(Q36572080)

15 August 2017

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title

Regulation of the INK4b-ARF-INK4a tumour suppressor locus: all for one or one for all. (English)

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15 August 2017

Jesús Gil

1

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15 August 2017

Gordon Peters

series ordinal

2

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15 August 2017

language of work or name

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1 September 2006

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Nature Reviews Molecular Cell Biology

15 August 2017

published in

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15 August 2017

volume

7

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15 August 2017

issue

9

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15 August 2017

page(s)

667-677

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Oncogenic activity of Cdc6 through repression of the INK4/ARF locus

15 August 2017

cites work

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Stem cells and cancer; the polycomb connection

31 March 2020

1 reference

INK4a/ARF: a multifunctional tumor suppressor locus

31 March 2020

1 reference

A cell cycle regulator potentially involved in genesis of many tumor types

31 March 2020

1 reference

Deletions of the cyclin-dependent kinase-4 inhibitor gene in multiple human cancers

31 March 2020

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p15INK4B is a potential effector of TGF-beta-induced cell cycle arrest

31 March 2020

1 reference

Alternative reading frames of the INK4a tumor suppressor gene encode two unrelated proteins capable of inducing cell cycle arrest

31 March 2020

1 reference

Comparative structure and characterization of a CDKN2 gene in a Xiphophorus fish melanoma model.

31 March 2020

1 reference

One INK4 gene and no ARF at the Fugu equivalent of the human INK4A/ARF/INK4B tumour suppressor locus

31 March 2020

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Absence of p16INK4a and truncation of ARF tumor suppressors in chickens.

31 March 2020

1 reference

Cancer-associated mutations at the INK4a locus cancel cell cycle arrest by p16INK4a but not by the alternative reading frame protein p19ARF.

31 March 2020

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The alternative product from the human CDKN2A locus, p14(ARF), participates in a regulatory feedback loop with p53 and MDM2.

31 March 2020

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Defining the molecular basis of Arf and Hdm2 interactions

31 March 2020

1 reference

Mechanisms of cyclin-dependent kinase regulation: structures of Cdks, their cyclin activators, and Cip and INK4 inhibitors

31 March 2020

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The Arf tumor suppressor gene promotes hyaloid vascular regression during mouse eye development

31 March 2020

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Ink4a/Arf expression is a biomarker of aging

31 March 2020

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Expression of the p16INK4a tumor suppressor versus other INK4 family members during mouse development and aging.

31 March 2020

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Arf tumor suppressor promoter monitors latent oncogenic signals in vivo

31 March 2020

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Upregulation of chicken p15INK4b at senescence and in the developing brain.

31 March 2020

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Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a

31 March 2020

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Historical claims and current interpretations of replicative aging

31 March 2020

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Opinion: Comparative biology of mouse versus human cells: modelling human cancer in mice

31 March 2020

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Tumor suppression at the mouse INK4a locus mediated by the alternative reading frame product p19ARF

31 March 2020

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Limited overlapping roles of P15(INK4b) and P18(INK4c) cell cycle inhibitors in proliferation and tumorigenesis

31 March 2020

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Loss of p16Ink4a confers susceptibility to metastatic melanoma in mice

31 March 2020

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Loss of p16Ink4a with retention of p19Arf predisposes mice to tumorigenesis

31 March 2020

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The differential impact of p16(INK4a) or p19(ARF) deficiency on cell growth and tumorigenesis.

31 March 2020

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Differential effects of p19(Arf) and p16(Ink4a) loss on senescence of murine bone marrow-derived preB cells and macrophages

31 March 2020

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Premature senescence involving p53 and p16 is activated in response to constitutive MEK/MAPK mitogenic signaling

31 March 2020

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Senescence of human fibroblasts induced by oncogenic Raf.

