(Q42485937)

English

Inhibition of triclabendazole metabolism in vitro by ketoconazole increases disruption to the tegument of a triclabendazole-resistant isolate of Fasciola hepatica

scientific article published on 26 March 2011

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

1 November 2017

Inhibition of triclabendazole metabolism in vitro by ketoconazole increases disruption to the tegument of a triclabendazole-resistant isolate of Fasciola hepatica (English)

1 reference

Europe PubMed Central

PubMed publication ID

1 November 2017

triclabendazole

1 reference

based on heuristic

inferred from title

Fasciola hepatica

object named as

Fasciola hepatica

1 reference

based on heuristic

inferred from title

author name string

C Devine

1

1 reference

Europe PubMed Central

PubMed publication ID

1 November 2017

G P Brennan

2

1 reference

Europe PubMed Central

PubMed publication ID

1 November 2017

C E Lanusse

3

1 reference

Europe PubMed Central

PubMed publication ID

1 November 2017

L I Alvarez

4

1 reference

Europe PubMed Central

PubMed publication ID

1 November 2017

A Trudgett

5

1 reference

Europe PubMed Central

PubMed publication ID

1 November 2017

E Hoey

6

1 reference

Europe PubMed Central

PubMed publication ID

1 November 2017

I Fairweather

7

1 reference

Europe PubMed Central

PubMed publication ID

1 November 2017

publication date

26 March 2011

1 reference

Europe PubMed Central

PubMed publication ID

1 November 2017

Parasitology Research

1 reference

Europe PubMed Central

PubMed publication ID

1 November 2017

109

1 reference

Europe PubMed Central

PubMed publication ID

1 November 2017

4

1 reference

Europe PubMed Central

PubMed publication ID

1 November 2017

981-995

1 reference

Europe PubMed Central

PubMed publication ID

1 November 2017

https://scigraph.springernature.com/pub.10.1007/s00436-011-2304-9

0 references

Altered drug influx/efflux and enhanced metabolic activity in triclabendazole-resistant liver flukes

1 reference

https://api.crossref.org/works/10.1007%2FS00436-011-2304-9

21 January 2018

Role of ABC transporters in veterinary drug research and parasite resistance.

1 reference

https://api.crossref.org/works/10.1007%2FS00436-011-2304-9

21 January 2018

Ketoconazole increases the plasma levels of ivermectin in sheep.

1 reference

https://api.crossref.org/works/10.1007%2FS00436-011-2304-9

21 January 2018

Fasciola hepatica: Ultrastructural changes to the tegument of juvenile flukes following incubation in vitro with the deacetylated (amine) metabolite of diamphencthide

1 reference

https://api.crossref.org/works/10.1007%2FS00436-011-2304-9

21 January 2018

P-glycoprotein interfering agents potentiate ivermectin susceptibility in ivermectin sensitive and resistant isolates of Teladorsagia circumcincta and Haemonchus contortus.

1 reference

https://api.crossref.org/works/10.1007%2FS00436-011-2304-9

21 January 2018

Fasciola hepatica: surface and internal tegumental changes induced by treatment in vitro with the sulphoxide metabolite of albendazole ('Valbazen').

1 reference

https://api.crossref.org/works/10.1007%2FS00436-011-2304-9

21 January 2018

Xenobiotic metabolizing enzymes and metabolism of anthelminthics in helminths.

1 reference

https://api.crossref.org/works/10.1007%2FS00436-011-2304-9

21 January 2018

Effect of the metabolic inhibitor, methimazole on the drug susceptibility of a triclabendazole-resistant isolate of Fasciola hepatica

1 reference

https://api.crossref.org/works/10.1007%2FS00436-011-2304-9

21 January 2018

Inhibition of cytochrome P450-mediated metabolism enhances ex vivo susceptibility of Fasciola hepatica to triclabendazole

1 reference

https://api.crossref.org/works/10.1007%2FS00436-011-2304-9

21 January 2018

Potentiation of triclabendazole sulphoxide-induced tegumental disruption by methimazole in a triclabendazole-resistant isolate of Fasciola hepatica

1 reference

https://api.crossref.org/works/10.1007%2FS00436-011-2304-9

21 January 2018

Enhancement of the drug susceptibility of a triclabendazole-resistant isolate of Fasciola hepatica using the metabolic inhibitor ketoconazole

1 reference

https://api.crossref.org/works/10.1007%2FS00436-011-2304-9

21 January 2018

Piperonyl butoxide enhances triclabendazole action against triclabendazole-resistant Fasciola hepatica

1 reference

https://api.crossref.org/works/10.1007%2FS00436-011-2304-9

21 January 2018

Enhancement of moxidectin bioavailability in lamb by a natural flavonoid: quercetin.

