(Q42420033)

English

Molecular basis of the selectivity of the immunoproteasome catalytic subunit LMP2-specific inhibitor revealed by molecular modeling and dynamics simulations.

scientific article published on September 2010

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20812720%20AND%20SRC:MED&resulttype=core&format=json

13 February 2020

Molecular basis of the selectivity of the immunoproteasome catalytic subunit LMP2-specific inhibitor revealed by molecular modeling and dynamics simulations (English)

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20812720%20AND%20SRC:MED&resulttype=core&format=json

13 February 2020

immunoproteasome

1 reference

based on heuristic

inferred from title

Mohamed Diwan M AbdulHameed

2

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20812720%20AND%20SRC:MED&resulttype=core&format=json

13 February 2020

author name string

Beilei Lei

1

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20812720%20AND%20SRC:MED&resulttype=core&format=json

13 February 2020

Adel Hamza

3

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20812720%20AND%20SRC:MED&resulttype=core&format=json

13 February 2020

Marie Wehenkel

4

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20812720%20AND%20SRC:MED&resulttype=core&format=json

13 February 2020

Jennifer L Muzyka

5

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20812720%20AND%20SRC:MED&resulttype=core&format=json

13 February 2020

Xiao-Jun Yao

6

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20812720%20AND%20SRC:MED&resulttype=core&format=json

13 February 2020

Kyung-Bo Kim

7

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20812720%20AND%20SRC:MED&resulttype=core&format=json

13 February 2020

Chang-Guo Zhan

8

1 reference

Europe PubMed Central

PMC publication ID

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13 February 2020

language of work or name

0 references

publication date

1 September 2010

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Europe PubMed Central

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13 February 2020

number of pages

7

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based on heuristic

inferred from page(s)

Journal of Physical Chemistry B

1 reference

Europe PubMed Central

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13 February 2020

114

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13 February 2020

38

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20812720%20AND%20SRC:MED&resulttype=core&format=json

13 February 2020

12333-12339

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20812720%20AND%20SRC:MED&resulttype=core&format=json

13 February 2020

describes a project that uses

molecular modelling

1 reference

based on heuristic

inferred from title

Understanding microscopic binding of human microsomal prostaglandin E synthase-1 (mPGES-1) trimer with substrate PGH2 and cofactor GSH: insights from computational alanine scanning and site-directed mutagenesis

1 reference

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28 May 2018

Selective inhibition of chymotrypsin-like activity of the immunoproteasome and constitutive proteasome in Waldenstrom macroglobulinemia

1 reference

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28 May 2018

Reaction pathway and free-energy barrier for reactivation of dimethylphosphoryl-inhibited human acetylcholinesterase

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28 May 2018

Mechanism for cocaine blocking the transport of dopamine: insights from molecular modeling and dynamics simulations

1 reference

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28 May 2018

Fundamental reaction mechanism and free energy profile for (-)-cocaine hydrolysis catalyzed by cocaine esterase

1 reference

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Design and synthesis of an orally bioavailable and selective peptide epoxyketone proteasome inhibitor (PR-047).

1 reference

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28 May 2018

Catalytic mechanism and assembly of the proteasome.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2945215

28 May 2018

Targeted inhibition of the immunoproteasome is a potent strategy against models of multiple myeloma that overcomes resistance to conventional drugs and nonspecific proteasome inhibitors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2945215

28 May 2018

Proteasome modulators: essential chemical genetic tools for understanding human diseases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2945215

28 May 2018

Modeling the catalysis of anti-cocaine catalytic antibody: competing reaction pathways and free energy barriers

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2945215

28 May 2018

LMP2-specific inhibitors: chemical genetic tools for proteasome biology

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2945215

28 May 2018

20S proteasome and its inhibitors: crystallographic knowledge for drug development

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2945215

28 May 2018

Microscopic modes and free energies of 3-phosphoinositide-dependent kinase-1 (PDK1) binding with celecoxib and other inhibitors.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2945215

28 May 2018

Extra precision glide: docking and scoring incorporating a model of hydrophobic enclosure for protein-ligand complexes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2945215

28 May 2018

Molecular dynamics simulation of cocaine binding with human butyrylcholinesterase and its mutants

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2945215

28 May 2018

The SWISS-MODEL workspace: a web-based environment for protein structure homology modelling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2945215

28 May 2018

Immunoproteasomes: regulating the regulator

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2945215

28 May 2018

Glide: a new approach for rapid, accurate docking and scoring. 1. Method and assessment of docking accuracy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2945215

28 May 2018

Molecular mechanisms of novel therapeutic approaches for multiple myeloma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2945215

28 May 2018

The structure of the mammalian 20S proteasome at 2.75 A resolution

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2945215

28 May 2018

Novel therapies targeting the myeloma cell and its bone marrow microenvironment

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2945215

28 May 2018

The ubiquitin-proteasome pathway and proteasome inhibitors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2945215

28 May 2018

Antigen processing by the proteasome

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2945215

28 May 2018

Calculating structures and free energies of complex molecules: combining molecular mechanics and continuum models

1 reference

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28 May 2018

The catalytic sites of 20S proteasomes and their role in subunit maturation: a mutational and crystallographic study

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2945215

28 May 2018

The ubiquitin system

1 reference

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28 May 2018

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1 reference

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Structure of 20S proteasome from yeast at 2.4 A resolution

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Reduced surface: an efficient way to compute molecular surfaces

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A selective inhibitor of the immunoproteasome subunit LMP7 blocks cytokine production and attenuates progression of experimental arthritis.

1 reference

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Immunoproteasome and LMP2 polymorphism in aged and Alzheimer's disease brains

1 reference

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Neuronal induction of the immunoproteasome in Huntington's disease.

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Structure-based design of derivatives of tyropeptin A as the potent and selective inhibitors of mammalian 20S proteasome

1 reference

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based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1021/JP1058098

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Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20812720%20AND%20SRC:MED&resulttype=core&format=json

13 February 2020

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20812720%20AND%20SRC:MED&resulttype=core&format=json

13 February 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20812720%20AND%20SRC:MED&resulttype=core&format=json

13 February 2020

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