(Q42601309)

English

Hydrogen exchange mass spectrometry reveals protein interfaces and distant dynamic coupling effects during the reversible self-association of an IgG1 monoclonal antibody

scientific article published on January 2015

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

3 November 2017

Hydrogen exchange mass spectrometry reveals protein interfaces and distant dynamic coupling effects during the reversible self-association of an IgG1 monoclonal antibody (English)

1 reference

Europe PubMed Central

PMC publication ID

3 November 2017

object named as

Jayant Arora

1

0 references

object named as

David D Weis

8

0 references

author name string

John M Hickey

2

1 reference

Europe PubMed Central

PMC publication ID

3 November 2017

Ranajoy Majumdar

3

1 reference

Europe PubMed Central

PMC publication ID

3 November 2017

Reza Esfandiary

4

1 reference

Europe PubMed Central

PMC publication ID

3 November 2017

Steven M Bishop

5

1 reference

Europe PubMed Central

PMC publication ID

3 November 2017

Hardeep S Samra

6

1 reference

Europe PubMed Central

PMC publication ID

3 November 2017

C Russell Middaugh

7

1 reference

Europe PubMed Central

PMC publication ID

3 November 2017

David B Volkin

9

1 reference

Europe PubMed Central

PMC publication ID

3 November 2017

publication date

1 January 2015

1 reference

Europe PubMed Central

PMC publication ID

3 November 2017

Monoclonal Antibodies

1 reference

Europe PubMed Central

PMC publication ID

3 November 2017

7

1 reference

Europe PubMed Central

PMC publication ID

3 November 2017

3

1 reference

Europe PubMed Central

PMC publication ID

3 November 2017

525-539

1 reference

Europe PubMed Central

PMC publication ID

3 November 2017

Correlations between changes in conformational dynamics and physical stability in a mutant IgG1 mAb engineered for extended serum half-life

1 reference

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Hydrogen-deuterium exchange mass spectrometry as an emerging analytical tool for stabilization and formulation development of therapeutic monoclonal antibodies

1 reference

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Improving monoclonal antibody selection and engineering using measurements of colloidal protein interactions

1 reference

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The ensemble nature of allostery

1 reference

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Multisteric regulation by structural disorder in modular signaling proteins: an extension of the concept of allostery

1 reference

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28 May 2018

A unified view of "how allostery works"

1 reference

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Investigating monoclonal antibody aggregation using a combination of H/DX-MS and other biophysical measurements

1 reference

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Allostery in disease and in drug discovery

1 reference

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28 May 2018

Do clustering monoclonal antibody solutions really have a concentration dependence of viscosity?

1 reference

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28 May 2018

The role of amino acid sequence in the self-association of therapeutic monoclonal antibodies: insights from coarse-grained modeling

1 reference

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28 May 2018

Structural analysis of a therapeutic monoclonal antibody dimer by hydroxyl radical footprinting

1 reference

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28 May 2018

Conformational characterization of the charge variants of a human IgG1 monoclonal antibody using H/D exchange mass spectrometry

1 reference

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28 May 2018

Mechanisms of self-association of a human monoclonal antibody CNTO607.

1 reference

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28 May 2018

Weak interactions govern the viscosity of concentrated antibody solutions: high-throughput analysis using the diffusion interaction parameter

1 reference

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28 May 2018

Probing protein interactions with hydrogen/deuterium exchange and mass spectrometry-a review

1 reference

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28 May 2018

High-throughput analysis of concentration-dependent antibody self-association.

1 reference

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28 May 2018

The utility of hydrogen/deuterium exchange mass spectrometry in biopharmaceutical comparability studies

1 reference

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28 May 2018

A new approach to explore the impact of freeze-thaw cycling on protein structure: hydrogen/deuterium exchange mass spectrometry (HX-MS).

