(Q42452257)

31 October 2017

Overexpression of ATP-activated P2X7 receptors in the intestinal mucosa is implicated in the pathogenesis of Crohn's disease (English)

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31 October 2017

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31 October 2017

Robson Coutinho-Silva

object named as

Robson Coutinho-Silva

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author name string

Adriane R Neves

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31 October 2017

Morgana T L Castelo-Branco

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31 October 2017

Vanessa R Figliuolo

3

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31 October 2017

Claudio Bernardazzi

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31 October 2017

Fernanda Buongusto

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31 October 2017

Agnes Yoshimoto

6

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31 October 2017

Hayandra F Nanini

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31 October 2017

Claudia M L M Coutinho

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31 October 2017

Antonio José V Carneiro

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31 October 2017

language of work or name

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1 March 2014

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Inflammatory Bowel Diseases

31 October 2017

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31 October 2017

20

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31 October 2017

3

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31 October 2017

444-457

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Inflammatory Bowel Disease

31 October 2017

1 reference

https://api.crossref.org/works/10.1097%2F01.MIB.0000441201.10454.06

Inflammatory bowel disease: cause and immunobiology

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2F01.MIB.0000441201.10454.06

Unravelling the pathogenesis of inflammatory bowel disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2F01.MIB.0000441201.10454.06

The genetics and immunopathogenesis of inflammatory bowel disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2F01.MIB.0000441201.10454.06

Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2F01.MIB.0000441201.10454.06

Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2F01.MIB.0000441201.10454.06

Hints of hidden heritability in GWAS.

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2F01.MIB.0000441201.10454.06

Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2F01.MIB.0000441201.10454.06

A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2F01.MIB.0000441201.10454.06

A genome-wide association study identifies IL23R as an inflammatory bowel disease gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2F01.MIB.0000441201.10454.06

A genome-wide association scan of nonsynonymous SNPs identifies a susceptibility variant for Crohn disease in ATG16L1

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2F01.MIB.0000441201.10454.06

The transcription factor T-bet regulates mucosal T cell activation in experimental colitis and Crohn's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2F01.MIB.0000441201.10454.06

The immunological and genetic basis of inflammatory bowel disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2F01.MIB.0000441201.10454.06

Expression of interleukin 1 beta and interleukin 1 beta converting enzyme by intestinal macrophages in health and inflammatory bowel disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2F01.MIB.0000441201.10454.06

Nod2 mutation in Crohn's disease potentiates NF-kappaB activity and IL-1beta processing

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2F01.MIB.0000441201.10454.06

Interleukin 18 is a primary mediator of the inflammation associated with dextran sulphate sodium induced colitis: blocking interleukin 18 attenuates intestinal damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2F01.MIB.0000441201.10454.06

Macrophage-derived IL-18-mediated intestinal inflammation in the murine model of Crohn's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2F01.MIB.0000441201.10454.06

New bioinformatics approach to analyze gene expressions and signaling pathways reveals unique purine gene dysregulation profiles that distinguish between CD and UC.

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2F01.MIB.0000441201.10454.06

ADOA3R as a therapeutic target in experimental colitis: proof by validated high-density oligonucleotide microarray analysis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2F01.MIB.0000441201.10454.06

ATP drives lamina propria T(H)17 cell differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2F01.MIB.0000441201.10454.06

Novel data point to a broader mechanism of action of oxidized ATP: the P2X7 receptor is not the only target

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2F01.MIB.0000441201.10454.06

Two pathways for ATP release from host cells in enteropathogenic Escherichia coli infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2F01.MIB.0000441201.10454.06

The role of P2 receptors in controlling infections by intracellular pathogens

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2F01.MIB.0000441201.10454.06

The P2X7 receptor: a key player in IL-1 processing and release

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2F01.MIB.0000441201.10454.06

Characterizing the presence and sensitivity of the P2X7 receptor in different compartments of the gut.

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2F01.MIB.0000441201.10454.06

Extracellular ATP induces cell death in human intestinal epithelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2F01.MIB.0000441201.10454.06

Inhibition of chlamydial infectious activity due to P2X7R-dependent phospholipase D activation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2F01.MIB.0000441201.10454.06

ATP-mediated killing of intracellular mycobacteria by macrophages is a P2X(7)-dependent process inducing bacterial death by phagosome-lysosome fusion

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2F01.MIB.0000441201.10454.06

Glu496 to Ala polymorphism in the P2X7 receptor impairs ATP-induced IL-1 beta release from human monocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2F01.MIB.0000441201.10454.06

P2X7 receptor polymorphism impairs extracellular adenosine 5'-triphosphate-induced interleukin-18 release from human monocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2F01.MIB.0000441201.10454.06

Cryopyrin activates the inflammasome in response to toxins and ATP

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2F01.MIB.0000441201.10454.06

Pannexin-1 mediates large pore formation and interleukin-1beta release by the ATP-gated P2X7 receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2F01.MIB.0000441201.10454.06

Common variants in the NLRP3 region contribute to Crohn's disease susceptibility

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2F01.MIB.0000441201.10454.06

Combined polymorphisms in genes encoding the inflammasome components NALP3 and CARD8 confer susceptibility to Crohn's disease in Swedish men.

