acid in the beta2 adrenergic receptor: constitutive activation, structural instability, and conformational rearrangement of transmembrane segment 6.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3442529

29 May 2018

Constitutively active alpha-1b adrenergic receptor mutants display different phosphorylation and internalization features

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3442529

29 May 2018

Mutations of the DRY motif that preserve beta 2-adrenoceptor coupling.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3442529

29 May 2018

Conserved Tyr223(5.58) plays different roles in the activation and G-protein interaction of rhodopsin.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3442529

17 August 2018

Impact of the DRY motif and the missing "ionic lock" on constitutive activity and G-protein coupling of the human histamine H4 receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3442529

17 August 2018

Functional role of the "ionic lock"--an interhelical hydrogen-bond network in family A heptahelical receptors.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3442529

17 August 2018

Development of a BRET2 screening assay using beta-arrestin 2 mutants

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3442529

17 August 2018

Steric hindrance mutagenesis versus alanine scan in mapping of ligand binding sites in the tachykinin NK1 receptor.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3442529

17 August 2018

A key role for transmembrane prolines in calcitonin receptor-like receptor agonist binding and signalling: implications for family B G-protein-coupled receptors.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M112.348565

21 January 2018

Conformational compatibility as a basis of differential affinities of tachykinins for the neurokinin-1 receptor

1 reference

https://pubmed.ncbi.nlm.nih.gov/22843684

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mutations of the conserved DRS motif in the second intracellular loop of the gonadotropin-releasing hormone receptor affect expression, activation, and internalization

1 reference

https://pubmed.ncbi.nlm.nih.gov/22843684

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Bioluminescence resonance energy transfer as a screening assay: Focus on partial and inverse agonism

1 reference

https://pubmed.ncbi.nlm.nih.gov/22843684

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1074/JBC.M112.348565

1 reference

Europe PubMed Central

PMC publication ID

26 October 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

26 October 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

26 October 2017

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