(Q42537068)

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Bifunctional inhibition of human immunodeficiency virus type 1 reverse transcriptase: mechanism and proof-of-concept as a novel therapeutic design strategy

scientific article published on 9 May 2013

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scholarly article

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Europe PubMed Central

PMC publication ID

1 November 2017

Bifunctional inhibition of human immunodeficiency virus type 1 reverse transcriptase: mechanism and proof-of-concept as a novel therapeutic design strategy (English)

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Europe PubMed Central

PMC publication ID

1 November 2017

Christopher M Bailey

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Christopher M Bailey

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Roger Hunter

9

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William L. Jorgensen

8

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William L Jorgensen

1 reference

Europe PubMed Central

1 November 2017

PMC publication ID

3

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Pinar Iyidogan

1 reference

Europe PubMed Central

PMC publication ID

1 November 2017

Julian Tirado-Rives

4

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Julian Tirado-Rives

1 reference

Europe PubMed Central

1 November 2017

PMC publication ID

Juliana Ruiz-Caro

6

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Juliana Ruiz-Caro

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Europe PubMed Central

1 November 2017

PMC publication ID

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Todd J Sullivan

2

1 reference

Europe PubMed Central

PMC publication ID

1 November 2017

Raymond Chung

5

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Europe PubMed Central

PMC publication ID

1 November 2017

Ebrahim Mohamed

7

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Europe PubMed Central

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1 November 2017

Karen S Anderson

10

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Europe PubMed Central

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1 November 2017

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publication date

9 May 2013

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Europe PubMed Central

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1 November 2017

Journal of Medicinal Chemistry

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Europe PubMed Central

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1 November 2017

56

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Europe PubMed Central

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1 November 2017

10

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Europe PubMed Central

PMC publication ID

1 November 2017

3959-3968

1 reference

Europe PubMed Central

PMC publication ID

1 November 2017

Bifunctional inhibition of HIV-1 reverse transcriptase: a first step in designing a bifunctional triphosphate

1 reference

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28 May 2018

Understanding the molecular mechanism of sequence dependent tenofovir removal by HIV-1 reverse transcriptase: differences in primer binding site versus polypurine tract

1 reference

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28 May 2018

HIV-1 RT Inhibitors with a Novel Mechanism of Action: NNRTIs that Compete with the Nucleotide Substrate

1 reference

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28 May 2018

Pre-steady-state kinetic analysis of the incorporation of anti-HIV nucleotide analogs catalyzed by human X- and Y-family DNA polymerases

1 reference

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28 May 2018

Nucleoside reverse transcriptase inhibitor toxicity and mitochondrial DNA

1 reference

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28 May 2018

[d4U]-spacer-[HI-236] double-drug inhibitors of HIV-1 reverse-transcriptase.

1 reference

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28 May 2018

A mechanistic view of human mitochondrial DNA polymerase gamma: providing insight into drug toxicity and mitochondrial disease

1 reference

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28 May 2018

Molecular basis of human immunodeficiency virus drug resistance: an update.

1 reference

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28 May 2018

Structure and function of HIV-1 reverse transcriptase: molecular mechanisms of polymerization and inhibition

1 reference

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28 May 2018

Polymeric nanogels containing the triphosphate form of cytotoxic nucleoside analogues show antitumor activity against breast and colorectal cancer cell lines

1 reference

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28 May 2018

High-resolution structures of HIV-1 reverse transcriptase/TMC278 complexes: strategic flexibility explains potency against resistance mutations

1 reference

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28 May 2018

[d4U]-butyne-[HI-236] as a non-cleavable, bifunctional NRTI/NNRTI HIV-1 reverse-transcriptase inhibitor

1 reference

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28 May 2018

Polyplex Nanogel formulations for drug delivery of cytotoxic nucleoside analogs.

1 reference

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28 May 2018

In search of a novel anti-HIV drug: multidisciplinary coordination in the discovery of 4-[[4-[[4-[(1E)-2-cyanoethenyl]-2,6-dimethylphenyl]amino]-2- pyrimidinyl]amino]benzonitrile (R278474, rilpivirine).

