(Q42413520)

English

The peroxisome proliferator-activated receptor γ (PPARγ) controls natural protective mechanisms against lipid peroxidation in amyotrophic lateral sclerosis

scientific article published on 21 August 2012

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scholarly article

1 reference

Europe PubMed Central

30 October 2017

The peroxisome proliferator-activated receptor γ (PPARγ) controls natural protective mechanisms against lipid peroxidation in amyotrophic lateral sclerosis (English)

1 reference

Europe PubMed Central

30 October 2017

amyotrophic lateral sclerosis

0 references

Liliana Brambilla

3

1 reference

Europe PubMed Central

30 October 2017

5

1 reference

Europe PubMed Central

30 October 2017

Francesca Martorana

object named as

Francesca Martorana

2

0 references

Valeria Benedusi

object named as

Valeria Benedusi

1

0 references

object named as

Adriana Maggi

4

0 references

language of work or name

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publication date

21 August 2012

1 reference

Europe PubMed Central

30 October 2017

number of pages

13

1 reference

based on heuristic

inferred from page(s)

Journal of Biological Chemistry

1 reference

Europe PubMed Central

30 October 2017

287

1 reference

Europe PubMed Central

30 October 2017

43

1 reference

Europe PubMed Central

30 October 2017

35899-35911

1 reference

Europe PubMed Central

30 October 2017

describes a project that uses

1 reference

Europe PubMed Central

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3476258/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

Mutant SOD1G93A triggers mitochondrial fragmentation in spinal cord motor neurons: neuroprotection by SIRT3 and PGC-1α.

1 reference

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Dietary restriction attenuates age-associated muscle atrophy by lowering oxidative stress in mice even in complete absence of CuZnSOD.

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1 reference

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1 reference

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Striking denervation of neuromuscular junctions without lumbar motoneuron loss in geriatric mouse muscle.

1 reference

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Peroxisome proliferator activator receptor gamma coactivator-1alpha (PGC-1α) improves motor performance and survival in a mouse model of amyotrophic lateral sclerosis

1 reference

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Amyotrophic lateral sclerosis is associated with hypolipidemia at the presymptomatic stage in mice

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The natural protective mechanism against hyperglycemia in vascular endothelial cells: roles of the lipid peroxidation product 4-hydroxydodecadienal and peroxisome proliferator-activated receptor delta

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Increased superoxide in vivo accelerates age-associated muscle atrophy through mitochondrial dysfunction and neuromuscular junction degeneration

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Lipid oxidation and peroxidation in CNS health and disease: from molecular mechanisms to therapeutic opportunities

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Structural basis for the activation of PPARgamma by oxidized fatty acids

1 reference

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Focal degeneration of astrocytes in amyotrophic lateral sclerosis.

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Drug insight: effects mediated by peroxisome proliferator-activated receptor-gamma in CNS disorders

1 reference

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PPARs in the brain

1 reference

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Increased peripheral lipid clearance in an animal model of amyotrophic lateral sclerosis

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PPARs and molecular mechanisms of transrepression

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Evidence for defective energy homeostasis in amyotrophic lateral sclerosis: benefit of a high-energy diet in a transgenic mouse model

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28 May 2018

Oxidative Stress: a common denominator in the pathogenesis of amyotrophic lateral sclerosis.

1 reference

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Muscle-specific PPARgamma-deficient mice develop increased adiposity and insulin resistance but respond to thiazolidinediones

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4-Hydroxy-2-nonenal: a product and mediator of oxidative stress

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Analysis of the cytosolic proteome in a cell culture model of familial amyotrophic lateral sclerosis reveals alterations to the proteasome, antioxidant defenses, and nitric oxide synthetic pathways

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Peroxisome proliferator-activated receptor beta regulates acyl-CoA synthetase 2 in reaggregated rat brain cell cultures

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The lipid peroxidation product 4-hydroxynonenal impairs glutamate and glucose transport and choline acetyltransferase activity in NSC-19 motor neuron cells

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Presence of 4-hydroxynonenal in cerebrospinal fluid of patients with sporadic amyotrophic lateral sclerosis

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ALS-linked SOD1 mutant G85R mediates damage to astrocytes and promotes rapidly progressive disease with SOD1-containing inclusions.

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Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis

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Patients with elevated triglyceride and cholesterol serum levels have a prolonged survival in amyotrophic lateral sclerosis.

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Differential expression and alternative splicing of genes in lumbar spinal cord of an amyotrophic lateral sclerosis mouse model.

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The oral antidiabetic pioglitazone protects from neurodegeneration and amyotrophic lateral sclerosis-like symptoms in superoxide dismutase-G93A transgenic mice.

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Sublethal dose of 4-hydroxynonenal reduces intracellular calcium in surviving motor neurons in vivo

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Accumulation of protein-bound 4-hydroxy-2-hexenal in spinal cords from patients with sporadic amyotrophic lateral sclerosis

1 reference

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Increased lipid peroxidation in sera of ALS patients: a potential biomarker of disease burden

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Evidence that accumulation of ceramides and cholesterol esters mediates oxidative stress-induced death of motor neurons in amyotrophic lateral sclerosis

1 reference

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The peroxisome proliferator-activated receptor alpha-selective activator ciprofibrate upregulates expression of genes encoding fatty acid oxidation and ketogenesis enzymes in rat brain

1 reference

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16 August 2018

An adverse property of a familial ALS-linked SOD1 mutation causes motor neuron disease characterized by vacuolar degeneration of mitochondria

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M112.366419

21 January 2018

Protein modification by the lipid peroxidation product 4-hydroxynonenal in the spinal cords of amyotrophic lateral sclerosis patients

1 reference

https://pubmed.ncbi.nlm.nih.gov/22910911

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Denervation-induced skeletal muscle atrophy is associated with increased mitochondrial ROS production

1 reference

https://pubmed.ncbi.nlm.nih.gov/22910911

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dyslipidemia is a protective factor in amyotrophic lateral sclerosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/22910911

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

An animal model of oral dysphagia in amyotrophic lateral sclerosis.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22910911

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

PGC-1α protects neurons and alters disease progression in an amyotrophic lateral sclerosis mouse model

1 reference

https://pubmed.ncbi.nlm.nih.gov/22910911

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Background and gender effects on survival in the TgN(SOD1-G93A)1Gur mouse model of ALS

1 reference

https://pubmed.ncbi.nlm.nih.gov/22910911

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Monitoring systemic oxidative stress in an animal model of amyotrophic lateral sclerosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/22910911

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Skeletal Muscle Is a Primary Target of SOD1G93A-Mediated Toxicity

1 reference

https://pubmed.ncbi.nlm.nih.gov/22910911

12 December 2020

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inferred from PubMed ID database lookup

A controlled trial of riluzole in amyotrophic lateral sclerosis. ALS/Riluzole Study Group

1 reference

https://pubmed.ncbi.nlm.nih.gov/22910911

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1074/JBC.M112.366419

1 reference

Europe PubMed Central

30 October 2017

1 reference

Europe PubMed Central

30 October 2017

1 reference

Europe PubMed Central

30 October 2017

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