(Q42478456)

1 November 2017

title

Characterisation of (R/S)-propafenone and its metabolites as substrates and inhibitors of P-glycoprotein (English)

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1 November 2017

Ute Hofmann

3

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author name string

Iouri Bachmakov

1

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1 November 2017

Sabine Rekersbrink

2

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1 November 2017

Michel Eichelbaum

4

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1 November 2017

Martin F Fromm

5

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1 November 2017

publication date

1 March 2005

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Naunyn-Schmiedeberg's Archives of Pharmacology

1 November 2017

published in

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1 November 2017

volume

371

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1 November 2017

issue

3

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1 November 2017

page(s)

195-201

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https://scigraph.springernature.com/pub.10.1007/s00210-005-1025-y

1 November 2017

exact match

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cites work

Inhibition of P-glycoprotein-mediated drug transport: A unifying mechanism to explain the interaction between digoxin and quinidine [seecomments]

1 reference

https://api.crossref.org/works/10.1007%2FS00210-005-1025-Y

Genetically-determined interaction between propafenone and low dose quinidine: role of active metabolites in modulating net drug effect

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00210-005-1025-Y

Characterisation of cerivastatin as a P-glycoprotein substrate: studies in P-glycoprotein-expressing cell monolayers and mdr1a/b knock-out mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-005-1025-Y

Stereoselective disposition and pharmacologic activity of propafenone enantiomers

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-005-1025-Y

A randomized, placebo-controlled trial of propafenone in the prophylaxis of paroxysmal supraventricular tachycardia and paroxysmal atrial fibrillation. UK Propafenone PSVT Study Group

21 January 2018

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12 December 2020

P-glycoprotein-mediated transport of digitoxin, alpha-methyldigoxin and beta-acetyldigoxin

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12 December 2020

Multidrug resistance-reversing agents increase vinblastine distribution in normal tissues expressing the P-glycoprotein but do not enhance drug penetration in brain and testis.

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12 December 2020

Polymorphism of propafenone metabolism and disposition in man: clinical and pharmacokinetic consequences

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12 December 2020

An enantiomer-enantiomer interaction of (S)- and (R)-propafenone modifies the effect of racemic drug therapy

1 reference

12 December 2020

Outpatient treatment of recent-onset atrial fibrillation with the "pill-in-the-pocket" approach

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12 December 2020

Determination of propafenone and its phase I and phase II metabolites in plasma and urine by high-performance liquid chromatography-electrospray ionization mass spectrometry

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12 December 2020

A subset of highly effective propafenone-type multidrug resistance modulators lacks effects on cardiac action potential and mechanical twitch parameters of rat papillary muscles

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12 December 2020

Effects of coadministration of propafenone on the pharmacokinetics of digoxin in healthy volunteer subjects

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12 December 2020

Biological, pharmaceutical, and analytical considerations with respect to the transport media used in the absorption screening system, Caco-2.

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12 December 2020

Characterization of the common genetic defect in humans deficient in debrisoquine metabolism

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12 December 2020

Identification and characterization of the cytochrome P450 enzymes involved in N-dealkylation of propafenone: molecular base for interaction potential and variable disposition of active metabolites

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12 December 2020

The digoxin-propafenone interaction: characterization of a mechanism using renal tubular cell monolayers

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12 December 2020

Ciclosporin-propafenone interaction

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12 December 2020

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12 December 2020

The role of intestinal P-glycoprotein in the interaction of digoxin and rifampin

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12 December 2020

Are there stereoselective electrophysiologic effects of intravenously administered (S)- or (R)-propafenone hydrochloride in patients with supraventricular tachycardia?

1 reference

12 December 2020

Influence of renal function on the steady-state pharmacokinetics of the antiarrhythmic propafenone and its Phase I and Phase II metabolites

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12 December 2020

Interaction between digoxin and propafenone

1 reference

12 December 2020

A family and population study of the genetic polymorphism of debrisoquine oxidation in a white British population.

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12 December 2020

Interaction between digoxin and propafenone in children

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12 December 2020

Serum digoxin levels related to plasma propafenone levels during concomitant treatment

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12 December 2020

Quinidine-digoxin interaction: Pharmacokinetics, underlying mechanism and clinical implications

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12 December 2020

Intramolecular distribution of hydrophobicity influences pharmacological activity of propafenone-type MDR modulators

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12 December 2020

A controlled trial of propafenone for treatment of frequent and repetitive ventricular premature complexes

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12 December 2020

Interaction between digoxin and calcium antagonists and antiarrhythmic drugs

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12 December 2020

Absence of the mdr1a P-Glycoprotein in mice affects tissue distribution and pharmacokinetics of dexamethasone, digoxin, and cyclosporin A.

1 reference

12 December 2020

Enantiomer/enantiomer interaction of (S)- and (R)-propafenone for cytochrome P450IID6-catalyzed 5-hydroxylation: in vitro evaluation of the mechanism

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12 December 2020

The drug transporter P-glycoprotein limits oral absorption and brain entry of HIV-1 protease inhibitors

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12 December 2020

P-glycoprotein: a defense mechanism limiting oral bioavailability and CNS accumulation of drugs

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12 December 2020

Clinical practice. Newly diagnosed atrial fibrillation

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12 December 2020

Caco-2 monolayers in experimental and theoretical predictions of drug transport

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12 December 2020

Structure-activity relationship studies of propafenone analogs based on P-glycoprotein ATPase activity measurements.

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12 December 2020

Propafenone. A reappraisal of its pharmacology, pharmacokinetics and therapeutic use in cardiac arrhythmias

1 reference

12 December 2020

Structural requirements for activity of propafenone-type modulators in P-glycoprotein-mediated multidrug resistance

1 reference

12 December 2020

10.1007/S00210-005-1025-Y

Identifiers

DOI

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1 November 2017

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