31 March 2020

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Opposing effects of Ets and Id proteins on p16INK4a expression during cellular senescence

31 March 2020

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BRAFE600-associated senescence-like cell cycle arrest of human naevi

31 March 2020

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Mitogen-activated protein kinase p38 defines the common senescence-signalling pathway

31 March 2020

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High Intensity ras Signaling Induces Premature Senescence by Activating p38 Pathway in Primary Human Fibroblasts

31 March 2020

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Sequential activation of the MEK-extracellular signal-regulated kinase and MKK3/6-p38 mitogen-activated protein kinase pathways mediates oncogenic ras-induced premature senescence

31 March 2020

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Inactivation of the Wip1 phosphatase inhibits mammary tumorigenesis through p38 MAPK-mediated activation of the p16(Ink4a)-p19(Arf) pathway

31 March 2020

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Reactive oxygen species act through p38 MAPK to limit the lifespan of hematopoietic stem cells

31 March 2020

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Tumour biology: senescence in premalignant tumours

31 March 2020

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Cellular response to oncogenic ras involves induction of the Cdk4 and Cdk6 inhibitor p15(INK4b)

31 March 2020

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p19ARF links the tumour suppressor p53 to Ras

31 March 2020

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Oncogenic ras activates the ARF-p53 pathway to suppress epithelial cell transformation

31 March 2020

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Role of p14(ARF) in replicative and induced senescence of human fibroblasts

31 March 2020

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INK4a-deficient human diploid fibroblasts are resistant to RAS-induced senescence

31 March 2020

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E2F and Ras Synergize in Transcriptionally Activating p14ARFExpression

31 March 2020

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Species- and cell type-specific requirements for cellular transformation

31 March 2020

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Induction of ARF tumor suppressor gene expression and cell cycle arrest by transcription factor DMP1.

31 March 2020

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Ras-Raf-Arf signaling critically depends on the Dmp1 transcription factor

31 March 2020

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Induction of apoptosis in fibroblasts by c-myc protein

31 March 2020

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Cyclin E and c-Myc promote cell proliferation in the presence of p16INK4a and of hypophosphorylated retinoblastoma family proteins.

31 March 2020

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Overexpression of MYC causes p53-dependent G2 arrest of normal fibroblasts

31 March 2020

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Identification of CDK4 as a target of c-MYC.

31 March 2020

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c-Myc regulates cyclin D-Cdk4 and -Cdk6 activity but affects cell cycle progression at multiple independent points

31 March 2020

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c-Myc can induce DNA damage, increase reactive oxygen species, and mitigate p53 function: a mechanism for oncogene-induced genetic instability

31 March 2020

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Tumor suppressor p16INK4a determines sensitivity of human cells to transformation by cooperating cellular oncogenes

31 March 2020

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Reduced c-Myc signaling triggers telomere-independent senescence by regulating Bmi-1 and p16(INK4a).

31 March 2020

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Werner syndrome protein limits MYC-induced cellular senescence

31 March 2020

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Myc signaling via the ARF tumor suppressor regulates p53-dependent apoptosis and immortalization

31 March 2020

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Novel zinc finger gene implicated as myc collaborator by retrovirally accelerated lymphomagenesis in E mu-myc transgenic mice.

31 March 2020

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Identification of cooperating oncogenes in E mu-myc transgenic mice by provirus tagging

31 March 2020

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Disruption of the ARF-Mdm2-p53 tumor suppressor pathway in Myc-induced lymphomagenesis

31 March 2020

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Multiple docking sites on substrate proteins form a modular system that mediates recognition by ERK MAP kinase

31 March 2020

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p19ARF directly and differentially controls the functions of c-Myc independently of p53.

31 March 2020

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Myc-ARF (alternate reading frame) interaction inhibits the functions of Myc.

31 March 2020

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TGFbeta influences Myc, Miz-1 and Smad to control the CDK inhibitor p15INK4b

31 March 2020

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Repression of p15INK4b expression by Myc through association with Miz-1

31 March 2020

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Myc downregulation by transforming growth factor beta required for activation of the p15(Ink4b) G(1) arrest pathway.

