(Q42525511)

1 November 2017

Akt blockade downregulates collagen and upregulates MMP1 in human dermal fibroblasts (English)

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1 November 2017

6

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1 November 2017

Andreea M Bujor

1

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author name string

Jaspreet Pannu

2

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1 November 2017

Shizhong Bu

3

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1 November 2017

Edwin A Smith

4

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1 November 2017

Robin C Muise-Helmericks

5

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1 November 2017

language of work or name

English

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publication date

6 March 2008

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Journal of Investigative Dermatology

1 November 2017

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1 November 2017

128

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1 November 2017

1906-1914

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1 November 2017

8

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https://scigraph.springernature.com/pub.10.1038/jid.2008.39

1 November 2017

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cites work

Preliminary criteria for the classification of systemic sclerosis (scleroderma)

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7 January 2021

Phosphatidylinositol 3-kinase is involved in alpha2(I) collagen gene expression in normal and scleroderma fibroblasts

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https://api.crossref.org/works/10.1038%2FJID.2008.39

7 January 2021

Phosphatidylinositol 3-kinase function is required for transforming growth factor beta-mediated epithelial to mesenchymal transition and cell migration.

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https://api.crossref.org/works/10.1038%2FJID.2008.39

7 January 2021

Akt activation by growth factors is a multiple-step process: the role of the PH domain

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https://api.crossref.org/works/10.1038%2FJID.2008.39

7 January 2021

Akt1 regulates pathological angiogenesis, vascular maturation and permeability in vivo

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https://api.crossref.org/works/10.1038%2FJID.2008.39

7 January 2021

Stimulation of Type I Collagen Transcription in Human Skin Fibroblasts by TGF-β: Involvement of Smad 3

1 reference

https://api.crossref.org/works/10.1038%2FJID.2008.39

7 January 2021

Growth retardation and increased apoptosis in mice with homozygous disruption of the Akt1 gene

1 reference

https://api.crossref.org/works/10.1038%2FJID.2008.39

7 January 2021

Contribution of activin receptor-like kinase 5 (transforming growth factor beta receptor type I) signaling to the fibrotic phenotype of scleroderma fibroblasts

1 reference

https://api.crossref.org/works/10.1038%2FJID.2008.39

7 January 2021

Rho activation is required for transforming growth factor-beta-induced epithelial-mesenchymal transition in lens epithelial cells

1 reference

https://api.crossref.org/works/10.1038%2FJID.2008.39

7 January 2021

How is Type I procollagen synthesis regulated at the gene level during tissue fibrosis

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https://api.crossref.org/works/10.1038%2FJID.2008.39

7 January 2021

Smad-dependent and Smad-independent pathways in TGF-beta family signalling

1 reference

https://api.crossref.org/works/10.1038%2FJID.2008.39

7 January 2021

Life with a single isoform of Akt: mice lacking Akt2 and Akt3 are viable but display impaired glucose homeostasis and growth deficiencies

1 reference

https://api.crossref.org/works/10.1038%2FJID.2008.39

7 January 2021

Autocrine transforming growth factor-beta signaling mediates Smad-independent motility in human cancer cells.

1 reference

https://api.crossref.org/works/10.1038%2FJID.2008.39

7 January 2021

Proteasome blockade exerts an antifibrotic activity by coordinately down-regulating type I collagen and tissue inhibitor of metalloproteinase-1 and up-regulating metalloproteinase-1 production in human dermal fibroblasts

1 reference

https://api.crossref.org/works/10.1038%2FJID.2008.39

7 January 2021

Smad3 as a mediator of the fibrotic response

1 reference

https://api.crossref.org/works/10.1038%2FJID.2008.39

7 January 2021

Proteasome inhibitor bortezomib increases PTEN expression and enhances trastuzumab-induced growth inhibition in trastuzumab-resistant cells.