1 reference

https://api.crossref.org/works/10.1007%2FS00436-011-2304-9

21 January 2018

Fasciola hepatica: tegumental changes induced in vitro by the deacetylated (amine) metabolite of diamphenethide

1 reference

https://api.crossref.org/works/10.1007%2FS00436-011-2304-9

21 January 2018

Relative activity of triclabendazole metabolites against the liver fluke, Fasciola hepatica

1 reference

https://api.crossref.org/works/10.1007%2FS00436-011-2304-9

21 January 2018

Electron microscopical study to assess the in vitro effects of the synthetic trioxolane OZ78 against the liver fluke, Fasciola hepatica

1 reference

https://api.crossref.org/works/10.1007%2FS00436-011-2304-9

21 January 2018

Increased expression of ABC transport proteins is associated with ivermectin resistance in the model nematode Caenorhabditis elegans

1 reference

https://api.crossref.org/works/10.1007%2FS00436-011-2304-9

21 January 2018

An update on P-glycoprotein and drug resistance in Schistosoma mansoni

1 reference

https://api.crossref.org/works/10.1007%2FS00436-011-2304-9

21 January 2018

In vivo effects of cyclosporin A and ketoconazole on the pharmacokinetics of representative substrates for P-glycoprotein and cytochrome P450 (CYP) 3A in rats

1 reference

https://api.crossref.org/works/10.1007%2FS00436-011-2304-9

21 January 2018

P-glycoprotein in helminths: function and perspectives for anthelmintic treatment and reversal of resistance

1 reference

https://api.crossref.org/works/10.1007%2FS00436-011-2304-9

21 January 2018

Interrelationship between substrates and inhibitors of human CYP3A and P-glycoprotein.

1 reference

https://api.crossref.org/works/10.1007%2FS00436-011-2304-9

21 January 2018

Clinical pharmacokinetics and metabolism of benzimidazole anthelmintics in ruminants

1 reference

https://api.crossref.org/works/10.1007%2FS00436-011-2304-9

21 January 2018

ABC transporter modulation: a strategy to enhance the activity of macrocyclic lactone anthelmintics

1 reference

https://api.crossref.org/works/10.1007%2FS00436-011-2304-9

21 January 2018

Interaction of macrocyclic lactones with the multidrug transporters: the bases of the pharmacokinetics of lipid-like drugs.

1 reference

https://api.crossref.org/works/10.1007%2FS00436-011-2304-9

21 January 2018

Interference with P-glycoprotein improves ivermectin activity against adult resistant nematodes in sheep

1 reference

https://api.crossref.org/works/10.1007%2FS00436-011-2304-9

21 January 2018

Adult triclabendazole-resistant Fasciola hepatica: surface and subsurface tegumental responses to in vitro treatment with the sulphoxide metabolite of the experimental fasciolicide compound alpha

1 reference

https://api.crossref.org/works/10.1007%2FS00436-011-2304-9

21 January 2018

Immature triclabendazole-resistant Fasciola hepatica: tegumental responses to in vitro treatment with the sulphoxide metabolite of the experimental fasciolicide compound alpha

1 reference

https://api.crossref.org/works/10.1007%2FS00436-011-2304-9

21 January 2018

Surface and internal tegumental changes in juvenile Fasciola hepatica following treatment in vivo with the experimental fasciolicide, compound alpha

1 reference

https://api.crossref.org/works/10.1007%2FS00436-011-2304-9

21 January 2018

Ultrastructural changes to the tegumental system and the gastrodermal cells in adult Fasciola hepatica following in vivo treatment with the experimental fasciolicide, compound alpha

1 reference

https://api.crossref.org/works/10.1007%2FS00436-011-2304-9

21 January 2018

Ultrastructural changes induced in the tegument and gut of Fasciola hepatica following in vivo and in vitro drug treatment with nitroxynil (Trodax).

