(Q42462866)

English

Peroxisome proliferator-activated receptor alpha (PPARalpha) protects against oleate-induced INS-1E beta cell dysfunction by preserving carbohydrate metabolism

scientific article published on 12 November 2009

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scholarly article

1 reference

Europe PubMed Central

1 November 2017

Peroxisome proliferator-activated receptor alpha (PPARalpha) protects against oleate-induced INS-1E beta cell dysfunction by preserving carbohydrate metabolism (English)

1 reference

Europe PubMed Central

1 November 2017

Susanne Mandrup

7

1 reference

Europe PubMed Central

1 November 2017

Pierre Maechler

object named as

P Maechler

8

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author name string

F Frigerio

1

1 reference

Europe PubMed Central

1 November 2017

T Brun

2

1 reference

Europe PubMed Central

1 November 2017

C Bartley

3

1 reference

Europe PubMed Central

1 November 2017

A Usardi

4

1 reference

Europe PubMed Central

1 November 2017

D Bosco

5

1 reference

Europe PubMed Central

1 November 2017

K Ravnskjaer

6

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Europe PubMed Central

1 November 2017

publication date

12 November 2009

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Europe PubMed Central

1 November 2017

1 reference

Europe PubMed Central

1 November 2017

53

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Europe PubMed Central

1 November 2017

2

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Europe PubMed Central

1 November 2017

331-340

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Europe PubMed Central

1 November 2017

https://scigraph.springernature.com/pub.10.1007/s00125-009-1590-6

0 references

Triglyceride accumulation protects against fatty acid-induced lipotoxicity

1 reference

https://pubmed.ncbi.nlm.nih.gov/19908022

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glucose Sensitivity and Metabolism-Secretion Coupling Studied during Two-Year Continuous Culture in INS-1E Insulinoma Cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/19908022

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Peroxisome proliferator-activated receptors and insulin secretion

1 reference

https://pubmed.ncbi.nlm.nih.gov/19908022

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of bezafibrate on beta-cell function of rat pancreatic islets

1 reference

https://pubmed.ncbi.nlm.nih.gov/19908022

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Peroxisome proliferator-activated receptor alpha mediates the effects of high-fat diet on hepatic gene expression

1 reference

https://pubmed.ncbi.nlm.nih.gov/19908022

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pancreatic islet adaptation to fasting is dependent on peroxisome proliferator-activated receptor alpha transcriptional up-regulation of fatty acid oxidation

1 reference

https://pubmed.ncbi.nlm.nih.gov/19908022

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Detection of endogenous biotin-containing proteins in bone and cartilage cells with streptavidin systems

1 reference

https://pubmed.ncbi.nlm.nih.gov/19908022

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Long-term exposure of rat pancreatic islets to fatty acids inhibits glucose-induced insulin secretion and biosynthesis through a glucose fatty acid cycle

1 reference

https://pubmed.ncbi.nlm.nih.gov/19908022

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The antiepileptic drug topiramate preserves metabolism-secretion coupling in insulin secreting cells chronically exposed to the fatty acid oleate.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19908022

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Peroxisome proliferator-activated receptor (PPAR)-alpha agonism prevents the onset of type 2 diabetes in Zucker diabetic fatty rats: A comparison with PPAR gamma agonism.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19908022

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

PPARalpha suppresses insulin secretion and induces UCP2 in insulinoma cells.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19908022

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Peroxisome proliferator-activated receptor alpha (PPARalpha) potentiates, whereas PPARgamma attenuates, glucose-stimulated insulin secretion in pancreatic beta-cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/19908022

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Characterization and Regulation of Pyruvate Carboxylase of Bacillus licheniformis

1 reference

https://pubmed.ncbi.nlm.nih.gov/19908022

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mitochondrial diabetes and its lessons for common Type 2 diabetes.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19908022

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of peroxisome proliferator-activated receptor alpha in disease of pancreatic beta cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/19908022

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Peroxisome proliferator-activated receptor alpha improves pancreatic adaptation to insulin resistance in obese mice and reduces lipotoxicity in human islets.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19908022

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inverse relationship between cytotoxicity of free fatty acids in pancreatic islet cells and cellular triglyceride accumulation.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19908022

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A critical role for the peroxisome proliferator-activated receptor alpha (PPARalpha) in the cellular fasting response: the PPARalpha-null mouse as a model of fatty acid oxidation disorders

