(Q42641339)

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Development of a whole body physiologically based model to characterise the pharmacokinetics of benzodiazepines. 1: Estimation of rat tissue-plasma partition ratios

scientific article published on August 2004

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Europe PubMed Central

PubMed publication ID

4 November 2017

Development of a whole body physiologically based model to characterise the pharmacokinetics of benzodiazepines. 1: Estimation of rat tissue-plasma partition ratios (English)

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Europe PubMed Central

PubMed publication ID

4 November 2017

pharmacokinetics

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author name string

Ivelina Gueorguieva

1

1 reference

Europe PubMed Central

PubMed publication ID

4 November 2017

Ivan A Nestorov

2

1 reference

Europe PubMed Central

PubMed publication ID

4 November 2017

Susan Murby

3

1 reference

Europe PubMed Central

PubMed publication ID

4 November 2017

Sophie Gisbert

4

1 reference

Europe PubMed Central

PubMed publication ID

4 November 2017

Brent Collins

5

1 reference

Europe PubMed Central

PubMed publication ID

4 November 2017

Kelly Dickens

6

1 reference

Europe PubMed Central

PubMed publication ID

4 November 2017

Judith Duffy

7

1 reference

Europe PubMed Central

PubMed publication ID

4 November 2017

Ziad Hussain

8

1 reference

Europe PubMed Central

PubMed publication ID

4 November 2017

Malcolm Rowland

9

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Europe PubMed Central

PubMed publication ID

4 November 2017

publication date

1 August 2004

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Europe PubMed Central

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4 November 2017

Journal of Pharmacokinetics and Pharmacodynamics

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Europe PubMed Central

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4 November 2017

31

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Europe PubMed Central

PubMed publication ID

4 November 2017

4

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Europe PubMed Central

PubMed publication ID

4 November 2017

269-298

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Europe PubMed Central

PubMed publication ID

4 November 2017

Validation of assay methodology used in pharmacokinetic studies

1 reference

https://pubmed.ncbi.nlm.nih.gov/15563004

12 December 2020

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Characterization of six in vitro reactions mediated by human cytochrome P450: application to the testing of cytochrome P450-directed antibodies

1 reference

https://pubmed.ncbi.nlm.nih.gov/15563004

12 December 2020

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Physiologically based pharmacokinetics and the risk assessment process for methylene chloride.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15563004

12 December 2020

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Regional blood flow in conscious resting rats determined by microsphere distribution

1 reference

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12 December 2020

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Differential reinforcement of low rate performance, pharmacokinetics and pharmacokinetic-pharmacodynamic modeling: independent interaction of alprazolam and caffeine.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15563004

12 December 2020

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Precision and sensitivity of pharmacokinetic models for cancer risk assessment: tetrachloroethylene in mice, rats, and humans

1 reference

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12 December 2020

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Quantitative structure-pharmacokinetics relationships: I. Development of a whole-body physiologically based model to characterize changes in pharmacokinetics across a homologous series of barbiturates in the rat.

1 reference

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12 December 2020

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Pharmacokinetics of diazepam in the rat: influence of a carbon tetrachloride-induced hepatic injury

1 reference

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Pharmacokinetic-pharmacodynamic modeling of stimulatory and sedative effects of alprazolam: timing performance deficits.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15563004

12 December 2020

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In vitro and in vivo assessment of hepatic and extrahepatic metabolism of diazepam in the rat.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15563004

12 December 2020

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In-vivo and in-vitro metabolic clearance of midazolam, a cytochrome P450 3A substrate, by the liver under normal and increased enzyme activity in rats.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15563004

12 December 2020

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Prediction of in vivo tissue distribution from in vitro data. 3. Correlation between in vitro and in vivo tissue distribution of a homologous series of nine 5-n-alkyl-5-ethyl barbituric acids

1 reference

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12 December 2020

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Pharmacokinetic/pharmacodynamic relationship of benzodiazepines in the direct cortical stimulation model of anticonvulsant effect

1 reference

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12 December 2020

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Anticonvulsant pharmacodynamics and disposition of triazolam in rats

1 reference

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12 December 2020

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Species difference in diazepam metabolism and anticonvulsant effect

1 reference

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Physiologic modeling of cyclosporin kinetics in rat and man.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15563004

12 December 2020

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Prediction of diazepam disposition in the rat and man by a physiologically based pharmacokinetic model

1 reference

https://pubmed.ncbi.nlm.nih.gov/15563004

12 December 2020

based on heuristic

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Rate of change of blood concentrations is a major determinant of the pharmacodynamics of midazolam in rats.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15563004

12 December 2020

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Developing and testing integrated multicompartment models to describe a single-input multiple-output study using the SAAM II software system

1 reference

https://pubmed.ncbi.nlm.nih.gov/15563004

12 December 2020

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Prediction of pharmacokinetics prior to in vivo studies. 1. Mechanism-based prediction of volume of distribution.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15563004

