(Q42703925)

5 November 2017

title

Combining an amyloid-beta (Aβ) cleaving enzyme inhibitor with a γ-secretase modulator results in an additive reduction of Aβ production (English)

1 reference

5 November 2017

Per I Arvidsson

9

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author name string

Kia Strömberg

1

1 reference

5 November 2017

Susanna Eketjäll

2

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5 November 2017

Biljana Georgievska

3

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5 November 2017

Karin Tunblad

4

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5 November 2017

Kristina Eliason

5

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5 November 2017

Fredrik Olsson

6

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5 November 2017

Ann-Cathrin Radesäter

7

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5 November 2017

Rebecka Klintenberg

8

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5 November 2017

Stefan von Berg

10

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5 November 2017

Johanna Fälting

11

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5 November 2017

Richard F Cowburn

12

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5 November 2017

Michael Dabrowski

13

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5 November 2017

language of work or name

English

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publication date

7 November 2014

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5 November 2017

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5 November 2017

volume

282

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5 November 2017

issue

1

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5 November 2017

page(s)

65-73

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13103

5 November 2017

1 reference

Alzheimer's disease: strategies for disease modification

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13103

Amyloid deposition as the central event in the aetiology of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13103

Identification of a Novel Aspartic Protease (Asp 2) as β-Secretase

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13103

Purification and cloning of amyloid precursor protein beta-secretase from human brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13103

Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13103

Membrane-anchored aspartyl protease with Alzheimer's disease beta-secretase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13103

Human aspartic protease memapsin 2 cleaves the beta-secretase site of beta-amyloid precursor protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13103

Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13103

Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13103

APH-1 is a multipass membrane protein essential for the Notch signaling pathway in Caenorhabditis elegans embryos

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13103

Mammalian APH-1 interacts with presenilin and nicastrin and is required for intramembrane proteolysis of amyloid-beta precursor protein and Notch

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13103

PEN-2 is an integral component of the gamma-secretase complex required for coordinated expression of presenilin and nicastrin

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13103

aph-1 and pen-2 are required for Notch pathway signaling, gamma-secretase cleavage of betaAPP, and presenilin protein accumulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13103

γ-Secretase is a membrane protein complex comprised of presenilin, nicastrin, aph-1, and pen-2

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13103

Reconstitution of gamma-secretase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13103

Deciphering the molecular basis of memory failure in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13103

Amyloid-beta protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13103

BACE knockout mice are healthy despite lacking the primary beta-secretase activity in brain: implications for Alzheimer's disease therapeutics

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13103

Control of peripheral nerve myelination by the beta-secretase BACE1

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13103

Bace1 modulates myelination in the central and peripheral nervous system.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13103

Genetic deletion of BACE1 in mice affects remyelination of sciatic nerves

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13103

BACE1 deficiency causes altered neuronal activity and neurodegeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13103

A mutation in APP protects against Alzheimer’s disease and age-related cognitive decline

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13103

gamma-secretases: from cell biology to therapeutic strategies

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13103

Novel research horizons for presenilins and γ-secretases in cell biology and disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13103

Advances in the identification of γ-secretase inhibitors for the treatment of Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13103

Safety profile of semagacestat, a gamma-secretase inhibitor: IDENTITY trial findings

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13103

Targeting the β secretase BACE1 for Alzheimer's disease therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13103

Modulation of notch processing by gamma-secretase inhibitors causes intestinal goblet cell metaplasia and induction of genes known to specify gut secretory lineage differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13103

Notch/gamma-secretase inhibition turns proliferative cells in intestinal crypts and adenomas into goblet cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13103

A subset of NSAIDs lower amyloidogenic Abeta42 independently of cyclooxygenase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13103

First and second generation γ-secretase modulators (GSMs) modulate amyloid-β (Aβ) peptide production through different mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13103

Modeling an anti-amyloid combination therapy for Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13103

Second generation γ-secretase modulators exhibit different modulation of Notch β and Aβ production

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13103

Discovery of AZD3839, a Potent and Selective BACE1 Inhibitor Clinical Candidate for the Treatment of Alzheimer Disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13103

Characterization of intermediate steps in amyloid beta (Aβ) production under near-native conditions

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13103

Generation of Abeta38 and Abeta42 is independently and differentially affected by familial Alzheimer disease-associated presenilin mutations and gamma-secretase modulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13103

21 January 2018

Identifiers

DOI

10.1111/FEBS.13103

1 reference

5 November 2017

1 reference