1 reference

https://api.crossref.org/works/10.1007%2FS00436-011-2304-9

21 January 2018

Morphological response of triclabendazole-susceptible and triclabendazole-resistant isolates of Fasciola hepatica to treatment in vitro with nitroxynil (Trodax).

1 reference

https://api.crossref.org/works/10.1007%2FS00436-011-2304-9

21 January 2018

Transmission electron microscope study of the ultrastructural changes induced in the tegument and gut of Fasciola hepatica following in vivo drug treatment with clorsulon.

1 reference

https://api.crossref.org/works/10.1007%2FS00436-011-2304-9

21 January 2018

Ultrastructural observations on oral ingestion and trans-tegumental uptake of clorsulon by the liver fluke, Fasciola hepatica

1 reference

https://api.crossref.org/works/10.1007%2FS00436-011-2304-9

21 January 2018

Fasciola hepatica: ultrastructural effects of a combination of triclabendazole and clorsulon against mature fluke.

1 reference

https://api.crossref.org/works/10.1007%2FS00436-011-2304-9

21 January 2018

Schistosoma mansoni P-glycoprotein levels increase in response to praziquantel exposure and correlate with reduced praziquantel susceptibility

1 reference

https://api.crossref.org/works/10.1007%2FS00436-011-2304-9

21 January 2018

Effects of the multidrug-resistance-reversing agents verapamil and CL 347,099 on the efficacy of ivermectin or moxidectin against unselected and drug-selected strains of Haemonchus contortus in jirds (Meriones unguiculatus).

1 reference

https://api.crossref.org/works/10.1007%2FS00436-011-2304-9

21 January 2018

Triclabendazole biotransformation and comparative diffusion of the parent drug and its oxidized metabolites into Fasciola hepatica

1 reference

https://api.crossref.org/works/10.1007%2FS00436-011-2304-9

21 January 2018

Drug transport mechanisms in helminth parasites: passive diffusion of benzimidazole anthelmintics

1 reference

https://api.crossref.org/works/10.1007%2FS00436-011-2304-9

21 January 2018

Adult triclabendazole-resistant Fasciola hepatica: morphological changes in the tegument and gut following in vivo treatment with artemether in the rat model

1 reference

https://api.crossref.org/works/10.1007%2FS00436-011-2304-9

21 January 2018

Inhibition and induction of human cytochrome P450 enzymes: current status

1 reference

https://api.crossref.org/works/10.1007%2FS00436-011-2304-9

21 January 2018

The comparative metabolism of triclabendazole sulphoxide by triclabendazole-susceptible and triclabendazole-resistant Fasciola hepatica.

1 reference

https://api.crossref.org/works/10.1007%2FS00436-011-2304-9

21 January 2018

The effect of the hydrogen ionophore closantel upon the pharmacology and ultrastructure of the adult liver fluke Fasciola hepatica

1 reference

https://api.crossref.org/works/10.1007%2FS00436-011-2304-9

21 January 2018

The effect of the sulphoxide metabolite of triclabendazole ('Fasinex') on the tegument of mature and immature stages of the liver fluke, Fasciola hepatica

1 reference

https://api.crossref.org/works/10.1007%2FS00436-011-2304-9

21 January 2018

A scanning electron microscope study on the route of entry of triclabendazole into the liver fluke, Fasciola hepatica

1 reference

https://api.crossref.org/works/10.1007%2FS00436-011-2304-9

21 January 2018

A transmission electron microscope study on the route of entry of triclabendazole into the liver fluke, Fasciola hepatica

1 reference

https://api.crossref.org/works/10.1007%2FS00436-011-2304-9

21 January 2018

Time-dependent changes to the tegumental system and gastrodermis of adult Fasciola hepatica following treatment in vivo with triclabendazole in the sheep host

1 reference

https://api.crossref.org/works/10.1007%2FS00436-011-2304-9

21 January 2018

Inhibition of cytochrome P450 activity enhances the systemic availability of triclabendazole metabolites in sheep

1 reference

https://api.crossref.org/works/10.1007%2FS00436-011-2304-9

21 January 2018

Interaction of common azole antifungals with P glycoprotein

1 reference

https://api.crossref.org/works/10.1007%2FS00436-011-2304-9

21 January 2018

Development of an in vivo preclinical screen model to estimate absorption and first-pass hepatic extraction of xenobiotics. II. Use of ketoconazole to identify P-glycoprotein/CYP3A-limited bioavailability in the monkey

