(Q42430729)

31 October 2017

Discovery and Optimization of Selective Nav1.8 Modulator Series That Demonstrate Efficacy in Preclinical Models of Pain (English)

1 reference

31 October 2017

Sharan K Bagal

1

1 reference

31 October 2017

Peter J Bungay

2

1 reference

31 October 2017

Stephen M Denton

3

1 reference

31 October 2017

Karl R Gibson

4

1 reference

31 October 2017

Melanie S Glossop

5

1 reference

31 October 2017

Tanya L Hay

6

1 reference

31 October 2017

Mark I Kemp

7

1 reference

31 October 2017

Charlotte A L Lane

8

1 reference

31 October 2017

Mark L Lewis

9

1 reference

31 October 2017

Graham N Maw

10

1 reference

31 October 2017

William A Million

11

1 reference

31 October 2017

C Elizabeth Payne

12

1 reference

31 October 2017

Cedric Poinsard

13

1 reference

31 October 2017

David J Rawson

14

1 reference

31 October 2017

Blanda L Stammen

15

1 reference

31 October 2017

Edward B Stevens

16

1 reference

31 October 2017

Lisa R Thompson

17

1 reference

31 October 2017

language of work or name

1 reference

29 April 2015

1 reference

ACS Medicinal Chemistry Letters

31 October 2017

1 reference

31 October 2017

6

1 reference

31 October 2017

6

1 reference

31 October 2017

650-654

1 reference

A novel selective and orally bioavailable Nav 1.8 channel blocker, PF-01247324, attenuates nociception and sensory neuron excitability

31 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4468395

Altered sodium channel gating as molecular basis for pain: contribution of activation, inactivation, and resurgent currents.

28 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4468395

Pain without nociceptors? Nav1.7-independent pain mechanisms.

28 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4468395

Ion channels as therapeutic targets: a drug discovery perspective

28 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4468395

Gain-of-function Nav1.8 mutations in painful neuropathy.

28 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4468395

Sodium channels in normal and pathological pain

28 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4468395

A-803467, a potent and selective Nav1.8 sodium channel blocker, attenuates neuropathic and inflammatory pain in the rat.

28 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4468395

Neuropathic pain develops normally in mice lacking both Na(v)1.7 and Na(v)1.8.

28 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4468395

Allometric scaling of pharmacokinetic parameters in drug discovery: can human CL, Vss and t1/2 be predicted from in-vivo rat data?

28 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4468395

Diversity of expression of the sensory neuron-specific TTX-resistant voltage-gated sodium ion channels SNS and SNS2.

28 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4468395

The tetrodotoxin-resistant sodium channel SNS has a specialized function in pain pathways

28 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4468395

PGE2 modulates the tetrodotoxin-resistant sodium current in neonatal rat dorsal root ganglion neurones via the cyclic AMP-protein kinase A cascade.

28 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4468395

Lipophilic efficiency: the most important efficiency metric in medicinal chemistry

28 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4468395

Prediction of aqueous solubility of organic compounds by the general solubility equation (GSE).

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4468395

A role for the TTX-resistant sodium channel Nav 1.8 in NGF-induced hyperalgesia, but not neuropathic pain

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4468395

Plasticity of sodium channel expression in DRG neurons in the chronic constriction injury model of neuropathic pain.

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4468395

MMP-Cliffs: systematic identification of activity cliffs on the basis of matched molecular pairs

16 August 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/26101568

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Nav1.8 expression is not restricted to nociceptors in mouse peripheral nervous system

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/26101568

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1021/ACSMEDCHEMLETT.5B00059

1 reference

31 October 2017

1 reference

31 October 2017

PubMed publication ID

26101568

1 reference