(Q42617280)

3 November 2017

title

A crucial function of SGT1 and HSP90 in inflammasome activity links mammalian and plant innate immune responses (English)

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3 November 2017

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Jürg Tschopp

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3 November 2017

Annick Mayor

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3 November 2017

Thibaut De Smedt

series ordinal

3

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3 November 2017

language of work or name

English

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publication date

15 April 2007

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3 November 2017

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3 November 2017

volume

8

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3 November 2017

issue

5

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3 November 2017

page(s)

497-503

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The inflammasome: first line of the immune response to cell stress

3 November 2017

cites work

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7 January 2021

Inflammatory caspases and inflammasomes: master switches of inflammation

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7 January 2021

The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta

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7 January 2021

Mutation of a new gene encoding a putative pyrin-like protein causes familial cold autoinflammatory syndrome and Muckle-Wells syndrome

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7 January 2021

Spectrum of clinical features in Muckle-Wells syndrome and response to anakinra

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7 January 2021

Identification of bacterial muramyl dipeptide as activator of the NALP3/cryopyrin inflammasome.

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7 January 2021

Bacterial RNA and small antiviral compounds activate caspase-1 through cryopyrin/Nalp3

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7 January 2021

Cytosolic flagellin requires Ipaf for activation of caspase-1 and interleukin 1beta in salmonella-infected macrophages

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7 January 2021

Cytoplasmic flagellin activates caspase-1 and secretion of interleukin 1beta via Ipaf

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7 January 2021

Gout-associated uric acid crystals activate the NALP3 inflammasome

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7 January 2021

Cryopyrin activates the inflammasome in response to toxins and ATP

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7 January 2021

Critical role for NALP3/CIAS1/Cryopyrin in innate and adaptive immunity through its regulation of caspase-1

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7 January 2021

Targeted disruption of pyrin, the FMF protein, causes heightened sensitivity to endotoxin and a defect in macrophage apoptosis

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7 January 2021

Host-microbe interactions: shaping the evolution of the plant immune response

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7 January 2021

Plant innate immunity - direct and indirect recognition of general and specific pathogen-associated molecules.

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Plant immunity: the origami of receptor activation

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7 January 2021

Resistance gene signaling in plants--complex similarities to animal innate immunity

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7 January 2021

Intracellular pattern recognition receptors in the host response

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7 January 2021

CATERPILLER: a novel gene family important in immunity, cell death, and diseases

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7 January 2021

NOD-LRR proteins: role in host-microbial interactions and inflammatory disease

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7 January 2021

The HSP90 chaperone complex, an emerging force in plant development and phenotypic plasticity

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7 January 2021

Complex formation, promiscuity and multi-functionality: protein interactions in disease-resistance pathways

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The RAR1 interactor SGT1, an essential component of R gene-triggered disease resistance

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Sgt1p is a unique co-chaperone that acts as a client adaptor to link Hsp90 to Skp1p

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7 January 2021

HSP90 interacts with RAR1 and SGT1 and is essential for RPS2-mediated disease resistance in Arabidopsis

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Tetracycline repressor, tetR, rather than the tetR-mammalian cell transcription factor fusion derivatives, regulates inducible gene expression in mammalian cells

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7 January 2021

Recombinase-mediated gene activation and site-specific integration in mammalian cells

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7 January 2021

High throughput virus-induced gene silencing implicates heat shock protein 90 in plant disease resistance.

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7 January 2021

Antagonistic control of disease resistance protein stability in the plant immune system.

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7 January 2021

Regulation of Nod1 by Hsp90 chaperone complex

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7 January 2021

Host recognition of bacterial muramyl dipeptide mediated through NOD2. Implications for Crohn's disease

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7 January 2021

Differential activation of the inflammasome by caspase-1 adaptors ASC and Ipaf

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7 January 2021

The Birc1e cytosolic pattern-recognition receptor contributes to the detection and control of Legionella pneumophila infection

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7 January 2021

Hsp90 inhibitors in the clinic

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7 January 2021

The interaction between Sgt1p and Skp1p is regulated by HSP90 chaperones and is required for proper CBF3 assembly

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7 January 2021

Molecular chaperone Hsp90 associates with resistance protein N and its signaling proteins SGT1 and Rar1 to modulate an innate immune response in plants

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7 January 2021

Inhibitors of the HSP90 molecular chaperone: current status

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7 January 2021

17-AAG, an Hsp90 inhibitor, causes kinetochore defects: a novel mechanism by which 17-AAG inhibits cell proliferation

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NALP3 forms an IL-1beta-processing inflammasome with increased activity in Muckle-Wells autoinflammatory disorder

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Identification of CARDIAK, a RIP-like kinase that associates with caspase-1

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7 January 2021

Identifiers

DOI

10.1038/NI1459

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3 November 2017

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