(Q42508996)

1 November 2017

title

Insulin growth factor receptor-1 expression and loss of PTEN protein predict early recurrence in triple-negative breast cancer (English)

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1 November 2017

Jabed Iqbal

1

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1 November 2017

Aye Aye Thike

2

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1 November 2017

Poh Yian Cheok

3

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1 November 2017

Gary Man-Kit Tse

4

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1 November 2017

Puay Hoon Tan

5

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1 November 2017

publication date

1 October 2012

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1 November 2017

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1 November 2017

volume

61

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1 November 2017

issue

4

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1 November 2017

page(s)

652-659

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Reduced PTEN expression in breast cancer cells confers susceptibility to inhibitors of the PI3 kinase/Akt pathway

1 November 2017

cites work

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Divergent effects of insulin-like growth factor-1 receptor expression on prognosis of estrogen receptor positive versus triple negative invasive ductal breast carcinoma.

21 January 2018

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Insulin-like growth factor-I activates gene transcription programs strongly associated with poor breast cancer prognosis

21 January 2018

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Increased phosphorylation of Akt in triple-negative breast cancers

21 January 2018

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The Akt pathway in human breast cancer: a tissue-array-based analysis

21 January 2018

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Frequent PTEN genomic alterations and activated phosphatidylinositol 3-kinase pathway in basal-like breast cancer cells

21 January 2018

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Type I insulin-like growth factor receptor as a therapeutic target in cancer

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AKT activity determines sensitivity to mammalian target of rapamycin (mTOR) inhibitors by regulating cyclin D1 and c-myc expression

21 January 2018

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Subcellular localization of activated AKT in estrogen receptor- and progesterone receptor-expressing breast cancers: potential clinical implications

21 January 2018

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New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway

21 January 2018

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Triple-negative breast cancer: clinicopathological characteristics and relationship with basal-like breast cancer

21 January 2018

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Essential role for nuclear PTEN in maintaining chromosomal integrity

21 January 2018

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Loss of Phosphatase and Tensin homologue deleted on chromosome 10 engages ErbB3 and insulin-like growth factor-I receptor signaling to promote antiestrogen resistance in breast cancer

21 January 2018

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Loss of expression of the PTEN gene protein product is associated with poor outcome in breast cancer

21 January 2018

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Dysregulated PTEN-PKB and negative receptor status in human breast cancer

21 January 2018

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Up-regulation of Akt3 in estrogen receptor-deficient breast cancers and androgen-independent prostate cancer lines.

21 January 2018

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Suppression of PTEN function increases breast cancer chemotherapeutic drug resistance while conferring sensitivity to mTOR inhibitors.

21 January 2018

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Triple negative breast cancer: outcome correlation with immunohistochemical detection of basal markers

21 January 2018

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Reduced PTEN expression predicts relapse in patients with breast carcinoma treated by tamoxifen

21 January 2018

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High IGF-IR activity in triple-negative breast cancer cell lines and tumorgrafts correlates with sensitivity to anti-IGF-IR therapy

21 January 2018

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Prognostic markers in triple-negative breast cancer

21 January 2018

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IMC-A12, a human IgG1 monoclonal antibody to the insulin-like growth factor I receptor

21 January 2018

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Poor prognosis in carcinoma is associated with a gene expression signature of aberrant PTEN tumor suppressor pathway activity.

21 January 2018

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PTEN activation contributes to tumor inhibition by trastuzumab, and loss of PTEN predicts trastuzumab resistance in patients.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2559.2012.04255.X

Dysregulated PI3K/Akt/PTEN pathway is a marker of a short disease-free survival in node-negative breast carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2559.2012.04255.X

Insulin-like growth factor 1 receptor targeted therapeutics: novel compounds and novel treatment strategies for cancer medicine

21 January 2018

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Defining the role of mTOR in cancer

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1365-2559.2012.04255.X

Tenets of PTEN tumor suppression

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1365-2559.2012.04255.X

10.1111/J.1365-2559.2012.04255.X

21 January 2018

Identifiers

DOI

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1 November 2017

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