1 reference

https://api.crossref.org/works/10.1038%2FJID.2008.39

7 January 2021

The role of p70S6K in hepatic stellate cell collagen gene expression and cell proliferation

1 reference

https://api.crossref.org/works/10.1038%2FJID.2008.39

7 January 2021

Severe diabetes, age-dependent loss of adipose tissue, and mild growth deficiency in mice lacking Akt2/PKB beta

1 reference

https://api.crossref.org/works/10.1038%2FJID.2008.39

7 January 2021

Insulin-like growth factor 1 blocks collagen release and down regulates matrix metalloproteinase-1, -3, -8, and -13 mRNA expression in bovine nasal cartilage stimulated with oncostatin M in combination with interleukin 1alpha

1 reference

https://api.crossref.org/works/10.1038%2FJID.2008.39

7 January 2021

Transcriptional Regulation of the Human α2(I) Collagen Gene

1 reference

https://api.crossref.org/works/10.1038%2FJID.2008.39

7 January 2021

Inhibitory Effects of Insulin-like Growth Factor-1 and Osteogenic Protein-1 on Fibronectin Fragment- and Interleukin-1β-stimulated Matrix Metalloproteinase-13 Expression in Human Chondrocytes

1 reference

https://api.crossref.org/works/10.1038%2FJID.2008.39

7 January 2021

Role of apoptosis and transforming growth factor beta1 in fibroblast selection and activation in systemic sclerosis

1 reference

https://api.crossref.org/works/10.1038%2FJID.2008.39

7 January 2021

Role of protein kinase C-delta in the regulation of collagen gene expression in scleroderma fibroblasts

1 reference

https://api.crossref.org/works/10.1038%2FJID.2008.39

7 January 2021

Scleroderma fibroblasts demonstrate enhanced activation of Akt (protein kinase B) in situ.

1 reference

https://api.crossref.org/works/10.1038%2FJID.2008.39

7 January 2021

Increased Expression of TGF-β Receptors by Scleroderma Fibroblasts: Evidence for Contribution of Autocrine TGF-β Signaling to Scleroderma Phenotype

1 reference

https://api.crossref.org/works/10.1038%2FJID.2008.39

7 January 2021

Akt: versatile mediator of cell survival and beyond

1 reference

https://api.crossref.org/works/10.1038%2FJID.2008.39

7 January 2021

Necessary role of phosphatidylinositol 3-kinase in transforming growth factor beta-mediated activation of Akt in normal and rheumatoid arthritis synovial fibroblasts

1 reference

https://api.crossref.org/works/10.1038%2FJID.2008.39

7 January 2021

Myofibroblasts from scleroderma skin synthesize elevated levels of collagen and tissue inhibitor of metalloproteinase (TIMP-1) with two forms of TIMP-1.

1 reference

https://api.crossref.org/works/10.1038%2FJID.2008.39

7 January 2021

Akt mediates mechanical strain-induced collagen production by mesangial cells

1 reference

https://api.crossref.org/works/10.1038%2FJID.2008.39

7 January 2021

Novel fibrogenic pathways are activated in response to endothelial apoptosis: implications in the pathophysiology of systemic sclerosis

1 reference

https://api.crossref.org/works/10.1038%2FJID.2008.39

7 January 2021

Expression and regulation of intracellular SMAD signaling in scleroderma skin fibroblasts

1 reference

https://api.crossref.org/works/10.1038%2FJID.2008.39

7 January 2021

Increased levels of transforming growth factor beta receptor type I and up-regulation of matrix gene program: A model of scleroderma.

1 reference

https://api.crossref.org/works/10.1038%2FJID.2008.39

7 January 2021

An increased transforming growth factor beta receptor type I:type II ratio contributes to elevated collagen protein synthesis that is resistant to inhibition via a kinase-deficient transforming growth factor beta receptor type II in scleroderma

1 reference

https://api.crossref.org/works/10.1038%2FJID.2008.39

7 January 2021

Transforming growth factor-beta receptor type I-dependent fibrogenic gene program is mediated via activation of Smad1 and ERK1/2 pathways.

1 reference

https://api.crossref.org/works/10.1038%2FJID.2008.39

7 January 2021

Modulation of collagen and MMP-1 gene expression in fibroblasts by the immunosuppressive drug rapamycin. A direct role as an antifibrotic agent?