1 reference

https://api.crossref.org/works/10.1007%2FS00436-011-2304-9

21 January 2018

In vitro antimalarial interactions between mefloquine and cytochrome P450 inhibitors

1 reference

https://api.crossref.org/works/10.1007%2FS00436-011-2304-9

21 January 2018

Drug resistance in veterinary helminths

1 reference

https://api.crossref.org/works/10.1007%2FS00436-011-2304-9

21 January 2018

Ivermectin resistance in nematodes may be caused by alteration of P-glycoprotein homolog

1 reference

https://api.crossref.org/works/10.1007%2FS00436-011-2304-9

21 January 2018

Inhibition of cytochromes P450 by antifungal imidazole derivatives

1 reference

https://api.crossref.org/works/10.1007%2FS00436-011-2304-9

21 January 2018

Methimazole-mediated enhancement of albendazole oral bioavailability and anthelmintic effects against parenteral stages of Trichinella spiralis in mice: the influence of the dose-regime

1 reference

https://pubmed.ncbi.nlm.nih.gov/21442257

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

ABC transporters and beta-tubulin in macrocyclic lactone resistance: prospects for marker development

1 reference

https://pubmed.ncbi.nlm.nih.gov/21442257

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Changes to oxfendazole chiral kinetics and anthelmintic efficacy induced by piperonyl butoxide in horses.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21442257

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The kinetics of triclabendazole disposition in sheep

1 reference

https://pubmed.ncbi.nlm.nih.gov/21442257

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Multiple oral dosing of ketoconazole increases dog exposure to ivermectin

1 reference

https://pubmed.ncbi.nlm.nih.gov/21442257

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Fasciola hepatica: Basal infolds and associated vacuoles of the tegument

1 reference

https://pubmed.ncbi.nlm.nih.gov/21442257

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ketoconazole effectively reverses multidrug resistance in highly resistant KB cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/21442257

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Assessment of the main metabolism pathways for the flukicidal compound triclabendazole in sheep

1 reference

https://pubmed.ncbi.nlm.nih.gov/21442257

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interaction between Fenbendazole and Piperonyl Butoxide: Pharmacokinetic and Pharmacodynamic Implications

1 reference

https://pubmed.ncbi.nlm.nih.gov/21442257

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Fasciola hepatica: tegumental alterations as a consequence of lectin binding

1 reference

https://pubmed.ncbi.nlm.nih.gov/21442257

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Influence on the antithyroid compound methimazole on the plasma disposition of fenbendazole and oxfendazole in sheep

1 reference

https://pubmed.ncbi.nlm.nih.gov/21442257

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cytochrome P450 inhibitors. Evaluation of specificities in the in vitrometabolism of therapeutic agents by human liver microsomes

1 reference

https://pubmed.ncbi.nlm.nih.gov/21442257

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Enhancement of triclabendazole action in vivo against a triclabendazole-resistant isolate of Fasciola hepatica by co-treatment with ketoconazole

1 reference

https://pubmed.ncbi.nlm.nih.gov/21442257

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Liver fluke isolates: a question of provenance

1 reference

https://pubmed.ncbi.nlm.nih.gov/21442257

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of ketoconazole on the intestinal metabolism, transport and oral bioavailability of K02, a novel vinylsulfone peptidomimetic cysteine protease inhibitor and a P450 3A, P-glycoprotein dual substrate, in male Sprague-Dawley rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/21442257

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cytochrome P450 isoform inhibitors as a tool for the investigation of metabolic reactions catalyzed by human liver microsomes

1 reference

https://pubmed.ncbi.nlm.nih.gov/21442257

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The interaction between the deacetylated (amine) metabolite of diamphenethide (DAMD) and cytochemically demonstrable Na+/K+-ATPase activity in the tegument of Fasciola hepatica

1 reference

https://pubmed.ncbi.nlm.nih.gov/21442257

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1007/S00436-011-2304-9

1 reference

Europe PubMed Central

PubMed publication ID

1 November 2017

Dimensions Publication ID

0 references

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

1 November 2017

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