12 December 2020

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Kinetics of distribution and adipose tissue storage as a function of lipophilicity and chemical structure. II. Benzodiazepines

1 reference

https://pubmed.ncbi.nlm.nih.gov/15563004

12 December 2020

based on heuristic

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Pharmacokinetics and plasma binding of diazepam in man, dog, rabbit, guinea pig and rat

1 reference

https://pubmed.ncbi.nlm.nih.gov/15563004

12 December 2020

based on heuristic

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Effect of age, body composition, and lipid solubility on benzodiazepine tissue distribution in rats.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15563004

12 December 2020

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Comparative physiological pharmacokinetics of fentanyl and alfentanil in rats and humans based on parametric single-tissue models.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15563004

12 December 2020

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A population analysis of the pharmacokinetics and pharmacodynamics of midazolam in the rat.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15563004

12 December 2020

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Pharmacokinetic-pharmacodynamic modelling of the EEG effects of midazolam in individual rats: influence of rate and route of administration

1 reference

https://pubmed.ncbi.nlm.nih.gov/15563004

12 December 2020

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Multiple imputation: a primer

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12 December 2020

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Hepatic clearance of drugs. I. Theoretical considerations of a "well-stirred" model and a "parallel tube" model. Influence of hepatic blood flow, plasma and blood cell binding, and the hepatocellular enzymatic activity on hepatic drug clearance

1 reference

https://pubmed.ncbi.nlm.nih.gov/15563004

12 December 2020

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Physiologically based pharmacokinetic study on a cyclosporin derivative, SDZ IMM 125

1 reference

https://pubmed.ncbi.nlm.nih.gov/15563004

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Estimation of tissue-to-plasma partition coefficients used in physiological pharmacokinetic models

1 reference

https://pubmed.ncbi.nlm.nih.gov/15563004

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Area method for the estimation of partition coefficients for physiological pharmacokinetic models

1 reference

https://pubmed.ncbi.nlm.nih.gov/15563004

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Kinetics of diazepam metabolism in rat hepatic microsomes and hepatocytes and their use in predicting in vivo hepatic clearance.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15563004

12 December 2020

based on heuristic

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Man versus beast: pharmacokinetic scaling in mammals

1 reference

https://pubmed.ncbi.nlm.nih.gov/15563004

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Further studies on species difference in diazepam metabolism

1 reference

https://pubmed.ncbi.nlm.nih.gov/15563004

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Determination of the steady state tissue distribution of midazolam in the rat.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15563004

12 December 2020

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Pharmacokinetics of flunitrazepam in rats studied by a radioreceptor assay

1 reference

https://pubmed.ncbi.nlm.nih.gov/15563004

12 December 2020

based on heuristic

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The effect of three H2-receptor antagonists on the disposition of midazolam in the rat in-situ perfused liver model.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15563004

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Physiologically Based Pharmacokinetic Modeling: Principles and Applications

1 reference

https://pubmed.ncbi.nlm.nih.gov/15563004

12 December 2020

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Metabolism and distribution of 1-[14C]alprazolam in rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/15563004

12 December 2020

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Pharmacokinetic-EEG effect relationship of midazolam in aging BN/BiRij rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/15563004

12 December 2020

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From piecewise to full physiologic pharmacokinetic modeling: applied to thiopental disposition in the rat.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15563004

12 December 2020

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Pharmacokinetic-pharmacodynamic modeling of the coexistence of stimulatory and sedative components for midazolam.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15563004

12 December 2020

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Pharmacological activities of clobazam and diazepam in the rat: relation to drug brain levels

1 reference

https://pubmed.ncbi.nlm.nih.gov/15563004

12 December 2020

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A double-peak phenomenon in the pharmacokinetics of alprazolam after oral administration.

1 reference

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12 December 2020

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Adaptive changes in the pharmacodynamics of midazolam in different experimental models of epilepsy: kindling, cortical stimulation and genetic absence epilepsy.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15563004

12 December 2020

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Pharmacokinetic-pharmacodynamic modeling of the electroencephalographic effects of benzodiazepines. Correlation with receptor binding and anticonvulsant activity

1 reference

https://pubmed.ncbi.nlm.nih.gov/15563004

12 December 2020

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Physiologically based pharmacokinetics of cyclosporine A: reevaluation of dose-nonlinear kinetics in rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/15563004

12 December 2020

based on heuristic

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Fluid Shifts and Other Factors Affecting Plasma Protein Binding of Prednisolone by Equilibrium Dialysis

1 reference

https://pubmed.ncbi.nlm.nih.gov/15563004

12 December 2020

based on heuristic

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Tissue distribution of fentanyl and alfentanil in the rat cannot be described by a blood flow limited model

1 reference

https://pubmed.ncbi.nlm.nih.gov/15563004

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tissue distribution of 14C-diazepam and its metabolites in rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/15563004

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1023/B:JOPA.0000042737.14033.C6

1 reference

Europe PubMed Central

PubMed publication ID

4 November 2017

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PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

4 November 2017

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