(Q42376602)

English

The selective Aurora-A kinase inhibitor MLN8237 (alisertib) potently inhibits proliferation of glioblastoma neurosphere tumor stem-like cells and potentiates the effects of temozolomide and ionizing radiation

scientific article published on 14 March 2014

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

28 October 2017

The selective Aurora-A kinase inhibitor MLN8237 (alisertib) potently inhibits proliferation of glioblastoma neurosphere tumor stem-like cells and potentiates the effects of temozolomide and ionizing radiation (English)

1 reference

Europe PubMed Central

PMC publication ID

28 October 2017

0 references

1 reference

based on heuristic

inferred from title

Ana C. deCarvalho

7

1 reference

Europe PubMed Central

PMC publication ID

28 October 2017

Norman L. Lehman

11

1 reference

Europe PubMed Central

PMC publication ID

28 October 2017

10

object named as

Tom Mikkelsen

1 reference

Europe PubMed Central

PMC publication ID

28 October 2017

author name string

Xin Hong

1

1 reference

Europe PubMed Central

PMC publication ID

28 October 2017

James P O'Donnell

2

1 reference

Europe PubMed Central

PMC publication ID

28 October 2017

Clarence R Salazar

3

1 reference

Europe PubMed Central

PMC publication ID

28 October 2017

James R Van Brocklyn

4

1 reference

Europe PubMed Central

PMC publication ID

28 October 2017

Kahlil D Barnett

5

1 reference

Europe PubMed Central

PMC publication ID

28 October 2017

Dennis K Pearl

6

1 reference

Europe PubMed Central

PMC publication ID

28 October 2017

Jeffrey A Ecsedy

8

1 reference

Europe PubMed Central

PMC publication ID

28 October 2017

Stephen L Brown

9

1 reference

Europe PubMed Central

PMC publication ID

28 October 2017

publication date

14 March 2014

1 reference

Europe PubMed Central

PMC publication ID

28 October 2017

Cancer Chemotherapy and Pharmacology

1 reference

Europe PubMed Central

PMC publication ID

28 October 2017

73

1 reference

Europe PubMed Central

PMC publication ID

28 October 2017

5

1 reference

Europe PubMed Central

PMC publication ID

28 October 2017

983-990

1 reference

Europe PubMed Central

PMC publication ID

28 October 2017

https://scigraph.springernature.com/pub.10.1007/s00280-014-2430-z

0 references

Aurora A is differentially expressed in gliomas, is associated with patient survival in glioblastoma and is a potential chemotherapeutic target in gliomas

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4975936

28 May 2018

Targeting Aurora Kinase A enhances radiation sensitivity of atypical teratoid rhabdoid tumor cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4975936

28 May 2018

Inhibition of Aurora kinases enhances chemosensitivity to temozolomide and causes radiosensitization in glioblastoma cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4975936

28 May 2018

Characterization of Alisertib (MLN8237), an investigational small-molecule inhibitor of aurora A kinase using novel in vivo pharmacodynamic assays

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4975936

28 May 2018

Efficacy and pharmacokinetic/pharmacodynamic evaluation of the Aurora kinase A inhibitor MLN8237 against preclinical models of pediatric cancer.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4975936

28 May 2018

The novel Aurora A kinase inhibitor MLN8237 is active in resistant chronic myeloid leukaemia and significantly increases the efficacy of nilotinib

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4975936

28 May 2018

Suppression of Aurora-A oncogenic potential by c-Myc downregulation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4975936

28 May 2018

The Aurora-A/TPX2 complex: a novel oncogenic holoenzyme?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4975936

28 May 2018

A novel Aurora-A kinase inhibitor MLN8237 induces cytotoxicity and cell-cycle arrest in multiple myeloma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4975936

28 May 2018

MLN8054, an inhibitor of Aurora A kinase, induces senescence in human tumor cells both in vitro and in vivo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4975936

28 May 2018

Gliosarcoma stem cells undergo glial and mesenchymal differentiation in vivo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4975936

28 May 2018

Stabilization of N-Myc is a critical function of Aurora A in human neuroblastoma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4975936

28 May 2018

Aurora-A interacts with Cyclin B1 and enhances its stability

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4975936

28 May 2018

Bora and the kinase Aurora a cooperatively activate the kinase Plk1 and control mitotic entry

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4975936

28 May 2018

AIP regulates stability of Aurora-A at early mitotic phase coordinately with GSK-3beta.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4975936

28 May 2018

Aurora-A kinase interacting protein 1 (AURKAIP1) promotes Aurora-A degradation through an alternative ubiquitin-independent pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4975936

28 May 2018

Tumor stem cells derived from glioblastomas cultured in bFGF and EGF more closely mirror the phenotype and genotype of primary tumors than do serum-cultured cell lines

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4975936

28 May 2018

Over-expression of Aurora-A targets cytoplasmic polyadenylation element binding protein and promotes mRNA polyadenylation of Cdk1 and cyclin B1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4975936

28 May 2018

Isolation and characterization of tumorigenic, stem-like neural precursors from human glioblastoma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4975936

28 May 2018

Aurora-A Kinase Maintains the Fidelity of Early and Late Mitotic Events in HeLa Cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4975936

28 May 2018

Tumour amplified kinase STK15/BTAK induces centrosome amplification, aneuploidy and transformation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4975936

28 May 2018

Phase I study of aurora A kinase inhibitor MLN8237 in advanced solid tumors: safety, pharmacokinetics, pharmacodynamics, and bioavailability of two oral formulations

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4975936

16 August 2018

Isolation of cancer stem cells from adult glioblastoma multiforme

1 reference

https://pubmed.ncbi.nlm.nih.gov/24627220

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1007/S00280-014-2430-Z

1 reference

Europe PubMed Central

PMC publication ID

28 October 2017

Dimensions Publication ID

0 references

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

28 October 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

28 October 2017

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