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2F01.MIB.0000441201.10454.06

Expression of purinergic receptors and modulation of P2X7 function by the inflammatory cytokine IFNgamma in human epithelial cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2F01.MIB.0000441201.10454.06

A simple index of Crohn's-disease activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2F01.MIB.0000441201.10454.06

A simple clinical colitis activity index

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2F01.MIB.0000441201.10454.06

Histopathological evaluation of colonic mucosal biopsy specimens in chronic inflammatory bowel disease: diagnostic implications

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2F01.MIB.0000441201.10454.06

Biopsy studies in ulcerative colitis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2F01.MIB.0000441201.10454.06

Unfractionated heparin and new heparin analogues from ascidians (chordate-tunicate) ameliorate colitis in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2F01.MIB.0000441201.10454.06

Loss of transforming growth factor beta signalling in the intestine contributes to tissue injury in inflammatory bowel disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2F01.MIB.0000441201.10454.06

The immunology of mucosal models of inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2F01.MIB.0000441201.10454.06

Changes in colonic mucosal permeability in mouse colitis induced with dextran sulfate sodium.

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2F01.MIB.0000441201.10454.06

Purinergic control of T cell activation by ATP released through pannexin-1 hemichannels.

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2F01.MIB.0000441201.10454.06

Extracellular ATP mediates mast cell-dependent intestinal inflammation through P2X7 purinoceptors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2F01.MIB.0000441201.10454.06

Amplification loop of the inflammatory process is induced by P2X7R activation in intestinal epithelial cells in response to neutrophil transepithelial migration

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2F01.MIB.0000441201.10454.06

Signaling through purinergic receptors for ATP induces human cutaneous innate and adaptive Th17 responses: implications in the pathogenesis of psoriasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2F01.MIB.0000441201.10454.06

Absence of the P2X7 receptor alters leukocyte function and attenuates an inflammatory response

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2F01.MIB.0000441201.10454.06

High sensitivity of CD4+CD25+ regulatory T cells to extracellular metabolites nicotinamide adenine dinucleotide and ATP: a role for P2X7 receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2F01.MIB.0000441201.10454.06

High sensitivity of intestinal CD8+ T cells to nucleotides indicates P2X7 as a regulator for intestinal T cell responses

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2F01.MIB.0000441201.10454.06

ATP inhibits the generation and function of regulatory T cells through the activation of purinergic P2X receptors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2F01.MIB.0000441201.10454.06

Autocrine regulation of T-cell activation by ATP release and P2X7 receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2F01.MIB.0000441201.10454.06

Adenosine 5'-triphosphate and adenosine as endogenous signaling molecules in immunity and inflammation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2F01.MIB.0000441201.10454.06

Epithelial barrier defects in ulcerative colitis: characterization and quantification by electrophysiological imaging.

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2F01.MIB.0000441201.10454.06

Changes in expression and distribution of claudin 2, 5 and 8 lead to discontinuous tight junctions and barrier dysfunction in active Crohn's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2F01.MIB.0000441201.10454.06

Downregulation of epithelial apoptosis and barrier repair in active Crohn's disease by tumour necrosis factor alpha antibody treatment

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2F01.MIB.0000441201.10454.06

Homeostatic control of lymphocyte survival: potential origins and implications

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2F01.MIB.0000441201.10454.06

Human macrophage activation programs induced by bacterial pathogens

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2F01.MIB.0000441201.10454.06

Liaisons dangereuses: P2X(7) and the inflammasome.

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2F01.MIB.0000441201.10454.06

Bacterial RNA and small antiviral compounds activate caspase-1 through cryopyrin/Nalp3

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2F01.MIB.0000441201.10454.06

Pannexin1 is part of the pore forming unit of the P2X(7) receptor death complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2F01.MIB.0000441201.10454.06

ATP is released by monocytes stimulated with pathogen-sensing receptor ligands and induces IL-1beta and IL-18 secretion in an autocrine way

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2F01.MIB.0000441201.10454.06

Signaling at purinergic P2X receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2F01.MIB.0000441201.10454.06

10.1097/01.MIB.0000441201.10454.06

21 January 2018

Identifiers

DOI

1 reference

31 October 2017

1 reference