31 March 2020

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Regulation of p16CDKN2 expression and its implications for cell immortalization and senescence

31 March 2020

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Accumulation of p16INK4a in mouse fibroblasts as a function of replicative senescence and not of retinoblastoma gene status

31 March 2020

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E1A signaling to p53 involves the p19(ARF) tumor suppressor

31 March 2020

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Suppression of the p53- or pRB-mediated G1 checkpoint is required for E2F-induced S-phase entry

31 March 2020

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Computer-assisted identification of cell cycle-related genes: new targets for E2F transcription factors

31 March 2020

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Repression of the Arf tumor suppressor by E2F3 is required for normal cell cycle kinetics

31 March 2020

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Distinct E2F-mediated transcriptional program regulates p14ARF gene expression

31 March 2020

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Tumor suppression by Ink4a-Arf: progress and puzzles

31 March 2020

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JunB suppresses cell proliferation by transcriptional activation of p16(INK4a) expression

31 March 2020

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AP-1 dimers regulate transcription of the p14/p19ARF tumor suppressor gene.

31 March 2020

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JunD protects cells from p53-dependent senescence and apoptosis.

31 March 2020

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Highly penetrant, rapid tumorigenesis through conditional inversion of the tumor suppressor gene Snf5

31 March 2020

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Re-expression of hSNF5/INI1/BAF47 in pediatric tumor cells leads to G1 arrest associated with induction of p16ink4a and activation of RB.

31 March 2020

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P16INK4a is required for hSNF5 chromatin remodeler-induced cellular senescence in malignant rhabdoid tumor cells

31 March 2020

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Different telomere damage signaling pathways in human and mouse cells

31 March 2020

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Telomere shortening triggers senescence of human cells through a pathway involving ATM, p53, and p21(CIP1), but not p16(INK4a)

31 March 2020

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Significant Role for p16INK4a in p53-Independent Telomere-Directed Senescence

31 March 2020

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Sequential extension of proliferative lifespan in human fibroblasts induced by over-expression of CDK4 or 6 and loss of p53 function.

31 March 2020

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MITF links differentiation with cell cycle arrest in melanocytes by transcriptional activation of INK4A

31 March 2020

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Mitf cooperates with Rb1 and activates p21Cip1 expression to regulate cell cycle progression

31 March 2020

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Inhibition of v-Abl transformation by p53 and p19ARF

31 March 2020

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DAP kinase activates a p19ARF/p53-mediated apoptotic checkpoint to suppress oncogenic transformation

31 March 2020

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Deregulated beta-catenin induces a p53- and ARF-dependent growth arrest and cooperates with Ras in transformation

31 March 2020

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The basic helix-loop-helix transcription factor TAL1/SCL inhibits the expression of the p16INK4A and pTalpha genes

31 March 2020

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LMP1 of Epstein-Barr virus suppresses cellular senescence associated with the inhibition of p16INK4a expression

31 March 2020

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Epstein-Barr virus LMP1 blocks p16INK4a-RB pathway by promoting nuclear export of E2F4/5

31 March 2020

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Id1 regulation of cellular senescence through transcriptional repression of p16/Ink4a.

31 March 2020

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Early growth response 1 protein, an upstream gatekeeper of the p53 tumor suppressor, controls replicative senescence

31 March 2020

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The t(8;21) fusion protein, AML1 ETO, specifically represses the transcription of the p14(ARF) tumor suppressor in acute myeloid leukemia

31 March 2020

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Role of the proto-oncogene Pokemon in cellular transformation and ARF repression

31 March 2020

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Functional and physical interactions of the ARF tumor suppressor with p53 and Mdm2

31 March 2020

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The human ARF cell cycle regulatory gene promoter is a CpG island which can be silenced by DNA methylation and down-regulated by wild-type p53.

31 March 2020

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Senescence bypass screen identifies TBX2, which represses Cdkn2a (p19(ARF)) and is amplified in a subset of human breast cancers.

31 March 2020

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TBX-3, the gene mutated in Ulnar-Mammary Syndrome, is a negative regulator of p19ARF and inhibits senescence

31 March 2020

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The T-box repressors TBX2 and TBX3 specifically regulate the tumor suppressor gene p14ARF via a variant T-site in the initiator

31 March 2020

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Twist is a potential oncogene that inhibits apoptosis

31 March 2020

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Gene repression by Polycomb group protein complexes: a distinct complex for every occasion?

31 March 2020

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Polycomb complexes and silencing mechanisms.

