Wikidata

(Q424394)

English

TNF superfamily member 10

mammalian protein found in Homo sapiens

  • Apo-2 ligand
  • tumor necrosis factor ligand superfamily member 10
  • TNF-related apoptosis inducing ligand TRAIL
  • tumor necrosis factor (ligand) superfamily, member 10
  • Apo-2L
  • TNFSF10
  • TNF-related apoptosis-inducing ligand
  • tumor necrosis factor superfamily member 10
  • chemokine tumor necrosis factor ligand superfamily member 10
  • tumor necrosis factor apoptosis-inducing ligand splice variant delta
  • tumor necrosis factor ligand 6A
  • Protein TRAIL
  • tumor necrosis factor (ligand) family, member 10
  • TRAIL
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No label defined

No description defined

Statements

molecular function
protein binding
determination method or standard
IPI
9 references
retrieved
9 May 2019
stated in
Cullin3-based polyubiquitination and p62-dependent aggregation of caspase-8 mediate extrinsic apoptosis signaling
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50591
determination method or standard
IPI
retrieved
9 May 2019
stated in
Inhibition of vacuolar ATPase attenuates the TRAIL-induced activation of caspase-8 and modulates the trafficking of TRAIL receptosomes
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50591
determination method or standard
IPI
retrieved
9 May 2019
stated in
Identification of a novel proapoptotic function of resveratrol in fat cells: SIRT1-independent sensitization to TRAIL-induced apoptosis
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50591
determination method or standard
IPI
retrieved
9 May 2019
stated in
Identification of a novel pro-apoptotic role of NF-κB in the regulation of TRAIL- and CD95-mediated apoptosis of glioblastoma cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50591
determination method or standard
IPI
retrieved
9 May 2019
stated in
Bortezomib primes neuroblastoma cells for TRAIL-induced apoptosis by linking the death receptor to the mitochondrial pathway
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50591
determination method or standard
IPI
retrieved
9 May 2019
stated in
Triggering cell death: the crystal structure of Apo2L/TRAIL in a complex with death receptor 5
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50591
determination method or standard
IPI
retrieved
9 May 2019
stated in
Bortezomib primes glioblastoma, including glioblastoma stem cells, for TRAIL by increasing tBid stability and mitochondrial apoptosis
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50591
determination method or standard
IPI
retrieved
9 May 2019
stated in
Histone deacetylase inhibitors sensitize glioblastoma cells to TRAIL-induced apoptosis by c-myc-mediated downregulation of cFLIP
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50591
determination method or standard
IPI
retrieved
9 May 2019
stated in
Multivalent DR5 peptides activate the TRAIL death pathway and exert tumoricidal activity
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50591
determination method or standard
IPI
cell component
biological process
positive regulation of extrinsic apoptotic signaling pathway
determination method or standard
IBA
IDA
IEA
5 references
retrieved
9 May 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50591
determination method or standard
IEA
retrieved
9 May 2019
stated in
Identification of a novel proapoptotic function of resveratrol in fat cells: SIRT1-independent sensitization to TRAIL-induced apoptosis
GOA
curator
UniProt
UniProt protein ID
P50591
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50591
determination method or standard
IDA
retrieved
9 May 2019
stated in
Bortezomib primes glioblastoma, including glioblastoma stem cells, for TRAIL by increasing tBid stability and mitochondrial apoptosis
GOA
curator
UniProt
UniProt protein ID
P50591
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50591
determination method or standard
IDA
retrieved
9 May 2019
stated in
Histone deacetylase inhibitors sensitize glioblastoma cells to TRAIL-induced apoptosis by c-myc-mediated downregulation of cFLIP
GOA
curator
UniProt
UniProt protein ID
P50591
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50591
determination method or standard
IDA
retrieved
9 May 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50591
determination method or standard
IBA
Gene Atlas image
PBB GE TNFSF10 202688 at fs.png
732 × 530; 10 KB
0 references
Commons category
Apoptosis-2 ligand, apo2l or TRAIL
0 references

Identifiers

MeSH descriptor ID
D053221
subject named as
TNF-Related Apoptosis-Inducing Ligand
0 references
 
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