(Q42717290)

English

Long-term arsenic exposure induces histone H3 Lys9 dimethylation without altering DNA methylation in the promoter region of p16(INK4a) and down-regulates its expression in the liver of mice

scientific article published on 25 June 2012

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scholarly article

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Europe PubMed Central

PubMed publication ID

5 November 2017

Long-term arsenic exposure induces histone H3 Lys9 dimethylation without altering DNA methylation in the promoter region of p16(INK4a) and down-regulates its expression in the liver of mice (English)

1 reference

Europe PubMed Central

PubMed publication ID

5 November 2017

DNA methylation

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author name string

Takehiro Suzuki

1

1 reference

Europe PubMed Central

PubMed publication ID

5 November 2017

Keiko Nohara

2

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Europe PubMed Central

PubMed publication ID

5 November 2017

language of work or name

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publication date

25 June 2012

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5 November 2017

Journal of Applied Toxicology

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Europe PubMed Central

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5 November 2017

33

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Europe PubMed Central

PubMed publication ID

5 November 2017

9

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Europe PubMed Central

PubMed publication ID

5 November 2017

951-958

1 reference

Europe PubMed Central

PubMed publication ID

5 November 2017

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1 reference

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Coordinated recruitment of histone methyltransferase G9a and other chromatin-modifying enzymes in SHP-mediated regulation of hepatic bile acid metabolism

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Regulation of the INK4b-ARF-INK4a tumour suppressor locus: all for one or one for all.

1 reference

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Arsenic exposure and toxicology: a historical perspective

1 reference

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The oncogene and Polycomb-group gene bmi-1 regulates cell proliferation and senescence through the ink4a locus

1 reference

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Epigenetic mediated transcriptional activation of WNT5A participates in arsenical-associated malignant transformation

1 reference

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Chromatin modifications and their function

1 reference

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Cytokeratin 8/18 as a new marker of mouse liver preneoplastic lesions

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Regulation of tissue-specific expression of the human and mouse urate transporter 1 gene by hepatocyte nuclear factor 1 alpha/beta and DNA methylation

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UHRF1 binds G9a and participates in p21 transcriptional regulation in mammalian cells

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Alterations of DNA methylation and histone modifications contribute to gene silencing in hepatocellular carcinomas.

1 reference

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pRB family proteins are required for H3K27 trimethylation and Polycomb repression complexes binding to and silencing p16INK4alpha tumor suppressor gene.

1 reference

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Liver is a target of arsenic carcinogenesis

1 reference

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5′ CpG island methylation is associated with transcriptional silencing of the tumour suppressor p16/CDKN2/MTS1 in human cancers

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Comparison of the 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-induced CYP1A1 gene expression profile in lymphocytes from mice, rats, and humans: most potent induction in humans.

1 reference

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Global DNA methylation in the mouse liver is affected by methyl deficiency and arsenic in a sex-dependent manner

1 reference

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Sodium arsenite administration via drinking water increases genome-wide and Ha-ras DNA hypomethylation in methyl-deficient C57BL/6J mice

1 reference

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Effects of arsenic exposure on DNA methylation and epigenetic gene regulation

1 reference

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An Emerging Role for Epigenetic Dysregulation in Arsenic Toxicity and Carcinogenesis

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Marked increase in bladder and lung cancer mortality in a region of Northern Chile due to arsenic in drinking water

1 reference

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Functional cooperation between HP1 and DNMT1 mediates gene silencing.

1 reference

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The induction of H3K9 methylation by PIWIL4 at the p16Ink4a locus

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Regulatory factors involved in species-specific modulation of arylhydrocarbon receptor (AhR)-dependent gene expression in humans and mice

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Aberrant methylations in cancer cells: where do they come from?

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Mechanisms and functions of Tet protein-mediated 5-methylcytosine oxidation

1 reference

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Histone deacetylase inhibitor depsipeptide activates silenced genes through decreasing both CpG and H3K9 methylation on the promoter.

1 reference

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Chronic health effects in people exposed to arsenic via the drinking water: dose-response relationships in review

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Arsenite alters global histone H3 methylation

1 reference

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21 January 2018

Identifiers

10.1002/JAT.2765

1 reference

Europe PubMed Central

PubMed publication ID

5 November 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

5 November 2017

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