(Q42559350)

2 November 2017

Five siRNAs targeting three SNPs may provide therapy for three-quarters of Huntington's disease patients (English)

1 reference

2 November 2017

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Bernhard Landwehrmeyer

7

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2 November 2017

Phillip D Zamore

9

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author name string

Edith L Pfister

1

1 reference

2 November 2017

Lori Kennington

2

1 reference

2 November 2017

Juerg Straubhaar

3

1 reference

2 November 2017

Sujata Wagh

4

1 reference

2 November 2017

Wanzhou Liu

5

1 reference

2 November 2017

Marian DiFiglia

6

1 reference

2 November 2017

Jean-Paul Vonsattel

8

1 reference

2 November 2017

Neil Aronin

10

1 reference

2 November 2017

language of work or name

English

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publication date

9 April 2009

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2 November 2017

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2 November 2017

19

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2 November 2017

9

1 reference

2 November 2017

774-778

1 reference

Linking SNPs to CAG repeat length in Huntington's disease patients.

2 November 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2746439

Enhancement of allele discrimination by introduction of nucleotide mismatches into siRNA in allele-specific gene silencing by RNAi

28 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2746439

Analysis of siRNA specificity on targets with double-nucleotide mismatches

28 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2746439

Therapeutic silencing of mutant huntingtin with siRNA attenuates striatal and cortical neuropathology and behavioral deficits

28 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2746439

Designing siRNA that distinguish between genes that differ by a single nucleotide

28 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2746439

Determinants of specific RNA interference-mediated silencing of human beta-globin alleles differing by a single nucleotide polymorphism

28 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2746439

Normal huntingtin function: an alternative approach to Huntington's disease

28 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2746439

Clinico-pathological rescue of a model mouse of Huntington's disease by siRNA.

28 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2746439

RNA interference improves motor and neuropathological abnormalities in a Huntington's disease mouse model

28 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2746439

A systematic analysis of the silencing effects of an active siRNA at all single-nucleotide mismatched target sites

28 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2746439

A SNP-centric database for the investigation of the human genome

28 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2746439

Targeting Alzheimer's disease genes with RNA interference: an efficient strategy for silencing mutant alleles

28 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2746439

Selective silencing by RNAi of a dominant allele that causes amyotrophic lateral sclerosis

28 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2746439

siRNA-mediated gene silencing in vitro and in vivo.

28 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2746439

Rescue of polyglutamine-mediated cytotoxicity by double-stranded RNA-mediated RNA interference

28 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2746439

Inactivation of Hdh in the brain and testis results in progressive neurodegeneration and sterility in mice

28 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2746439

A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes.

28 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2746439

Identification and allele-specific silencing of the mutant huntingtin allele in Huntington's disease patient-derived fibroblasts.

28 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2746439

Allele-specific RNAi selectively silences mutant SOD1 and achieves significant therapeutic benefit in vivo.

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2746439

rAAV-mediated shRNA ameliorated neuropathology in Huntington disease model mouse

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2746439

Silencing mutant SOD1 using RNAi protects against neurodegeneration and extends survival in an ALS model

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2746439

Lentiviral-mediated silencing of SOD1 through RNA interference retards disease onset and progression in a mouse model of ALS.

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2746439

RNAi suppresses polyglutamine-induced neurodegeneration in a model of spinocerebellar ataxia.

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2746439

SNPper: retrieval and analysis of human SNPs.

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2746439

The HD mutation causes progressive lethal neurological disease in mice expressing reduced levels of huntingtin.

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2746439

10.1016/J.CUB.2009.03.030

16 August 2018

Identifiers

DOI

1 reference

2 November 2017

1 reference

2 November 2017

1 reference