1 reference

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28 May 2018

Comparative Effects of pH and Ionic Strength on Protein–Protein Interactions, Unfolding, and Aggregation for IgG1 Antibodies

1 reference

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28 May 2018

Discovery and characterization of the laulimalide-microtubule binding mode by mass shift perturbation mapping

1 reference

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28 May 2018

Phase separation of an IgG1 antibody solution under a low ionic strength condition

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4622866

28 May 2018

Conformational changes in oxidatively stressed monoclonal antibodies studied by hydrogen exchange mass spectrometry

1 reference

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28 May 2018

Post-translational modifications differentially affect IgG1 conformation and receptor binding.

1 reference

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28 May 2018

mAbs: a business perspective

1 reference

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28 May 2018

Analysis of protein conformation and dynamics by hydrogen/deuterium exchange MS.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4622866

28 May 2018

Mechanisms of protein aggregation

1 reference

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28 May 2018

Nature and consequences of protein-protein interactions in high protein concentration solutions

1 reference

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28 May 2018

Ultrasonic storage modulus as a novel parameter for analyzing protein-protein interactions in high protein concentration solutions: correlation with static and dynamic light scattering measurements

1 reference

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Analytical ultracentrifugation for the study of protein association and assembly

1 reference

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Ligand-induced conformational changes in the acetylcholine-binding protein analyzed by hydrogen-deuterium exchange mass spectrometry

1 reference

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28 May 2018

Composition gradient static light scattering: a new technique for rapid detection and quantitative characterization of reversible macromolecular hetero-associations in solution.

1 reference

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Protein self-association induced by macromolecular crowding: a quantitative analysis by magnetic relaxation dispersion

1 reference

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28 May 2018

Challenges in the development of high protein concentration formulations

1 reference

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Electrospray ionization-mass spectrometry and tandem mass spectrometry reveal self-association and metal-ion binding of hydrophobic peptides: a study of the gramicidin dimer

1 reference

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Protein self-association in solution: the bovine pancreatic trypsin inhibitor decamer

1 reference

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28 May 2018

Crystal structure of a neutralizing human IGG against HIV-1: a template for vaccine design

1 reference

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28 May 2018

The influence of macromolecular crowding and macromolecular confinement on biochemical reactions in physiological media

1 reference

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28 May 2018

Implications of macromolecular crowding for protein assembly.

1 reference

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28 May 2018

Identification of protein-protein interfaces by decreased amide proton solvent accessibility

1 reference

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28 May 2018

Protein interactions in solution characterized by light and neutron scattering: comparison of lysozyme and chymotrypsinogen

1 reference

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28 May 2018

The Hofmeister series: salt and solvent effects on interfacial phenomena

1 reference

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28 May 2018

How Hofmeister ion interactions affect protein stability

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4622866

28 May 2018

Interactions of stabilizing additives with proteins during freeze-thawing and freeze-drying

1 reference

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Action of shear on enzymes: Studies with alcohol dehydrogenase

1 reference

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Mechanism of reversible self-association of a monoclonal antibody: role of electrostatic and hydrophobic interactions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4622866

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1 reference

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Immunoactive two-dimensional self-assembly of monoclonal antibodies in aqueous solution revealed by atomic force microscopy.

1 reference

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1 reference

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1 reference

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Effects of salts from the Hofmeister series on the conformational stability, aggregation propensity, and local flexibility of an IgG1 monoclonal antibody.

1 reference

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Monoclonal antibody self-association, cluster formation, and rheology at high concentrations

1 reference

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Specific ion-protein interactions dictate solubility behavior of a monoclonal antibody at low salt concentrations

1 reference

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1 reference

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1 reference

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Fc domain mediated self-association of an IgG1 monoclonal antibody under a low ionic strength condition

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Solution pH that minimizes self-association of three monoclonal antibodies is strongly dependent on ionic strength

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https://pubmed.ncbi.nlm.nih.gov/25875351

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based on heuristic

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based on heuristic

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Identifiers

10.1080/19420862.2015.1029217

1 reference

Europe PubMed Central

PMC publication ID

3 November 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

3 November 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

3 November 2017

ResearchGate publication ID

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