1 reference

https://api.crossref.org/works/10.1038%2FJID.2008.39

7 January 2021

The role of focal adhesion kinase-phosphatidylinositol 3-kinase-akt signaling in hepatic stellate cell proliferation and type I collagen expression

1 reference

https://api.crossref.org/works/10.1038%2FJID.2008.39

7 January 2021

Phosphatidylinositol 3-kinase-dependent stabilization of alpha1(I) collagen mRNA in human lung fibroblasts

1 reference

https://api.crossref.org/works/10.1038%2FJID.2008.39

7 January 2021

The Phosphatidylinositol 3-Kinase/Akt Pathway Enhances Smad3-stimulated Mesangial Cell Collagen I Expression in Response to Transforming Growth Factor-β1

1 reference

https://api.crossref.org/works/10.1038%2FJID.2008.39

7 January 2021

Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex

1 reference

https://api.crossref.org/works/10.1038%2FJID.2008.39

7 January 2021

Mammalian target of rapamycin positively regulates collagen type I production via a phosphatidylinositol 3-kinase-independent pathway

1 reference

https://api.crossref.org/works/10.1038%2FJID.2008.39

7 January 2021

Decreased collagenase expression in cultured systemic sclerosis fibroblasts

1 reference

https://api.crossref.org/works/10.1038%2FJID.2008.39

7 January 2021

Essential role of protein kinase B gamma (PKB gamma/Akt3) in postnatal brain development but not in glucose homeostasis

1 reference

https://api.crossref.org/works/10.1038%2FJID.2008.39

7 January 2021

Systemic sclerosis: a prototypic multisystem fibrotic disorder

1 reference

https://api.crossref.org/works/10.1038%2FJID.2008.39

7 January 2021

Modulation of prosurvival signaling in fibroblasts by a protein kinase inhibitor protects against fibrotic tissue injury.

1 reference

https://api.crossref.org/works/10.1038%2FJID.2008.39

7 January 2021

Imatinib mesylate blocks a non-Smad TGF-beta pathway and reduces renal fibrogenesis in vivo

1 reference

https://api.crossref.org/works/10.1038%2FJID.2008.39

7 January 2021

Proteasome inhibition down-regulates endothelial nitric-oxide synthase phosphorylation and function

1 reference

https://api.crossref.org/works/10.1038%2FJID.2008.39

7 January 2021

Transforming growth factor beta activation of c-Abl is independent of receptor internalization and regulated by phosphatidylinositol 3-kinase and PAK2 in mesenchymal cultures

1 reference

https://api.crossref.org/works/10.1038%2FJID.2008.39

7 January 2021

Transforming growth factor-beta activation of phosphatidylinositol 3-kinase is independent of Smad2 and Smad3 and regulates fibroblast responses via p21-activated kinase-2

1 reference

https://api.crossref.org/works/10.1038%2FJID.2008.39

7 January 2021

Collagen I induction by high glucose levels is mediated by epidermal growth factor receptor and phosphoinositide 3-kinase/Akt signalling in mesangial cells

1 reference

https://api.crossref.org/works/10.1038%2FJID.2008.39

7 January 2021

Increased transcriptional activities of transforming growth factor beta receptors in scleroderma fibroblasts

1 reference

https://api.crossref.org/works/10.1038%2FJID.2008.39

7 January 2021

Physiological functions of protein kinase B/Akt

1 reference

https://api.crossref.org/works/10.1038%2FJID.2008.39

7 January 2021

Type I transforming growth factor beta receptor binds to and activates phosphatidylinositol 3-kinase.

1 reference

https://api.crossref.org/works/10.1038%2FJID.2008.39

7 January 2021

The crucial role of TGF-beta in the age-related alterations induced by ultraviolet A irradiation

1 reference

https://api.crossref.org/works/10.1038%2FJID.2008.39

7 January 2021

Transforming growth factor-beta repression of matrix metalloproteinase-1 in dermal fibroblasts involves Smad3.

1 reference

https://api.crossref.org/works/10.1038%2FJID.2008.39

7 January 2021

Identifiers

DOI

10.1038/JID.2008.39

1 reference

1 November 2017

1 reference