(Q42430715)

31 October 2017

Synthesis, SAR, and Pharmacological Characterization of Brain Penetrant P2X7 Receptor Antagonists (English)

1 reference

31 October 2017

Brad M Savall

1

1 reference

31 October 2017

Duncan Wu

2

1 reference

31 October 2017

Meri De Angelis

3

1 reference

31 October 2017

Nicholas I Carruthers

4

1 reference

31 October 2017

Hong Ao

5

1 reference

31 October 2017

Qi Wang

6

1 reference

31 October 2017

Brian Lord

7

1 reference

31 October 2017

Anindya Bhattacharya

8

1 reference

31 October 2017

Michael A Letavic

9

1 reference

31 October 2017

24 April 2015

1 reference

ACS Medicinal Chemistry Letters

31 October 2017

1 reference

31 October 2017

6

1 reference

31 October 2017

6

1 reference

31 October 2017

671-676

1 reference

Synthesis and Pharmacological Characterization of Two Novel, Brain Penetrating P2X7 Antagonists

31 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4468405

P2X7 antagonists as potential therapeutic agents for the treatment of CNS disorders

28 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4468405

Pharmacological characterization of a novel centrally permeable P2X7 receptor antagonist: JNJ-47965567.

28 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4468405

Efficacy and safety of CE-224,535, an antagonist of P2X7 receptor, in treatment of patients with rheumatoid arthritis inadequately controlled by methotrexate

28 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4468405

Optimization of the physicochemical and pharmacokinetic attributes in a 6-azauracil series of P2X7 receptor antagonists leading to the discovery of the clinical candidate CE-224,535.

28 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4468405

A meta-analysis of cytokines in major depression

28 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4468405

Antagonists of the P2X(7) receptor. From lead identification to drug development.

28 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4468405

IL-1beta is an essential mediator of the antineurogenic and anhedonic effects of stress

28 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4468405

Cytokines sing the blues: inflammation and the pathogenesis of depression

28 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4468405

Enantioselective organocatalytic hydride reduction

28 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4468405

Altered cytokine production in mice lacking P2X(7) receptors

28 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4468405

Identification of 2-oxo-N-(phenylmethyl)-4-imidazolidinecarboxamide antagonists of the P2X7 receptor

28 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4468405

Discovery and structure-activity relationships of a series of pyroglutamic acid amide antagonists of the P2X7 receptor

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4468405

Synthesis and biological activity of a series of tetrasubstituted-imidazoles as P2X(7) antagonists

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4468405

Structure-activity relationships and in vivo activity of (1H-pyrazol-4-yl)acetamide antagonists of the P2X(7) receptor

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4468405

Discovery of potent and selective adamantane-based small-molecule P2X(7) receptor antagonists/interleukin-1beta inhibitors

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4468405

Hit-to-Lead studies: The discovery of potent adamantane amide P2X7 receptor antagonists

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4468405

Imidazopiperidine amides as dipeptidyl peptidase IV inhibitors for the treatment of diabetes

16 August 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/26101572

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Copper-catalyzed N-arylation of imidazoles and benzimidazoles

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/26101572

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Copper-diamine-catalyzed N-arylation of pyrroles, pyrazoles, indazoles, imidazoles, and triazoles

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/26101572

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1021/ACSMEDCHEMLETT.5B00089

1 reference

31 October 2017

1 reference

31 October 2017

PubMed publication ID

26101572

1 reference