1 reference

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28 May 2018

UCSF Chimera--a visualization system for exploratory research and analysis

1 reference

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28 May 2018

Dynamics of HIV-1 recombination in its natural target cells

1 reference

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28 May 2018

Defining a molecular mechanism of synergy between nucleoside and nonnucleoside AIDS drugs.

1 reference

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28 May 2018

High rates of human immunodeficiency virus type 1 recombination: near-random segregation of markers one kilobase apart in one round of viral replication

1 reference

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28 May 2018

Synthesis of 5-alkenylated D4T analogues via the Pd-catalyzed cross-coupling reaction

1 reference

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28 May 2018

Synthesis and antiviral activity of C-5 substituted beta-D- and beta-L-D4T analogues

1 reference

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28 May 2018

Synthesis and evaluation of "AZT-HEPT", "AZT-pyridinone", and "ddC-HEPT" conjugates as inhibitors of HIV reverse transcriptase

1 reference

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28 May 2018

Mechanism of inhibition of the human immunodeficiency virus type 1 reverse transcriptase by d4TTP: an equivalent incorporation efficiency relative to the natural substrate dTTP

1 reference

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28 May 2018

Potential multifunctional inhibitors of HIV-1 reverse transcriptase. Novel [AZT]-[TSAO-T] and [d4T]-[TSAO-T] heterodimers modified in the linker and in the dideoxynucleoside region

1 reference

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28 May 2018

Synthesis of novel C-5 substituted d4T analogues bearing linker arms as potential anti-HIV agents

1 reference

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28 May 2018

Imidazo[1,5-b]pyridazine-d4T conjugates: synthesis and anti-human immunodeficiency virus evaluation

1 reference

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28 May 2018

Structure of a covalently trapped catalytic complex of HIV-1 reverse transcriptase: implications for drug resistance

1 reference

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Pre-steady-state kinetic characterization of wild type and 3'-azido-3'-deoxythymidine (AZT) resistant human immunodeficiency virus type 1 reverse transcriptase: implication of RNA directed DNA polymerization in the mechanism of AZT resistance

1 reference

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Structure of unliganded HIV-1 reverse transcriptase at 2.7 A resolution: implications of conformational changes for polymerization and inhibition mechanisms

1 reference

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HIV-1 dynamics in vivo: virion clearance rate, infected cell life-span, and viral generation time

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HIV population dynamics in vivo: implications for genetic variation, pathogenesis, and therapy

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28 May 2018

Structure of HIV-1 RT/TIBO R 86183 complex reveals similarity in the binding of diverse nonnucleoside inhibitors

1 reference

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28 May 2018

Human immunodeficiency virus reverse transcriptase substrate-induced conformational changes and the mechanism of inhibition by nonnucleoside inhibitors

1 reference

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28 May 2018

Synthesis and anti-HIV activity of [AZT]-[TSAO-T] and [AZT]-[HEPT] dimers as potential multifunctional inhibitors of HIV-1 reverse transcriptase.

1 reference

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Structure of the binding site for nonnucleoside inhibitors of the reverse transcriptase of human immunodeficiency virus type 1

1 reference

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1 reference

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Mechanism of inhibition of HIV-1 reverse transcriptase by nonnucleoside inhibitors.

1 reference

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1 reference

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1 reference

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Molecular insights into NRTI inhibition and mitochondrial toxicity revealed from a structural model of the human mitochondrial DNA polymerase.

1 reference

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Validation of a model for the complex of HIV-1 reverse transcriptase with nonnucleoside inhibitor TMC125.

1 reference

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Syntheses of nucleoside triphosphates

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Retrovirus mutation rates and their role in genetic variation

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based on heuristic

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Characterization of novel reverse transcriptase and other RNA-associated catalytic activities by human DNA polymerase gamma: importance in mitochondrial DNA replication

1 reference

https://pubmed.ncbi.nlm.nih.gov/23659183

12 December 2020

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inferred from PubMed ID database lookup

Studies on aromatase inhibitors. III. Synthesis and biological evaluation of [(4-bromobenzyl)(4-cyanophenyl)amino]azoles and their azine analogs

1 reference

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1021/JM400160S

1 reference

Europe PubMed Central

PMC publication ID

1 November 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

1 November 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

1 November 2017

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