31 March 2020

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The oncogene and Polycomb-group gene bmi-1 regulates cell proliferation and senescence through the ink4a locus

31 March 2020

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Posterior transformation, neurological abnormalities, and severe hematopoietic defects in mice with a targeted deletion of the bmi-1 proto-oncogene

31 March 2020

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Bmi-1 dependence distinguishes neural stem cell self-renewal from progenitor proliferation

31 March 2020

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Bmi-1 determines the proliferative capacity of normal and leukaemic stem cells

31 March 2020

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Bmi-1 is required for maintenance of adult self-renewing haematopoietic stem cells

31 March 2020

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Ink4a and Arf differentially affect cell proliferation and neural stem cell self-renewal in Bmi1-deficient mice

31 March 2020

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Bmi-1 promotes neural stem cell self-renewal and neural development but not mouse growth and survival by repressing the p16Ink4a and p19Arf senescence pathways

31 March 2020

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Disruption of E2F signaling suppresses the INK4a-induced proliferative defect in M33-deficient mice

31 March 2020

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Mammalian polyhomeotic homologues Phc2 and Phc1 act in synergy to mediate polycomb repression of Hox genes

31 March 2020

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Rnf2 (Ring1b) deficiency causes gastrulation arrest and cell cycle inhibition

31 March 2020

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Polycomb CBX7 has a unifying role in cellular lifespan

31 March 2020

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A bivalent chromatin structure marks key developmental genes in embryonic stem cells

31 March 2020

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Polycomb complexes repress developmental regulators in murine embryonic stem cells

31 March 2020

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Genome-wide mapping of Polycomb target genes unravels their roles in cell fate transitions

31 March 2020

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Control of developmental regulators by Polycomb in human embryonic stem cells

31 March 2020

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Chromosomal distribution of PcG proteins during Drosophila development

31 March 2020

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Genome-wide profiling of PRC1 and PRC2 Polycomb chromatin binding in Drosophila melanogaster

31 March 2020

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Control of the replicative life span of human fibroblasts by p16 and the polycomb protein Bmi-1

31 March 2020

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Bmi1 is essential for cerebellar development and is overexpressed in human medulloblastomas

31 March 2020

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Transcriptional coactivator Cited2 induces Bmi1 and Mel18 and controls fibroblast proliferation via Ink4a/ARF

31 March 2020

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Growth retardation and premature aging phenotypes in mice with disruption of the SNF2-like gene, PASG

31 March 2020

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Bmi-1 Regulation of INK4A-ARF Is a Downstream Requirement for Transformation of Hematopoietic Progenitors by E2a-Pbx1

31 March 2020

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P66(ShcA) interacts with MAPKAP kinase 2 and regulates its activity

31 March 2020

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MAPKAP kinase 3pK phosphorylates and regulates chromatin association of the polycomb group protein Bmi1

31 March 2020

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Signaling to chromatin through histone modifications

31 March 2020

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Regulation of HP1-chromatin binding by histone H3 methylation and phosphorylation

31 March 2020

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Histone H3 serine 10 phosphorylation by Aurora B causes HP1 dissociation from heterochromatin

31 March 2020

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Binary switches and modification cassettes in histone biology and beyond.

31 March 2020

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Contribution of p16(INK4a) to replicative senescence of human fibroblasts

31 March 2020

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Association of BMI1 with polycomb bodies is dynamic and requires PRC2/EZH2 and the maintenance DNA methyltransferase DNMT1

31 March 2020

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The Polycomb group protein EZH2 directly controls DNA methylation

31 March 2020

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The complexity of p53 modulation: emerging patterns from divergent signals

31 March 2020

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The p53-Mdm2 module and the ubiquitin system.

31 March 2020

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Proliferation, cell cycle and apoptosis in cancer

31 March 2020

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Senescent cells, tumor suppression, and organismal aging: good citizens, bad neighbors

31 March 2020

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The power and the promise of oncogene-induced senescence markers.

31 March 2020

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31 March 2020

Identifiers

DOI

10.1038/NRM1987

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Dimensions Publication ID

15 August 2017

1009107865

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