1 reference

https://pubmed.ncbi.nlm.nih.gov/19908022

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Unbound free fatty acid levels in human serum.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19908022

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Acute (24 h) activation of peroxisome proliferator-activated receptor-alpha (PPARalpha) reverses high-fat feeding-induced insulin hypersecretion in vivo and in perifused pancreatic islets

1 reference

https://pubmed.ncbi.nlm.nih.gov/19908022

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

"New" hepatic fat activates PPARalpha to maintain glucose, lipid, and cholesterol homeostasis

1 reference

https://pubmed.ncbi.nlm.nih.gov/19908022

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Lipotoxicity of beta-cells in obesity and in other causes of fatty acid spillover

1 reference

https://pubmed.ncbi.nlm.nih.gov/19908022

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Palmitate and oleate induce the immediate-early response genes c-fos and nur-77 in the pancreatic beta-cell line INS-1.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19908022

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Partial resistance to peroxisome proliferator-activated receptor-alpha agonists in ZDF rats is associated with defective hepatic mitochondrial metabolism.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19908022

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molecular Mechanism of Insulin Resistance and Obesity

1 reference

https://pubmed.ncbi.nlm.nih.gov/19908022

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Long-chain fatty acids inhibit acetyl-CoA carboxylase gene expression in the pancreatic beta-cell line INS-1.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19908022

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dehydroepiandrosterone sulfate and beta-cell function: enhanced glucose-induced insulin secretion and altered gene expression in rodent pancreatic beta-cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/19908022

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Peroxisome proliferator-activated receptor alpha mediates the adaptive response to fasting

1 reference

https://pubmed.ncbi.nlm.nih.gov/19908022

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The regulation of acetyl-CoA carboxylase--a potential target for the action of hypolipidemic agents

1 reference

https://pubmed.ncbi.nlm.nih.gov/19908022

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Analysis of long-chain free fatty acid binding to bovine serum albumin by determination of stepwise equilibrium constants

1 reference

https://pubmed.ncbi.nlm.nih.gov/19908022

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Oleate reverses palmitate-induced insulin resistance and inflammation in skeletal muscle cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/19908022

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Diabetes-associated mitochondrial DNA mutation A3243G impairs cellular metabolic pathways necessary for beta cell function.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19908022

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

PPARs and the complex journey to obesity

1 reference

https://pubmed.ncbi.nlm.nih.gov/19908022

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of nuclear receptors in the modulation of insulin secretion in lipid-induced insulin resistance

1 reference

https://pubmed.ncbi.nlm.nih.gov/19908022

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Chronic palmitate exposure inhibits AMPKalpha and decreases glucose-stimulated insulin secretion from beta-cells: modulation by fenofibrate.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19908022

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Saturated fatty acids synergize with elevated glucose to cause pancreatic beta-cell death

1 reference

https://pubmed.ncbi.nlm.nih.gov/19908022

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Monounsaturated fatty acids prevent the deleterious effects of palmitate and high glucose on human pancreatic beta-cell turnover and function

1 reference

https://pubmed.ncbi.nlm.nih.gov/19908022

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Metabolic fate of glucose in purified islet cells. Glucose-regulated anaplerosis in beta cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/19908022

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A simple method for the isolation and purification of total lipides from animal tissues

1 reference

https://pubmed.ncbi.nlm.nih.gov/19908022

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Distinct effects of saturated and monounsaturated fatty acids on beta-cell turnover and function

1 reference

https://pubmed.ncbi.nlm.nih.gov/19908022

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Islet beta cell failure in type 2 diabetes

1 reference

https://pubmed.ncbi.nlm.nih.gov/19908022

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

PPARalpha activation reverses adverse effects induced by high-saturated-fat feeding on pancreatic beta-cell function in late pregnancy

1 reference

https://pubmed.ncbi.nlm.nih.gov/19908022

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Insulin resistance and pancreatic beta cell failure

1 reference

https://pubmed.ncbi.nlm.nih.gov/19908022

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Genetic regulation of metabolic pathways in beta-cells disrupted by hyperglycemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/19908022

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1007/S00125-009-1590-6

1 reference

Europe PubMed Central

1 November 2017

1 reference

Europe PubMed Central

1 November 2017

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